Computational and experimental therapeutic efficacy analysis of andrographolide phospholipid complex self-assembled nanoparticles against Neuro2a cells

Mourya, Atul; Pingle, Purva; Babu, Chanti Katta; Hartisree, Veerabroma; Jyothi, Vaskuri G.S. Sainaga; Novak, Jurica; Pathak, Prateek; Grishina, Maria; Verma, Amita; Kumar, Rahul; Singh, Pankaj Kumar; Khatri, Dharmendra Kumar; Singh, Shashi Bala; Madan, Jitender

doi:10.1016/j.bbagen.2022.130283

Cited by 2 publications

(1 citation statement)

References 60 publications

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“…This can be particularly important for lipid based systems representative of the human cell membranes, as there are often clustering effects, and direct direct interaction of protein based biologics with non-desired membrane constituents both for targeted macromolecules and as distant effectors on other membrane proteins. For things representative of the neurological system, endocrine systems and specialized tissues utilizing membrane based signaling lipids, these can be decisive in effectiveness or off-target effects [ 34 , 92 ]. Standardized membrane models serve as a reference point to test new products safety and analysis therefore becomes standardized too.…”

Section: Analysis Of Membrane Molecular Dynamic Simulationsmentioning

confidence: 99%

Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Watkins

2023

Membranes

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There has been an almost exponential increase in the use of molecular dynamics simulations in basic research and industry over the last 5 years, with almost a doubling in the number of publications each year. Many of these are focused on neurological membranes, and biological membranes in general, applied to the medical industry. A smaller portion have utilized membrane simulations to answer more basic questions related to the function of specific proteins, chemicals or biological processes. This review covers some newer studies, alongside studies from the last two decades, to determine changes in the field. Some of these are basic, while others are more profound, such as multi-component embedded membrane machinery. It is clear that many facets of the discipline remain the same, while the focus on and uses of the technology are broadening in scope and utilization as a general research tool. Analysis of recent literature provides an overview of the current methodologies, covers some of the recent trends or advances and tries to make predictions of the overall path membrane molecular dynamics will follow in the coming years. In general, the overview presented is geared towards the general scientific community, who may wish to introduce the use of these methodologies in light of these changes, making molecular dynamic simulations more feasible for general scientific or medical research.

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Section: Analysis Of Membrane Molecular Dynamic Simulationsmentioning

confidence: 99%

Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Watkins

2023

Membranes

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Andrographis Paniculata in the Nanotechnology Era: A Review of Therapeutic Benefits and Novel Formulations

Srinivasan

2024

Int J Pharm Phytopharmacol Res

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Computational and experimental therapeutic efficacy analysis of andrographolide phospholipid complex self-assembled nanoparticles against Neuro2a cells

Cited by 2 publications

References 60 publications

Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Andrographis Paniculata in the Nanotechnology Era: A Review of Therapeutic Benefits and Novel Formulations

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