Computational fluid dynamics in coronary artery disease

Sun, Zhonghua; Xu, Lei

doi:10.1016/j.compmedimag.2014.09.002

Cited by 50 publications

(36 citation statements)

References 142 publications

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“…In the past decades, computational fluid dynamics (CFD) has emerged as a powerful and popular tool for the study of blood flow dynamics of aneurysms and other cardiovascular disease [5][6][7][8]. With appropriate boundary conditions and model assumptions, CFD can simulate the blood flow through any vessel of the body using patient-specific geometries, typically derived from computed tomography (CT).…”

Section: Introductionmentioning

confidence: 99%

A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm

Kelsey

Powell

Norman

et al. 2016

Numer Methods Biomed Eng

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Aneurysms of the common iliac artery (CIAA) are most commonly seen in association with an abdominal aortic aneurysm (AAA). Isolated CIAAs, in the absence of an AAA, are uncommon. Similar to AAAs, CIAA may develop intraluminal thrombus (ILT). As isolated CIAAs have a contralateral common iliac artery for comparison, they provide an opportunity to study the haemodynamic mechanisms behind ILT formation.In this study, we compared a large isolated CIAA and the contralateral iliac artery using computational fluid dynamics (CFD) to determine if haemodynamic metrics correlate with the location of ILT. We performed a comprehensive CFD study and investigated the residence time of platelets and monocytes, velocity fields, time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and endothelial cell activation potential (ECAP). We then correlated these data to ILT burden determined with computed tomography (CT).We found that high cell residence times, low TAWSS, high OSI and high ECAP all correlate with regions of ILT development. Our results show agreement with previous hypotheses of thrombus formation in AAA and provide insights into the computational haemodynamics of iliac artery aneurysms.

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Section: Introductionmentioning

confidence: 99%

A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm

Kelsey

Powell

Norman

et al. 2016

Numer Methods Biomed Eng

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“…There is a large variation of α in patients in the range from 53 to 120 degrees. For modeling the flow a pulsating volume flux [3] as shown in fig. 1 (right) was set.…”

Section: Modeling Approachesmentioning

confidence: 99%

Influence of Hemorheology on Nanoparticle Transport in Vessel Bifurcations

Bavandi

Wünsch

2018

Proc Appl Math and Mech

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This study presents the effect of hemorheology on nanoparticle transport in the left coronary artery. The flow is considered to be pulsating and particles are modeled by concentration equation. The influence of Newtonian and non-Newtonian modeling approaches on particle transport is investigated and compared. Three bifurcations are investigated to determine the effect of bifurcation angles. The results show that considering blood as non-Newtonian in certain configurations is necessary.

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“…[8,18] Recently, hydrogels À swollen networks of hydrophilic polymer À have emerged as a viable material solution for mechanical devices. For instance, polyacrylamide (PAAm)-based hydrogels have been widely used as elastomeric matrices due to their high toughness and extensibility, as well as optical transparency.…”

Section: Introductionmentioning

confidence: 99%

Selective Mineralization of Tough Hydrogel Lumens for Simulating Arterial Plaque

et al. 2016

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This paper demonstrates progress of fabricating artificial arteries (phantoms) that mimic plaque buildup. Hydrogel lumens are molded using tough polyacrylamide with regions selectively mineralized with calcium phosphate. By tuning the degree of mineralization such as calcium concentration ([Ca 2þ ], 0.4-2 M), and crystallization time (t c , 1-4 weeks), the authors control the extent of lumen occlusion. These occluded lumens significantly reduce pressure (DP % 7.79 kPa) during fluid flow compared to the non-calcified lumens (DP % 1.24 kPa). Additionally, image, chemical analysis, and compressive mechanical tests are performed to determine the effect of synthesis conditions on the composite's mechanical properties. For comparison to real arteries, the authors also present dynamic mechanical analysis of human aortic tissue.

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Computational fluid dynamics in coronary artery disease

Cited by 50 publications

References 142 publications

A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm

A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm

Influence of Hemorheology on Nanoparticle Transport in Vessel Bifurcations

Selective Mineralization of Tough Hydrogel Lumens for Simulating Arterial Plaque

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