Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study

Van Hoornweder, Sybren; Nuyts, Marten; Frieske, Joana; Verstraelen, Stefanie; Meesen, Raf L.J.; Caulfield, Kevin A.

doi:10.1016/j.neuroimage.2023.120379

Cited by 5 publications

(3 citation statements)

References 212 publications

(104 reference statements)

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“…Nevertheless, the studies that did use finite-element method-based electric field calculations showed activation peaks in the IPS higher than what is recommended (0.017 mA/cm 2 ) to modify cortical excitability by tDCS in humans ( Klein et al, 2013a , b ; Artemenko et al, 2015 ; Hauser et al, 2016 ; Bieck et al, 2018 ; Zhang et al, 2022 ). It is essential for future studies to perform subject-specific electric field simulation to select the optimal current dose and pinpoint cortical areas that are likely to be activated by tES ( Kashyap et al, 2021 ; Van Hoornweder et al, 2023 ). Techniques such as transcranial-focused ultrasound, transcranial temporal interference stimulation, and transcutaneous vagus nerve stimulation that offer superior spatial resolution and penetration depth compared with conventional stimulation paradigms could also potentially resolve the focality issue in future studies.…”

Section: Discussionmentioning

confidence: 99%

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

Fresnoza,

Ischebeck

2024

eNeuro

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This systematic review presented a comprehensive survey of studies that applied transcranial magnetic stimulation and transcranial electrical stimulation to parietal and nonparietal areas to examine the neural basis of symbolic arithmetic processing. All findings were compiled with regard to the three assumptions of the triple-code model (TCM) of number processing. Thirty-seven eligible manuscripts were identified for review (33 with healthy participants and 4 with patients). Their results are broadly consistent with the first assumption of the TCM that intraparietal sulcus both hold a magnitude code and engage in operations requiring numerical manipulations such as subtraction. However, largely heterogeneous results conflicted with the second assumption of the TCM that the left angular gyrus subserves arithmetic fact retrieval, such as the retrieval of rote-learned multiplication results. Support is also limited for the third assumption of the TCM, namely, that the posterior superior parietal lobule engages in spatial operations on the mental number line. Furthermore, results from the stimulation of brain areas outside of those postulated by the TCM show that the bilateral supramarginal gyrus is involved in online calculation and retrieval, the left temporal cortex in retrieval, and the bilateral dorsolateral prefrontal cortex and cerebellum in online calculation of cognitively demanding arithmetic problems. The overall results indicate that multiple cortical areas subserve arithmetic skills.

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Section: Discussionmentioning

confidence: 99%

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

Fresnoza,

Ischebeck

2024

eNeuro

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“…Nevertheless, it is still possible that the electric field can have a larger effect than that reported in our study, but it remains an open question how the electric field data should be processed to obtain key values having good predictive power for tDCS responses. 34 …”

Section: Discussionmentioning

confidence: 99%

Small effects of electric field on motor cortical excitability following anodal tDCS

Laakso,

Tani,

Gomez-Tames

et al. 2024

iScience

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“…On the other hand, our study defines focality as a whole-brain metric based on the volume of GM with EF magnitude above 75% and 50% of the maximum EF (99.9th percentile), an intuitive and wider use metric in the tDCS field (Mikkonen et al 2020, Antonenko et al 2021, Van Hoornweder et al 2023, which has allowed us to quantify a global effect of change across subjects and montages (see figure 5). However, we acknowledge that other measures, such as the dose-target determination index (DTDI) proposed in Kashyap et al (2021).…”

Section: Methodological Considerationsmentioning

confidence: 99%

How does the electric field induced by tDCS influence motor-related connectivity? Model-guided perspectives

Fernandes,

Callejón-Leblic,

Ferreira

2024

Phys. Med. Biol.

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Over the last decade, Transcranial Direct Current Stimulation (tDCS) has been applied not only to modulate local cortical activation, but also to address communication between functionally-related brain areas. Stimulation protocols based on simple two-electrode placements are being replaced by multi-electrode montages to target intra- and inter-hemispheric neural networks using multichannel/high definition paradigms. Objective: This study aims to investigate the characteristics of electric field (EF) patterns originated by tDCS experiments addressing changes in functional brain connectivity. Methods: A previous selection of tDCS experimental studies aiming to modulate motor-related connectivity in health and disease was conducted. Simulations of the EF induced in the cortex were then performed for each protocol selected. The EF magnitude and orientation are determined and analysed in motor-related cortical regions for five different head models to account for inter-subject variability. Functional connectivity outcomes obtained are qualitatively analysed at the light of the simulated EF and protocol characteristics, such as electrode position, number and stimulation dosing.Main findings: The EF magnitude and orientation predicted by computational models can be related with the ability of tDCS to modulate brain functional connectivity. Regional differences in EF distributions across subjects can inform electrode placements more susceptible to inter-subject variability in terms of brain connectivity-related outcomes. Significance: Neuronal facilitation/inhibition induced by tDCS fields may indirectly influence intra and inter-hemispheric connectivity by modulating neural components of motor-related networks. Optimization of tDCS using computational models is essential for adequate dosing delivery in specific networks related to clinically relevant connectivity outcomes.

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Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study

Cited by 5 publications

References 212 publications

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

Small effects of electric field on motor cortical excitability following anodal tDCS

How does the electric field induced by tDCS influence motor-related connectivity? Model-guided perspectives

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