Computed Tomography Screening for Lung Cancer

Roth, Joshua A.; Ramsey, Scott D.

doi:10.1001/jama.2015.17877

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…However, SqCC is often diagnosed at an advanced stage, by which point approximately two-thirds of all patients have metastatic tumors when diagnosed. Currently the low-dose computed tomography (LDCT) scan approach is used to as a non-invasive method for detecting tumors at early stages; however, this method has yielded conflicting results ( 6 , 7 ). Therefore, it is necessary to develop novel, minimally invasive methods, such as molecular biomarkers, for the early detection of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Global lipidomics reveals two plasma lipids as novel biomarkers for the detection of squamous cell lung cancer: A pilot study

Chen

Zhu

et al. 2018

Oncol Lett

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Lipids are known to serve important roles in energy storage, membrane structure and signal transduction as well as in human cancers. In the present study, lipidomics was employed in order to identify plasma lipid markers for the early detection of lung cancer. Mass spectrometry was performed to profile 390 individual lipids in 44 plasma samples obtained from a training discovery cohort, which included 22 patients with squamous cell lung carcinoma (SqCC) and 22 high-risk individuals. An additional cohort that included 22 high-risk individuals and 22 patients with SqCC was further used for validation. During the training stage, a total of 20 distinct lipids that were significantly distributed between the high-risk and SqCC cases, were identified. A panel of 2 lipid markers (C18:2 cholesterol esters and sphingomyelin 22:0) were then further defined using the training accuracy values of 95.5% sensitivity, 90.9% specificity and 95.2% area under the receiver operating characteristic curve (AUC). The validation accuracy values applied for the additional cohort were 93.9% sensitivity, 92.9% specificity and 98.7% AUC. Thus, in the present study, 2 lipid markers that were able to discern SqCC patients from high-risk individuals with a high sensitivity, specificity and accuracy, were identified. These results may provide vital information for the development of a quick and safe blood test for the early diagnosis of SqCC.

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Section: Introductionmentioning

confidence: 99%