Computational-Based Approach for Predicting Porosity of Electrospun Nanofiber Mats Using Response Surface Methodology and Artificial Neural Network Methods

Moghadam, Bentolhoda Hadavi; Haghi, A. K.; Kasaei, Shohreh; Hasanzadeh, Mahdi

doi:10.1080/00222348.2015.1090654

Cited by 14 publications

(10 citation statements)

References 36 publications

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“…The cellulose nanofiber-membranes, polysulfone nanofiber-membranes, and control membranes had MWCOs greater than 95 kDa, which is consistent with the values previously reported by Millipore . Nanofiber layers have porosities greater than 80% and calculated intrafiber spacings of 3 μm . Our retained MWCO data suggest that the small membrane pores (18.0 ± 8 nm) remained accessible and continued to control the size selectivity of the membranes.…”

Section: Resultsmentioning

confidence: 67%

“…The cellulose nanofiber-membranes, polysulfone nanofiber-membranes, and control membranes had MWCOs greater than 95 kDa, which is consistent with the values previously reported by Millipore. 52 Nanofiber layers have porosities greater than 80% 53 and calculated intrafiber spacings of 3 μm. 54 Our retained MWCO data suggest that the small membrane pores (18.0 ± 8 nm) remained accessible and continued to control the size selectivity of the membranes.…”

Section: Resultsmentioning

confidence: 97%

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Ultrafiltration Membranes Enhanced with Electrospun Nanofibers Exhibit Improved Flux and Fouling Resistance

Dobosz

Kuo-Leblanc

Martin

et al. 2017

Ind. Eng. Chem. Res.

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In this study, we have improved membrane performance by enhancing ultrafiltration membranes with electrospun nanofibers. The high-porosity nanofiber layer provides a tailorable platform that does not affect the base membrane structure. To decouple the effects that nanofiber chemistry and morphology have on membrane performance, two polymers commonly used in the membrane industry, cellulose and polysulfone, were electrospun into a layer that was 50 μm thick and consisted of randomly accumulated 1-μm-diameter fibers. Fouling resistance was improved and selectivity was retained by ultrafiltration membranes enhanced with a layer of either cellulose or polysulfone nanofibers. Potentially because of their better mechanical integrity, the polysulfone nanofiber-membranes demonstrated a higher pure-water permeance across a greater range of transmembrane pressures than the cellulose nanofiber-membranes and control membranes. This work demonstrates that nanofiber-enhanced membranes hold potential as versatile materials platforms for improving the performance of ultrafiltration membranes.

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Section: Resultsmentioning

confidence: 67%

“…The cellulose nanofiber-membranes, polysulfone nanofiber-membranes, and control membranes had MWCOs greater than 95 kDa, which is consistent with the values previously reported by Millipore. 52 Nanofiber layers have porosities greater than 80% 53 and calculated intrafiber spacings of 3 μm. 54 Our retained MWCO data suggest that the small membrane pores (18.0 ± 8 nm) remained accessible and continued to control the size selectivity of the membranes.…”

Section: Resultsmentioning

confidence: 97%

Ultrafiltration Membranes Enhanced with Electrospun Nanofibers Exhibit Improved Flux and Fouling Resistance

Dobosz

Kuo-Leblanc

Martin

et al. 2017

Ind. Eng. Chem. Res.

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“…Electrospinning is a scalable and versatile technique for producing highly porous materials that exhibit outstanding structure–property relationships. , The produced mats are composed of nano- and macroscale diameter fibers, which have microscale interstitial spacing, a large surface-to-volume ratio, high specific surface area, and porosity values greater than 80%. , By coupling their unique structural characteristics with an optimized surface chemistry, electrospun fiber mats are promising for applications ranging from tissue engineering, , to wearable electronics, to water purification technologies. , Unfortunately, these materials are susceptible to biofouling, which can cause detrimental complications, such as reduced efficiency and selectivity of membranes and infections from contaminated medical devices …”

