Computational Fluid Dynamics Study of Inlet Velocity on Extrusion-Based Bioprinting

Gómez-Blanco, J. Carlos; Sánchez, Enrique Mancha; Morán, Juan Francisco Ortega; Díaz-Parralejo, Antonio; Sánchez‐Margallo, Francisco M.; Pagador, J. Blas

doi:10.1007/978-3-030-31635-8_64

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Gómez-Blanco et al . [ 11 ] investigated the effect of inlet velocity, which is proportional to flow rate and can affect the extent of pressure endured by cells during the bioprinting process. Reina-Romo et al .…”

Section: Introductionmentioning

confidence: 99%

Computational Fluid Dynamics Assessment of the Effect of Bioprinting Parameters in Extrusion Bioprinting

Chand¹,

Muhire²,

Vijayavenkataraman³

2022

IJB

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Wall shear stress is the most critical factor in determining the viability of cells during the bioprinting process, and controlling wall shear stress remains a challenge in extrusion bioprinting. We investigated the effect of various bioprinting parameters using computational simulations on maximum wall shear stress (MWSS) in the nozzle to optimize the bioprinting process. Steady-state simulations were done for three nozzle geometries (conical, tapered conical, and cylindrical) with varying nozzle diameters (0.1 mm–0.5 mm) at different inlet pressure (0.025 MPa–0.25 MPa) as inlet conditions. Non-Newtonian power law was used to model the bioink rheology and four different bioinks with power-law constants ranging from 0.0863 to 0.5050 were examined. To capture the dynamic behavior of the bioink and the thread profile of the extruded bioink, transient simulations were carried out. Our results indicate that although the MWSS is lowest in the cylindrical nozzle, this stress condition lasts for a longer portion of the nozzle and for the same inlet pressure and nozzle diameter, the mass flow rate is lower compared to the tapered conical and conical nozzle, contributing to lower cell viability.

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Section: Introductionmentioning

confidence: 99%

Computational Fluid Dynamics Assessment of the Effect of Bioprinting Parameters in Extrusion Bioprinting

Chand¹,

Muhire²,

Vijayavenkataraman³

2022

IJB

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Optimizing Cell Deformation in Extrusion-Based Bioprinting Process by Importing Inherent Viscoelasticity Using Computational Fluid Dynamic

Das

Datta

Chowdhury

2022

Lecture Notes in Mechanical Engineering

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Design and Simulation of a Hybrid Inkjet Printhead for Ejecting High Viscous Inks

Shah,

Kim,

Haider

et al. 2024

Preprint

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Printing high-viscosity inks continues to remain a challenge in inkjet technology, and thus far, extensive numerical simulations have been performed to resolve this issue. In this paper, we present a novel hybrid inkjet printhead that combines piezoelectric and electrohydrodynamic (EHD) forces. The hybrid inkjet printhead is designed using multi-physics numerical simulation technology and by investigating jetting high-viscous ink. The proposed method enables precise control of the droplet volume and velocity. We also investigated the performance of our hybrid inkjet printhead and optimized the piezoelectric and EHD waveforms with rising, dwell, and falling times. Further, we designed an EHD driving device to generate the EHD jetting force. We used a hybrid inkjet printing simulation to jet a high-viscous ink of up to 100 cp, which confirms that the jetting performance of the hybrid inkjet printing method is superior to that of the existing piezoelectric inkjet printing methods. The proposed high-viscosity hybrid inkjet head technology can be applied to various industrial fields, including display manufacturing processes, semiconductor packaging processes, 3D printing, and manufacturing processes for biomedical artificial structures.

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Computational Fluid Dynamics Study of Inlet Velocity on Extrusion-Based Bioprinting

Cited by 4 publications

References 12 publications

Computational Fluid Dynamics Assessment of the Effect of Bioprinting Parameters in Extrusion Bioprinting

Computational Fluid Dynamics Assessment of the Effect of Bioprinting Parameters in Extrusion Bioprinting

Optimizing Cell Deformation in Extrusion-Based Bioprinting Process by Importing Inherent Viscoelasticity Using Computational Fluid Dynamic

Design and Simulation of a Hybrid Inkjet Printhead for Ejecting High Viscous Inks

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