Computed tomography of renal cell carcinoma in patients with terminal renal impairment

Ferda, Jiří; Hora, Milan; Hes, Ondřej; Reischig, Tomáš; Kreuzberg, Boris; Mírka, Hynek; Ferdová, Eva; Ohlidalova, K; Baxa, Jan; Ürge, Tomáš

doi:10.1016/j.ejrad.2007.01.027

Cited by 12 publications

(11 citation statements)

References 20 publications

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“…RCC presents with a frequency that is three to six times higher in patients with end-stage renal disease compared with the general population and the percentage is even higher for pRCC [20,21]. The contrast material used for CECT has a limitation of nephrotoxicity, especially for patients with CKD.…”

Section: Discussionmentioning

confidence: 98%

Papillary renal cell carcinoma and clear cell renal cell carcinoma: Differentiation of distinct histological types with contrast – enhanced ultrasonography

Xue

Lü

Huang

et al. 2015

European Journal of Radiology

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Section: Discussionmentioning

confidence: 98%

Papillary renal cell carcinoma and clear cell renal cell carcinoma: Differentiation of distinct histological types with contrast – enhanced ultrasonography

Xue

Lü

Huang

et al. 2015

European Journal of Radiology

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“…The main risk factor for RCC in renal transplant recipients is ACKD [2], which is present in 70–90% of the patients [3,4]. The diagnosis of ACKD is established via US, CT or MRI [16]. Cysts in ACKD are usually <0.5 cm in diameter but can be up to 2–3 cm.…”

Section: Discussionmentioning

confidence: 99%

Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients

Klatte¹,

Seitz

Waldert³

et al. 2010

BJU International

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Study Type – Therapy (case series) Level of Evidence 4 OBJECTIVE To outline the features and outcomes of renal cell carcinoma (RCC) in native kidneys of renal transplant recipients, who are at increased risk of developing this disease. PATIENTS AND METHODS We retrospectively studied the clinicopathological features and survival of 28 surgically treated RCCs, which developed in 24 renal transplant recipients. Features and outcomes were compared with 671 patients with RCC who had no renal transplant. RESULTS The median interval between renal transplantation and the occurrence of RCC was 5.6 years. Acquired cystic kidney disease was present in 83% of the transplanted patients. Compared with the patients with RCC and no renal transplant, RCCs of native kidneys in transplant recipients were more frequently incidental findings (92% vs 77%, P = 0.092), multifocal (39% vs 15%, P < 0.001), bilateral (17% vs 4%, P = 0.006), had lower T stages (P = 0.040), were smaller (P = 0.027), of lower grades (P = 0.010), were more frequently papillary (43% vs 19%, P = 0.019) and occurred at a significantly younger age (P = 0.022). After a median follow‐up of 6.7 years, eight renal transplant recipients had died (33%), but only two deaths were due to RCC. Survival with metastatic RCC was only 4 months, if a full resection of all metastatic sites was not achieved. In multivariate analysis the presence of a renal transplant had no effect on survival. CONCLUSIONS Most RCCs in renal transplant recipients are incidental low‐stage, low‐grade tumours with a favourable prognosis. The outstanding pathological findings are bilateral occurrence, papillary subtype and multifocality. Prognosis of metastatic RCC is poor but might be favourable if all metastases are resected. Screening for early detection of asymptomatic RCC is advocated.

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“…Other studies indicate that the stimulus for neoplastic growth comes with a cystic transformation of the kidneys. A very strong association with ACKD and an increased incidence of papillary renal tumours have been observed in many studies [ 9 ]. More than 80 % of all patients with end-stage renal disease developing a renal tumour actually have underlying ACKD [ 8 ].…”

Section: Renal Abnormalities In Long-term Haemodialysismentioning

confidence: 97%

“…The leading sign of the tumour is the space occupied by the lesion localised in the atrophic renal parenchyma; the size of the distinguishable tumour is about 5 mm in diameter when causing the bulging of the renal surface [ 9 ]. Smaller lesions under the kidney surface may remain undetected, especially when ultrasound or plain CT is used [ 19 ].…”

Section: Renal Abnormalities In Long-term Haemodialysismentioning

confidence: 99%

Imaging of haemodialysis: renal and extrarenal findings

et al. 2015

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Electrolyte alterations and extra-renal disorders are quite frequent in patients undergoing haemodialysis or peritoneal dialysis. The native kidneys may be the site of important pathologies in patients undergoing dialysis, especially in the form of acquired renal cystic disease with frequent malignant transformation. Renal neoplasms represents an important complication of haemodialysis-associated acquired cystic kidney disease and imaging surveillance is suggested. Extra-renal complications include renal osteodistrophy, brown tumours, and thoracic and cardiovascular complications. Other important fields in which imaging techniques may provide important informations are arteriovenous fistula and graft complications.Teaching points• Renal neoplasms represent a dreaded complication of haemodialysis.• In renal osteodystrophy bone resorption typically manifests along the middle phalanges.• Brown tumours are well-defined lytic lesions radiographically, possibly causing bone expansion.• Vascular calcifications are very common in patients undergoing haemodialysis.• Principal complications of the AV fistula consist of thrombosis, aneurysms and pseudoaneurysms.

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Computed tomography of renal cell carcinoma in patients with terminal renal impairment

Cited by 12 publications

References 20 publications

Papillary renal cell carcinoma and clear cell renal cell carcinoma: Differentiation of distinct histological types with contrast – enhanced ultrasonography

Papillary renal cell carcinoma and clear cell renal cell carcinoma: Differentiation of distinct histological types with contrast – enhanced ultrasonography

Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients

Imaging of haemodialysis: renal and extrarenal findings

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