Computational selections of terpenes present in the plant Calotropis gigantea as mosquito larvicide’s by blocking the sterol carrying protein, AeSCP-2

Kumar, Pradeep; Chezhian, A.; Raja, P.; Sathiyapriya, J.

doi:10.3329/bjp.v7i1.8414

Cited by 7 publications

(4 citation statements)

References 13 publications

(10 reference statements)

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“…5 ml of each extract was mixed in 2ml of chloroform, and concentrated H2SO4 (3ml) was added carefully to form a layer. A reddish brown colouration of the inter face was formed to show the presence of terpenoids [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Molecular docking analysis of GC-MS analyzed bioactive compounds from the rhizome of Hedychium rubrum with four protein targets

Devi¹

2022

Bioinformation

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Hedychium rubrum, a traditional medicinal plant of Manipur belonging to the family Zingeberaceae was screened for its biological activity. The methanolic extract of its rhizome was prepared by Soxhlet extraction method and was further subjected to GC-MS to know its bioactive compounds. The in vitro antimicrobial activity assay was tested against five bacteria causing UTI. Klebseilla pneumoniae showed most sensitive followed by Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Enterococcus faecalis in the order. Plant extract showed higher inhibition zone than the positive control used. According to the higher quality of compounds from the GCMS results nine compounds were selected for further in silico studies using GOLD software against four protein targets. The phytoconstituents present in the methanolic extract have the ability to bind at the receptor site of all four targeted proteins. ADMET and TOPKAT studies were also carried out.

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Section: Methodsmentioning

confidence: 99%

Molecular docking analysis of GC-MS analyzed bioactive compounds from the rhizome of Hedychium rubrum with four protein targets

Devi¹

2022

Bioinformation

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“…Alpha-mangostin and panthenol isolated from Garcinia mangostana have been identified based on molecular docking method and this shows the potential of these plant-derived chemicals to bind with AeSCP-2 and inhibit its action [5]. Furthermore, the same technique revealed that the terpene, α -amyrin extracted from Calotropis gigantea , has an effective AeSCP-2 inhibitory potential [50].…”

Section: Sterol Carrier Protein-mediated Cholesterol Uptake and Itmentioning

confidence: 99%

Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives

Perera

Wijerathna

2019

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Cholesterol is one of the most vital compounds for animals as it is involved in various biological processes and acts as the structural material in the body. However, insects do not have some of the essential enzymes in the cholesterol biosynthesis pathway and this makes them dependent on dietary cholesterol. Thus, the blocking of cholesterol uptake may have detrimental effects on the survival of the insect. Utilizing this character, certain phytochemicals can be used to inhibit mosquito sterol carrier protein-2 (AeSCP-2) activity via competitive binding and proven to have effective insecticidal activities against disease-transmitting mosquitoes and other insect vectors. A range of synthetic compounds, phytochemicals, and synthetic analogs of phytochemicals are found to have AeSCP-2 inhibitory activity. Phytochemicals such as alpha-mangostin can be considered as the most promising group of compounds when considering the minimum environmental impact and availability at a low cost. Once the few limitations such as very low persistence in the environment are addressed successfully, these chemicals may be used as an effective tool for controlling mosquitoes and other disease-transmitting vector populations.

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“…Actualmente, la mayoría de los blancos propuestos para el control de Ae. aegypti, se encuentra en forma cristalizada, registrada en bases de datos como la del Proteín Data Bank (PDB) (145,148,152). En el caso de otros géneros y especies, las secuencias aminoacídicas de estas proteínas se encuentran en bases de datos como las del National Center for Biotechnology Information (NCBI).…”

Section: Mecanismo De Acciónunclassified

Essential oils and their components as an alternative in the control of mosquito vectors of disease

et al. 2017

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: diseño del trabajo, revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Benjamín Nogueda-Torres: diseño del trabajo, revisión sistemática de la actividad de los componentes Alejandro D. Camacho: revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Guadalupe Virginia Nevárez-Moorillón: revisión sistematica de la actividad biológica de los aceites esenciales, revisión de los estudios de simulación computacional y modelado molecular de los sesquiterpenos y dianas biológicas, y revisión del manuscrito Luvia E. Sánchez-Torres: revisión sistemática de la actividad de los componentes y escritura del manuscrito Sergio Andrade-Ochoa participó en todas las étapas del estudio. Essential oils and their components as an alternative in the control of mosquito vectors of diseaseMore than half of the human population is exposed to mosquito-borne infections. Climate change and the emergence of strains resistant to traditionally used insecticides have motivated the search of new agents for mosquito population control. Essential oils have been effective repellents and larvicidal agents. The aim of this work was to review research studies conducted in recent years on the larvicidal activity of essential oils and their components against Aedes, Anopheles and Culex mosquitoes, as well as the latest reports about their possible mechanism of action. Más de la mitad de la población humana está expuesta a contraer infecciones transmitidas por mosquitos. La falta de tratamientos y vacunas eficaces para muchas de estas enfermedades hace que su control dependa principalmente de la utilización de agentes insecticidas (1). Los individuos que habitan en las áreas tropicales están más expuestos a contraer enfermedades transmitidas por vectores y este riesgo ha aumentado en otras zonas debido a la globalización (2).Culex, Aedes y Anopheles son vectores de diversas enfermedades, como la filariasis, el dengue, la malaria, y otras. Culex quinquefasciatus está presente en vastas regiones tropicales del mundo, es la principal plaga doméstica en muchas áreas urbanas y está implicada en la transmisión de muchos agentes patógenos, entre ellos, el causante de la filariasis linfática. Esta enfermedad está ampliamente distribuida en las zonas tropicales, con alrededor de 120 millones de personas infectadas en todo el mundo (3).

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Computational selections of terpenes present in the plant Calotropis gigantea as mosquito larvicide’s by blocking the sterol carrying protein, AeSCP-2

Cited by 7 publications

References 13 publications

Molecular docking analysis of GC-MS analyzed bioactive compounds from the rhizome of Hedychium rubrum with four protein targets

Molecular docking analysis of GC-MS analyzed bioactive compounds from the rhizome of Hedychium rubrum with four protein targets

Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives

Essential oils and their components as an alternative in the control of mosquito vectors of disease

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