Computational simulation of simultaneous cortical and trabecular bone change in human proximal femur during bone remodeling

Jang, In Gwun; Kim, Il Yong

doi:10.1016/j.jbiomech.2009.08.012

Cited by 57 publications

(48 citation statements)

References 43 publications

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“…particularly their simultaneous evolution with age or loading conditions [136,137]. Stochastic continuum approaches have also been added to predict the spatially diverse properties of bone.…”

Section: Bonementioning

confidence: 99%

“…These continuum models have been implemented as both 2D and 3D finite element models [138,139] for predicting age-related decrease of bone mass and strength. Most recently, Jang and Kim [137] developed a computational framework that simulated the simultaneous adaptation of cortical and trabecular bone types in human proximal femur with age. Results from the study are given in Figure 24 which shows the strain energy distribution contour plots.…”

Section: Bonementioning

confidence: 99%

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Virtual testing of advanced composites, cellular materials and biomaterials: A review

Okereke

Akpoyomare

Bingley

2014

Composites Part B: Engineering

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Please cite this article as: Okereke, M.I., Akpoyomare, A.I., Bingley, M.S., Virtual testing of advanced composites, cellular materials and biomaterials: a review, Composites: Part B (2014), doi: http://dx.doi.org/10. 1016/ j.compositesb.2014.01.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThis paper documents the emergence of virtual testing frameworks for prediction of the constitutive responses of engineering materials. A detailed study is presented, of the philosophy underpinning virtual testing schemes: highlighting the structure, challenges and opportunities posed by a virtual testing strategy compared with traditional laboratory experiments. The virtual testing process has been discussed from atomistic to macrostructural lengthscales of analyses. Several implementations of virtual testing frameworks for diverse categories of materials are also presented, with particular emphasis on composites, cellular materials and biomaterials (collectively described as heterogeneous systems, in this context). The robustness of virtual frameworks for prediction of the constitutive behaviour of these materials is discussed. The paper also considers the current thinking on developing virtual laboratories in relation to availability of computational resources as well as the development of multi-scale material model algorithms. In conclusion, the paper highlights the challenges facing developments of future virtual testing frameworks. This review represents a comprehensive documentation of the state of knowledge on virtual testing from microscale to macroscale length scales for heterogeneous materials across constitutive responses from elastic to damage regimes.

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Section: Bonementioning

confidence: 99%

Section: Bonementioning

confidence: 99%

Virtual testing of advanced composites, cellular materials and biomaterials: A review

Okereke

Akpoyomare

Bingley

2014

Composites Part B: Engineering

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“…This was applied at first for external remodelling Garcia et al 2001) and more recently has been used to attempt to reproduce realistic trabecular structures through micro-FE and design space optimisation (DSO), first in two dimensions (Jang and Kim 2010) and then in 3D (Boyle and Yong Kim 2011).…”

Section: Introductionmentioning

confidence: 99%

Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur

Dickinson

2015

Biomech Model Mechanobiol

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Bone morphology and density changes are commonly observed following joint replacement, and may contribute to the risks of implant loosening and periprosthetic fracture, and reduce the available bone stock for revision surgery. This study was presented in the "Bone and Cartilage Mechanobiology across the scales" WCCM symposium to review the development of remodelling prediction methods and to demonstrate simulation of adaptive bone remodelling around hip replacement femoral components, incorporating intrinsic (prosthesis) and extrinsic (activity and loading) factors.An iterative bone remodelling process was applied to finite element models of a femur implanted with a cementless THR (total hip replacement) and a hip resurfacing implant. Previously developed for a cemented THR implant, this modified process enabled the influence of pre-to postoperative changes in patient activity and joint loading to be evaluated. A control algorithm used identical pre-and postoperative conditions, and the predicted extents and temporal trends of remodelling were measured by generating virtual x-rays and DXA scans.The modified process improved qualitative and quantitative remodelling predictions for both the cementless THR and resurfacing implants, but demonstrated the sensitivity to DXA scan region definition and appropriate implant-bone position and sizing. Predicted remodelling in the intact femur in response to changed activity and loading demonstrated that in this simplified model, although the influence of the extrinsic effects were important, the mechanics of implantation were dominant. This study supports the application of predictive bone remodelling as one element in the range of physical and computational studies, which should be conducted in the pre-clinical evaluation of new prostheses.

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“…Research aimed at applying topology optimization theory to bone remodeling can be found in, e.g., recent work by Jang and Kim [11,12,13], while studies with the converse aim, i.e., applying bone remodeling theories in structural and topology optimization, can be found in Penninger et al [19] and Andreaus et al [1]. The theoretical basis for this connection of theories is independently discussed in Jang et al [14] and Klarbring and Torstenfelt [15,16].…”

Section: Introductionmentioning

confidence: 99%

Lazy zone bone remodeling theory and its relation to topology optimization

Klarbring

Torstenfelt

2012

Ann. Solid Struct. Mech.

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The connection between apparent density-type bone remodeling theories and density formulations of topology optimization is well known from a large number of publications and its theoretical basis has recently been discussed by making use of a dynamical systems approach to optimization. The present paper takes this connection one step further by showing how the Coleman-Noll procedure of rational thermodynamics can be used to derive general dynamical systems, where a special case includes the lazy zone concept of bone remodeling theory. It is also shown how a numerical solution method for the dynamical system can be developed by using the sequential convex approximation idea. The method is employed to obtain a series of solutions that show the influence of modeling parameters representing elements of plasticity and viscosity in the growth process.

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Computational simulation of simultaneous cortical and trabecular bone change in human proximal femur during bone remodeling

Cited by 57 publications

References 43 publications

Virtual testing of advanced composites, cellular materials and biomaterials: A review

Virtual testing of advanced composites, cellular materials and biomaterials: A review

Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur

Lazy zone bone remodeling theory and its relation to topology optimization

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