Pulmonary nodules in osteosarcoma patients: differential diagnosis of central venous catheter–related infections in the lungs

Longhi, Alessandra; Rimondi, Eugenio; Loro, Loretta; Tetta, Cecilia; Rossi, Giuseppe; DeBenedittis, M.; Bacci, Gaetano

doi:10.1007/s11547-006-0020-9

Cited by 2 publications

(2 citation statements)

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“…In the multivariate analysis, only bone surgery was a risk factor for the occurrence bacterial complications 24. Longhi et al25 found that among patients with OSA, infection of the central catheter with fever were found in 5.6% of them. Authors suggest that the most common complications of the use of central venous catheters were infection and venous thrombosis whereas pulmonary septic emboli were rare 25.…”

Section: Discussionmentioning

confidence: 99%

“…Longhi et al25 found that among patients with OSA, infection of the central catheter with fever were found in 5.6% of them. Authors suggest that the most common complications of the use of central venous catheters were infection and venous thrombosis whereas pulmonary septic emboli were rare 25. We observed that only 6% of infections were associated with post-operative wound infection after surgical procedure, while BSI and the UTI were the most frequent type of infection complication.…”

Section: Discussionmentioning

confidence: 99%

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<p>Infectious complications in children with malignant bone tumors: a multicenter nationwide study</p>

Czyżewski¹,

Gałązka²,

Zalas‐Więcek³

et al. 2019

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Objectives: The analysis of epidemiology, risk factors and outcome of infections in children with malignant bone tumors (MBT) undergoing chemotherapy. Methods: In this retrospective nationwide multicenter cross-sectional study, a total number of 126 children with MBT including 70 with Ewing sarcoma (ES) and 56 with osteosarcoma (OSA) were screened for infections over a period of 72 consecutive months. Results: The risk of infection was 7.15-fold higher in patients with ES as compared to the OSA group, especially concerning bacterial infections (4.1-fold increase risk). Bacterial infections occurred in 74.3% patients with ES and in 41.1% with OSA. The median time from diagnosis to first infection was 4.9 months. 33.0% of bacterial episodes were diagnosed as bloodstream (BSI), 31.1% as gastrointestinal tract, 30.1% as urinary tract infection. Infection-related mortality (IRM) from bacterial infection was 6% and 15% in ES and OSA patients, respectively. Cumulative incidence was 7.1% for invasive fungal disease and 6.3% for viral infections. The only significant risk factor for IRM was time to infection ≥5 months since the beginning of chemotherapy. All patients who have died from infection had BSI and were in neutropenia. Conclusions: Infections in the children with MBT in our study occurred with high frequency, especially in patients with ES. The most frequent were bacterial infections, while fungal and viral infections were episodic. Among the bacterial infections, bloodstream, urinary tract and gastrointestinal tract infections occurred with similar frequency. All deceased patients died due to BSI. Bacterial infection occurring ≥5 months since the beginning of chemotherapy was a risk factor for death.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%