Computational Fluid Dynamics Prediction of Blood Damage in a Centrifugal Pump

Abstract

This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. In vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. This allowed for an order of magnitude comparison between our estimations and experimentally measured hemolysis levels, which resulted in a reasonable correlation. This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagranian behavior of blood in a heart assist device.

Numerical Simulation of LVAD Inflow Cannulas with Different Tip

“…The hemolysis in the inflow cannulas is mainly caused by the high shear stress of flow in the inflow cannulas. The effective numerical prediction of mechanical hemolysis has been built [13][14][15]. In vitro and in vivo mechanical hemolysis tests have been studied previously [16][17][18].…”

A New Method for Assessing Haemolysis in a Rotary Blood Pump Using Large Eddy Simulations (LES)

“…Tavoularis et al (2003) and Yoganathan et al (2005) recognized LES as a very promising tool in modeling phenomena inside the artificial heart.…”

“…However, one can find papers in the literature concerning haemolysis inside the artificial heart. Song et al (2003) assessed haemolysis by tracking a set of particles and their stress history. They used Computational Fluid Dynamics (CFD) for this purpose.…”

“…CFD calculations refer to blood velocity distribution, mechanical stress distribution in different sites inside the artificial heart and heat exchange with external environment. The aforementioned papers of Arvand et al (2001) and Song et al (2003) also concern haemolysis assessment inside the artificial heart. However, their approach differs from the approach presented in this paper.…”

Modelagem matemática da fluidodinâmica não-newtoniana e bifásica simplificada da hemólise induzida mecanicamente em sistemas de bombeamento centrífugo de sangue

“…Alguns aprimoramentos baseados nos modelos de lei de potências foram propostos. Uma das vertentes destes aprimoramentos consiste em acompanhar hemácias ao longo de suas trajetórias no interior de dispositivos artificiais, calculando-se a hemólise induzida mecanicamente acumulada ao longo desse caminho, através de uma integração numérica linear , (Bludszuweit, 1995a), (Bludszuweit, 1995b), (Chan et al, 2002), (De Wachter e Verdonck, 2002), , , , (Song et al, 2003b), (Goubergrits e Affeld, 2004), (Arvand et al, 2005), (Gu e Smith, 2005), (Grigioni et al, 2005), (Goubergrits, 2006), (Throckmorton e Untaroiu, 2008), (Arwatz e Smits, 2013).…”