Computed tomography of pulmonary metastases from osteosarcoma: The less poor technique. A study of 51 patients with histological correlation

Picci, Piero; Vanel, D.; Briccoli, A; Talle, K; Haakenaasen, U.; Malaguti, Cristina; Monti, Carlo; Ferrari, C.; Bacci, Gaetano; Sæter, Gunnar; Alvegård, Thor

doi:10.1023/a:1013103511633

Cited by 91 publications

(64 citation statements)

References 14 publications

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“…The determination or presumption of pulmonary metastases is usually made based on the clinical details, including the radiographic findings, growth characteristics, presence of extrapulmonary metastases, and histological confirmation. However, there are no management guidelines for small pulmonary nodules detected on CT [5][6][7], when the nodules are too small to either biopsy or excise. The purpose of this study was to establish management guidelines for such small nodules in the sarcoma patients.…”

Section: Introductionmentioning

confidence: 99%

Management of small pulmonary nodules in patients with sarcoma

Nakamura

Matsumine

Niimi

et al. 2009

Clin Exp Metastasis

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Small pulmonary nodules in patients with sarcoma are problematic, because it is difficult to distinguish such small metastatic nodules from benign. The purpose of this study was to establish management guidelines for such small pulmonary nodules in patients with sarcoma. Pulmonary nodules were detected in 70 of 206 patients with sarcoma. About 55 patients were classified as having pulmonary metastasis. Seventeen of these 55 patients with pulmonary metastases were excluded from the imaging review because they did not undergo the required imaging examination. This study reviewed 38 patients with metastatic nodules and 15 patients with benign nodules. A statistically significant relationship was observed between the size of the nodules and final clinical decision. The patients with pulmonary nodules which did not exceed 5 mm in size showed significantly better cumulative overall survival rate after the detection of pulmonary nodules than those with larger nodules (5-years: 58.4 vs. 20.4%). There was no significant difference in the overall survival rate between the patients with smaller pulmonary benign lesions which did not exceed 5 mm in size and those with a normal chest CT (5-years: 92.3 vs. 85.3%). The only factor to diagnose in a metastatic pulmonary lesion is the size of the nodules. If the nodule remains < or = 5 mm in size for more than 6 months, the nodule will be a benign lesion. On the contrary, if the nodule becomes larger than 5 mm within 6 months, a surgical excision of the nodules is recommended.

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Section: Introductionmentioning

confidence: 99%

Management of small pulmonary nodules in patients with sarcoma

Nakamura

Matsumine

Niimi

et al. 2009

Clin Exp Metastasis

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“…In addition, the specificity of CT in evaluating the nature of a pulmonary nodule, especially when small, is still limited, and only biopsy or nodule excision are able to reveal the benign or malignant nature of the nodule through histological examination whereas evolution of the radiological finding can only guide the diagnosis between benign or malignant nodular opacities [26].…”

Section: Discussionmentioning

confidence: 99%

“…mento che possono essere normali o non specifici [22] come pure l'aspetto radiologico di noduli polmonari a differente eziologia. Inoltre la specificità della TC, nella valutazione di natura, benigna o maligna, di un nodulo polmonare, specialmente se questo è di piccole dimensioni, è ancora limitata e solo la biopsia o l'asportazione del nodulo sono in grado di rivelare la vera natura della lesione permettendone l'esame istologico, mentre l'evoluzione del reperto radiologico può unicamente orientare la diagnosi tra opacità nodulare benigna o maligna [26].…”

Section: Discussionunclassified

Pulmonary nodules in osteosarcoma patients: differential diagnosis of central venous catheter–related infections in the lungs

et al. 2006

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“…Lung nodules discovered on CT are biopsied or resected. Solitary nodules represent pseudometastasis in about 25% of cases [46]. Pseudo-metastases should always be confirmed in patients with OS.…”

Section: Computed Tomographymentioning

confidence: 96%