2017
DOI: 10.1002/cnm.2944
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Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms

Abstract: Dissections of ascending thoracic aortic aneurysms (ATAAs) cause significant morbidity and mortality worldwide. They occur when a tear in the intima-media of the aorta permits the penetration of the blood and the subsequent delamination and separation of the wall in 2 layers, forming a false channel. To predict computationally the risk of tear formation, stress analyses should be performed layer-specifically and they should consider internal or residual stresses that exist in the tissue. In the present paper, … Show more

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Cited by 21 publications
(22 citation statements)
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References 88 publications
(222 reference statements)
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“…The peak wall stress could reach values over 500 kPa at hot spots of the inner curvature. These results were also confirmed by Mousavi et al [48], who proposed a layer-specific damage model to computationally predict the risk of tear formation. Alford & Taber [51] had shown earlier that in the aortic arch, like in a torus, compared to the basal circumferential stress of a cylinder of similar diameter, the circumferential stress at the inner curvature increases while the stress at the outer curvature decreases.…”
Section: Discussionsupporting
confidence: 77%
“…The peak wall stress could reach values over 500 kPa at hot spots of the inner curvature. These results were also confirmed by Mousavi et al [48], who proposed a layer-specific damage model to computationally predict the risk of tear formation. Alford & Taber [51] had shown earlier that in the aortic arch, like in a torus, compared to the basal circumferential stress of a cylinder of similar diameter, the circumferential stress at the inner curvature increases while the stress at the outer curvature decreases.…”
Section: Discussionsupporting
confidence: 77%
“…Mesh-dependence issues are addressed by a non-local gradient-enhanced approach and a new adaptive fibre deposition approach has been integrated into the non-local healing model. Important developments are currently in progress for applying the proposed model to different applications, such as balloon angioplasty [45] or prediction of aneurysm rupture [46]. Competing interests.…”
Section: Discussionmentioning
confidence: 99%
“…Damage has been a topic of intense research in computational mechanics of soft tissues and arteries [29]- [35]. However, authors usually investigated mechanically induced damage in situations of overloading preceding rupture [36]. In aneurysms, damage would rather be induced chemically and occur progressively.…”
Section: Discussionmentioning
confidence: 99%