Section: Introductionmentioning

confidence: 99%

Antifouling Electrospun Nanofiber Mats Functionalized with Polymer Zwitterions

Kolewe

Dobosz²,

Rieger³

et al. 2016

ACS Appl. Mater. Interfaces

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In this study, we exploit the excellent fouling resistance of polymer zwitterions and present electrospun nanofiber mats surface-functionalized with poly(2-methacryloyloxyethyl phosphorylcholine) (polyMPC). This zwitterionic polymer coating maximizes the accessibility of the zwitterion to effectively limit biofouling on nanofiber membranes. Two facile, scalable methods yielded a coating on a cellulose nanofiber platform: (i) a two-step sequential deposition featuring dopamine polymerization followed by the physioadsorption of polyMPC; and (ii) a one-step codeposition of polydopamine (PDA) with polyMPC. While the sequential and codeposited nanofiber mat assemblies have an equivalent average fiber diameter, hydrophilic contact angle, surface chemistry, and stability, the topography of nanofibers prepared by codeposition were smoother. Protein and microbial antifouling performance of the zwitterion modified nanofiber mats along with two controls, cellulose (unmodified) and PDA coated nanofiber mats were evaluated by dynamic protein fouling and prolonged bacteria exposure experiments. Following 21 days of exposure to bovine serum albumin, the sequential nanofiber mats significantly resisted protein fouling, as indicated by their 95% flux recovery ratio in a water flux experiment, 300% improvement over the cellulose nanofiber mats. When challenged with two model microbes Escherichia coli and Staphylococcus aureus for 24 hr, both zwitterion modifications demonstrated superior fouling resistance by statistically reducing microbial attachment over the two controls. This study demonstrates that by decorating the surfaces of chemically and mechanically robust cellulose nanofiber mats with polyMPC, we can generate high performance, free-standing nanofiber mats that hold potential in applications where antifouling materials are imperative, such as tissue engineering scaffolds and water purification technologies.

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“…Related research has been applied to diverse polymers, like polyacrylonitrile (PAN), PA, polystyrene (PS), poly(methyl methacrylate) (PMMA), PVDF, poly(vinyl alcohol) (PVA), poly(lactic acid) (PLA), starch, and silk fibroin. [58,[63][64][65] Through these quantitative analyses, essential characteristics of electrospun fibers, such as, fiber morphology, porosity, and roughness can be well controlled, and these studies offered an in-depth insight into the complex phenomena of electrospinning. Furthermore, these comprehensive studies based on mathematical and theoretical analyses provide a solid theoretical foundation for the stable fabrication, and industrialization of electrospinning.…”

Section: Factors For the Processing Of Electrospinningmentioning

confidence: 99%

“…RSM displayed a good accuracy in predicting the porosity while ANN can much accurately predict the contact angle. [65,113] The applied voltage and the solution concentration are key parameters that affect the porosity. The solution concentration is the critical parameter that determines the contact angle and the fiber diameter of the membrane.…”

Section: Polyacrylonitrile-based Protective Membranesmentioning

confidence: 99%

Recent Progress in Protective Membranes Fabricated via Electrospinning: Advanced Materials, Biomimetic Structures, and Functional Applications

et al. 2022

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Computational-Based Approach for Predicting Porosity of Electrospun Nanofiber Mats Using Response Surface Methodology and Artificial Neural Network Methods

Cited by 14 publications

References 36 publications

Ultrafiltration Membranes Enhanced with Electrospun Nanofibers Exhibit Improved Flux and Fouling Resistance

Ultrafiltration Membranes Enhanced with Electrospun Nanofibers Exhibit Improved Flux and Fouling Resistance

Antifouling Electrospun Nanofiber Mats Functionalized with Polymer Zwitterions

Recent Progress in Protective Membranes Fabricated via Electrospinning: Advanced Materials, Biomimetic Structures, and Functional Applications

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