Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery

Huynh, Loan; Neale, Chris; Pomès, Régis; Allen, Christine

doi:10.1016/j.nano.2011.05.006

Cited by 125 publications

(92 citation statements)

References 97 publications

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“…Moreover, the multi-functional groups (branches) endow dendrimers with special properties. Dendrimers are used in drugs delivery and carriers [3][4][5][6] , fuel cells 7 , light-emitting diodes 8,9 , liquid crystals 10 and chemical modifications 11,12 , membrane separation 13 . In nowadays, most investigators have focused their attentions on the free dendrimers, while the properties and applications of other kinds of supported dendrimers are seldom reported.…”

Section: Introductionmentioning

confidence: 99%

Investigation about the copper adsorption on the chloropropylsilica gel surface modified with a nanostructured dendrimer DAB-Am-16: an analytical application for determination of copper in different samples

Carmo

Paim

2012

Mat. Res.

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The third generation (G-3) poly(propyleneimine)hexadecaamine dendrimer (DAB-Am-16) was grafted onto the chloropropylsilica gel surface (DPPIPS). The modified silica (DPPIPS) was characterized by Electronic (Uv-Vis), vibrational and Electron Paramagnetic Resonance (EPR), spectrocopies, surface area (331.07 m 2 .g -1) and porosity analyses (pore diameter of 41.9 nm) and cyclic voltammetry technique. The copper adsorption studies were performed using a batchwise process and the DPPIPS showed adsorption capacities of 16.3, 47.8 and 659.5 mol.g -1 in aqueous, ethanol and acetone medium, respectively, with recoveries close to 100% after percolation with HCl 1.0 mol.L -1 . The results suggest that the sorption of copper ions on DPPIPS occurs mainly by surface complexation and a Langmuir model allowed describing the sorption of the metal ions on DPPIPS. As an application of this chemically modified material, copper was determined in real samples of distilled spirits and fuel alcohol.

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Section: Introductionmentioning

confidence: 99%

Investigation about the copper adsorption on the chloropropylsilica gel surface modified with a nanostructured dendrimer DAB-Am-16: an analytical application for determination of copper in different samples

Carmo

Paim

2012

Mat. Res.

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“…To facilitate design selection of the optimum system and preparation protocol, the use of in silico tools [9,23,24] (statistical methods, artificial neural networks (ANN) and especially molecular simulations) and the development of high-throughput scanning (HTS) methods (such as parallel synthesis) [11] became a necessity.…”

Section: Polymers In Controlled Delivery Systemsmentioning

confidence: 99%

“…To reduce financial and time costs of experimentation, the elaboration of theoretical models is also highly desirable. The models are extremely helpful tools, useful in preliminary screenings, prediction of a series of properties and interactions, as well as in identifying possible causes of potential failures [9]. Finally, protocols and technologies, both reproducible and environmentally friendly [5,10], have to be developed for the manufacturing of the product.…”

Section: Introductionmentioning

confidence: 99%

Polymer engineering for drug/gene delivery: from simple towards complex architectures and hybrid materials

David

Fundueanu²,

Pinteala³

et al. 2014

Pure and Applied Chemistry

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“…55 Similarly, it can be associated with the recording and analysis of experimental test results from the delivery of nanoparticles to different biomedical and ecological targets and contexts 56 (eventually taking organism-microbiome interactions into account).…”

Section: Nanotechnology and Nanoinformaticsmentioning

confidence: 99%

Nanoinformatics: a new area of research in nanomedicine

Maojo¹,

Fritts²,

Iglesia³

et al. 2012

IJN

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Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, with the management and integration of heterogeneous information, defining nomenclatures, taxonomies and classifications for various types of nanomaterials, and research on new modeling and simulation techniques for nanoparticles. Nanoinformatics has recently emerged in the USA and Europe to address these issues. In this paper, we present a review of nanoinformatics, describing its origins, the problems it addresses, areas of interest, and examples of current research initiatives and informatics resources. We suggest that nanoinformatics could accelerate research and development in nanomedicine, as has occurred in the past in other fields. For instance, biomedical informatics served as a fundamental catalyst for the Human Genome Project, and other genomic and -omics projects, as well as the translational efforts that link resulting molecular-level research to clinical problems and findings.

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Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery

Cited by 125 publications

References 97 publications

Investigation about the copper adsorption on the chloropropylsilica gel surface modified with a nanostructured dendrimer DAB-Am-16: an analytical application for determination of copper in different samples

Investigation about the copper adsorption on the chloropropylsilica gel surface modified with a nanostructured dendrimer DAB-Am-16: an analytical application for determination of copper in different samples

Polymer engineering for drug/gene delivery: from simple towards complex architectures and hybrid materials

Nanoinformatics: a new area of research in nanomedicine

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