Computed tomography of the chest in small cell lung cancer: potential new prognostic signs

Whitley, NO; Jz, Fuks; McCrea, ES; Whitacre, Margaret; Masler, JA; Je, Whitley; Aisner, Joseph

doi:10.2214/ajr.142.5.885

Cited by 21 publications

(5 citation statements)

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“…Pleural effusion was noted in 3870, pericardial thickening in 38%, and tracheobronchial compression in 68%. These figures are remarkably similar to those in Whitley's study [56] of 33 patients in which the corresponding percentages were 40%, 37%, and 73%.…”

Section: Evaluation Of Nodal Metastasissupporting

confidence: 88%

Diagnostic imaging and staging of primary lung cancer

Rubin

Sanders

Harvey

et al. 1993

Seminars in Surgical Oncology

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Improved diagnostic imaging has the potential to guide the surgeon in choice of invasive procedures required for staging and treatment of lung cancer. In the evaluation of a solitary pulmonary nodule, absence of growth for 2 years or certain typical calcifications are strong evidence of benignity, but we do not advocate following indeterminate nodules without a diagnosis because even small nodules may be carcinomas. In assessing chest wall invasion, computed tomography has no greater predictive value than a history of localized pain. The absence of nodes greater than 1.0 cm in short axis diameter on computed tomograms of the thorax is associated with low risk of tumor in mediastinal nodes, but tissue diagnosis is required for certainty. The finding of nodes larger than 1.0 cm may be useful in guiding the surgeon during staging procedures. Currently, there is no advantage of magnetic resonance imaging over computed tomography in evaluation of mediastinal nodes. Complete history and physical examination with routine serum chemistries will identify patients at high risk for metastases and will guide selection of appropriate special studies. It is emphasized that accurate staging requires histologic diagnosis and that CT and thorough surgical evaluation of the mediastinum are complementary procedures in staging of lung cancer.

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Section: Evaluation Of Nodal Metastasissupporting

confidence: 88%

Diagnostic imaging and staging of primary lung cancer

Rubin

Sanders

Harvey

et al. 1993

Seminars in Surgical Oncology

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“…[6–10] Hashimoto et al [9] reviewed 38 patients with SCLC and detected bulky central masses as major CT findings, and most patients with central tumors showed bronchial narrowing. Kazawa et al [10] classified 68 cases of SCLC into 8 types and reported common and rare types.…”

Section: Discussionmentioning

confidence: 99%

“…[12] The endobronchial extension that is common in squamous cell carcinoma is seen less frequently, so the airway obstruction is usually caused by compression by the expanding tumor rather than by intraluminal obstruction. [12] Previous studies [6,7,9,10,15] reported that bronchial narrowing and wall thickening result from tumor spread into the submucosa of affected bronchi, mainly in the ipsilateral hilar bronchus. In the present study, airway involvement was very frequently observed (n = 120, 84.5%) and 2 or more bronchi were more affected than a single bronchus (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…However, only a few studies have reported CT findings of SCLC. [6–10] Pearlberg et al [7] reported distribution of lymph node enlargement and frequency of other intrathoracic findings in 37 patients with SCLC, and Hashimoto et al [9] reported the CT findings of parenchymal lesions such as central or peripheral tumor, obstructive pneumonia, major atelectasis, and tumor extension in 38 patients with SCLC. Furthermore, Kazawa et al [10] classified 68 cases of SCLC into 8 types and reported several features of SCLC.…”

Section: Introductionmentioning

confidence: 99%

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CT findings of small cell lung carcinoma

et al. 2016

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The purpose of this study was to clarify the recognizable computed tomography (CT) features of small cell lung carcinoma (SCLC).Contrast enhanced CT scans were reviewed retrospectively for mass location, mediastinal extension, and other concomitant findings in 142 patients with pathologically proven SCLC. SCLC was classified into hilar mass only (type I), hilar mass with ipsilateral mediastinal extension (type II), hilar mass with bilateral mediastinal extension (type III), and peripheral mass (type IV). When mediastinal lymphadenopathy (m-LAP) was indistinguishable from a hilar mass, we defined it as a mediastinal conglomerate mass (m-CM). Type IIa or IIIa had ipsilateral or bilateral m-LAP and type IIb, IIIb or IIIc had ipsilateral or bilateral m-CM.Type I (n = 8, 5.6%), type II (n = 58, 40.8%), type III (n = 55, 38.8%), and type IV (n = 21, 14.8%) were manifested. The combination of a hilar mass and m-CM was found in 68 patients (47.9%). Type IV masses showed lobulation in 11, microlobulation in 4, both lobulated and irregular margins in 4, and spiculation in 2. A total of 120 patients (84.5%) had a bronchial stenosis/obstruction; single (n = 52) and 2 or more (n = 68). Ninety-five patients (67.0%) had vascular invasion including main/lobar pulmonary artery and superior vena cava, and 55 (38.7%) had pleural effusion and/or pleural nodules. Concomitant parenchymal findings (n = 92, 64.8%) were noted: contiguous consolidation/nodule (n = 45), hematogeneous spread (n = 32), lymphangitic spread (n = 21), obstructive pneumonia (n = 22), and obstructive atelectasis (n = 14).In conclusion, the recognizable CT features of SCLC were a hilar mass with m-CM. Most of the hilar masses showed 2 or more bronchial stenoses/obstructions. Most cases of peripheral SCLC manifested as a lobulated mass rather than a spiculated mass. Vascular invasion and concomitant parenchymal findings were observed commonly.

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“…The tumours were centrally located and mediastinal extension was seen with encasement of mediastinal structures and tracheobronchial compression in 60% of cases. 17,18 The less commonly described peripheral small cell carcinoma is often associated with hilar adenopathy and atelectasis secondary to main stem bronchus compression. 19…”

Section: Image 3a Small Cell Carcinoma Presenting As Hilar Massmentioning

confidence: 99%

Multidetector Row Computed Tomography(MDCT) Evaluation of Bronchogenic Carcinoma and Histopathological Correlation

Narayanaswamy¹

2015

IJMI

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Bronchogenic carcinoma is one among the leading causes of death in males in India and globally. Multidetector row Computed Tomography is a non-invasive technique for evaluation of bronchogenic carcinoma. Aims and objections: To document imaging characteristics of various histopathological cell types of bronchogenic carcinoma by MDCT and to correlate with histopathology. A prospective study was done on 60 patients with clinical or radiological suspicion of bronchogenic carcinoma undergoing MDCT. The final diagnosis was established by histopathology. Study duration was for 2 years from January 2013 to December 2014. Results: MDCT is a promising tool in evaluation of bronchogenic carcinoma. Squamous cell carcinoma is the most common histological celltype, closely followed by adenocarcinoma. Hilar mass was the predominant presentation followed by lung mass.

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Computed tomography of the chest in small cell lung cancer: potential new prognostic signs

Cited by 21 publications

References 0 publications

Diagnostic imaging and staging of primary lung cancer

Diagnostic imaging and staging of primary lung cancer

CT findings of small cell lung carcinoma

Multidetector Row Computed Tomography(MDCT) Evaluation of Bronchogenic Carcinoma and Histopathological Correlation

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