Computational Modeling of Gastrointestinal Fluid Dynamics

Ferrua, Maria J.; Singh, R. Paul

doi:10.1007/978-94-007-6561-0_13

Cited by 7 publications

(2 citation statements)

References 63 publications

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“…Computational modeling of intestinal fluid flow volumes can permit the evaluation of device retention mechanisms in the gut under varying volume conditions. 120,121 Additionally, finite element analysis has been effectively employed to assess the penetration capacity of mechano-adhesive gastroretentive devices, such as theragrippers 90 and kirigami-inspired stents, 122 designed for targeted local delivery of therapeutics. These computational techniques allow for the incorporation of diverse morphological conditions, considering factors like patients' age and the specific section within the small intestine.…”

Section: Complexity Of Intestinal Environmentmentioning

confidence: 99%

Intestinal retentive systems – recent advances and emerging approaches

Naik,

Matonis,

Balakrishnan

et al. 2024

J. Mater. Chem. B

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Section: Complexity Of Intestinal Environmentmentioning

confidence: 99%

Intestinal retentive systems – recent advances and emerging approaches

Naik,

Matonis,

Balakrishnan

et al. 2024

J. Mater. Chem. B

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“…In silico approach is based in computer modelling and aims at producing algorithms or numerical models able to predict the drug effects. They have different level of complexity and include computational fluid dynamics (CFD) 21 , ordinary differential equations (ODEs) 22 , 23 , aged-based modelling (ABM) 24 , 25 , and genome scale modelling (GSM) 26 . For the development of in silico models, it is critical the reliability of input data that are coming from databases, data banks, data mining, data analysis tools, publications, homology models, and other repositories 27 .…”

Section: Translational Potentials and Challenges Of Current Gut Modelsmentioning

confidence: 99%

The translational roadmap of the gut models, focusing on gut-on-chip

Malaguarnera¹,

Graute²,

Homs-Corbera³

2023

Open Res Europe

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It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational research with a focus on gut-on-chip. These micro physiological systems (MPS) are microfluidic devices that recapitulate in vitro the physiology of the intestine. We reviewed the gut-on-chips that had been developed in academia and industries as single chip and that have three main purpose: replicate the intestinal physiology, the intestinal pathological features, and for pharmacological tests.

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Models of the Gut for Analyzing the Impact of Food and Drugs

Fois

Schindeler

et al. 2019

Adv Healthcare Materials

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The human intestine is the primary organ responsible for the uptake of nutrients and water, and this is facilitated by its complex structure that features a large surface area. With an average total length of around seven meters, including both small and large intestine, it connects the stomach to the rectum while enabling absorption in a specialized manner. At a cellular level, the gut epithelium is critical in selective transport to the bloodstream. The finger-like projections of the intestinal epithelium Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.

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Computational Modeling of Gastrointestinal Fluid Dynamics

Cited by 7 publications

References 63 publications

Intestinal retentive systems – recent advances and emerging approaches

Intestinal retentive systems – recent advances and emerging approaches

The translational roadmap of the gut models, focusing on gut-on-chip

Models of the Gut for Analyzing the Impact of Food and Drugs

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