Computed Tomography-Guided Radiofrequency Ablation of Malignant Lung Lesions: Early Experience

Galbis-Caravajal, José M.; Pallardó-Calatayud, Yolanda; Revert-Ventura, Antonio; Sales-Badía, Jesús G.; Esturi-Navarro, Rafael; Cuenca-Torres, María

doi:10.1016/s1579-2129(08)60063-4

Cited by 3 publications

(2 citation statements)

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“…However, most of the studies previously published have also dealt with heterogeneous and small populations. 18,20,21,28,33 The most obvious explanation for this is that RFA is still not a fully implemented treatment for lung cancer, making it difficult to enrol in a study a significant number of patients with similar characteristics. In addition, the most important criteria for RFA is contraindication for surgery, which encompasses a vast group of patients.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12][13][14] Among these interventional radiological procedures, radiofrequency ablation (RFA) is a recently developed technique and there is growing scientific evidence supporting its use for primary and secondary lung tumours treatment. [15][16][17][18][19][20][21][22][23][24] RFA destroys lung tumours via tissue heating, which is attained by the delivery of hot thermal energy through percutaneous needles, inserted under computed tomography guidance. Immediate cell death occurs when tissue temperatures reach more than 60º C. 25 RFA can be performed under conscious sedation and the incidence of side effects is quite low.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and Safety of Percutaneous Radiofrequency Thermal Ablation in the Treatment of Lung Cancer Lesions

et al. 2015

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Introduction: In this study, we reviewed a clinical series composed by all malignant lung lesions submitted to computed tomographyguided percutaneous thermal radiofrequency ablation, in our hospital, a rather recent technique that has been gaining scientific recognition. Material and Methods: For data purposes, all radiofrequency ablation and corresponding clinical records were retrospectively analysed. A computed tomography scan was performed before and after each procedure to evaluate the tumour’s features, and at a second step to assess results and complications. The frequency of local recurrence and disease progression were determined based on imaging follow-up. Kaplan–Meier analysis was used to estimate survival. Univariate analysis recognized clinical and pathological factors affecting survival. These were also tested by multivariate analysis. Results: A total of 28 malignant lung lesions, 20 primary and 8 metastatic, from 28 patients (78.6% male; mean age 62 ± 17 years old), were submitted to computed tomography-guided radiofrequency ablation between January 2004 and July 2010. Total necrosis was achieved in 74.1% of the lesions. Immediate radiofrequency ablation-related complications were observed in half of the procedures. Among major complications, death occurred in one patient only. Median overall survival was 43.0 months for a mean 2-years follow-up. Median progression-free survival was 31.6 months. Lesion’s size smaller than 35 mm, stage III disease by the TNM classification and previous treatment attempts were significantly associated with better outcomes. Disease-related mortality was 46.4%. Discussion: This procedure proved to be efficient to treat lung cancerous lesions, with a low-rate of major complications. Conclusions: Computed tomography-guided percutaneous radiofrequency ablation is a minimally invasive procedure that appears to be valuable in the treatment of lung cancer lesions. Keywords: Catheter Ablation; Lung Neoplasms; Tomography, X-Ray Computed.

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