Computational modeling of electric fields for prefrontal tDCS across patients with schizophrenia and mood disorders

Uenishi, Shinya; Tamaki, Atsushi; Yamada, Shinichi; Yasuda, Kasumi; Ikeda, Natsuko; Mizutani-Tiebel, Yuki; Keeser, Daniel; Padberg, Frank; Tsuji, Takao; Kimoto, Sohei; Takahashi, Shun

doi:10.1016/j.pscychresns.2022.111547

Cited by 4 publications

(2 citation statements)

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“…13 The theoretical effectiveness of stimulation over the aforementioned frontopolar area had been addressed in several reports. [14][15][16][17] To address the mixed findings in the literature, researchers have conducted traditional pairwise meta-analyses. 18,19 However, because of methodological limitations, they have only completed head-to-head comparisons and have not distinguished between the therapeutic effects of different NIBS protocols.…”

Section: Limitationsmentioning

confidence: 99%

“…An RCT by Boggio et al 13 found that excitatory rTMS over the right DLPFC exerted a greater treatment effect than did excitatory rTMS over the left DLPFC 13 . The theoretical effectiveness of stimulation over the aforementioned frontopolar area had been addressed in several reports 14–17 . To address the mixed findings in the literature, researchers have conducted traditional pairwise meta‐analyses 18,19 .…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and acceptability of noninvasive brain stimulation for treating posttraumatic stress disorder symptoms: A network meta‐analysis of randomized controlled trials

Tseng,

Zeng,

Wang

et al. 2024

Acta Psychiatr Scand

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IntroductionDespite its high lifetime prevalence rate and the elevated disability caused by posttraumatic stress disorder (PTSD), treatments exhibit modest efficacy. In consideration of the abnormal connectivity between the dorsolateral prefrontal cortex (DLPFC) and amygdala in PTSD, several randomized controlled trials (RCTs) addressing the efficacy of different noninvasive brain stimulation (NIBS) modalities for PTSD management have been undertaken. However, previous RCTs have reported inconsistent results. The current network meta‐analysis (NMA) aimed to compare the efficacy and acceptability of various NIBS protocols in PTSD management.MethodsWe systematically searched ClinicalKey, Cochrane Central Register of Controlled Trials, Embase, ProQuest, PubMed, ScienceDirect, Web of Science, and ClinicalTrials.gov to identify relevant RCTs. The targeted RCTs was those comparing the efficacy of NIBS interventions, such as transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and transcutaneous cervical vagal nerve stimulation, in patients with PTSD. The NMA was conducted using a frequentist model. The primary outcomes were changes in the overall severity of PTSD and acceptability (to be specific, rates of dropouts for any reason).ResultsWe identified 14 RCTs that enrolled 686 participants. The NMA demonstrated that among the investigated NIBS types, high‐frequency rTMS over bilateral DLPFCs was associated with the greatest reduction in overall PTSD severity. Further, in comparison with the sham controls, excitatory stimulation over the right DLPFC with/without excitatory stimulation over left DLPFC were associated with significant reductions in PTSD‐related symptoms, including depression and anxiety symptoms, and overall PTSD severity.ConclusionsThis NMA demonstrated that excitatory stimulation over the right DLPFC with or without excitatory stimulation over left DLPFC were associated with significant reductions in PTSD‐related symptoms.Trial registration: PROSPERO CRD42023391562.

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