Compressive Imaging Through Optical Fiber with Partial Speckle Scanning

Guérit, Stéphanie; Sivankutty, Siddharth; Lee, John; Rigneault, Hervé; Jacques, Laurent

doi:10.1137/21m1407586

Cited by 7 publications

(3 citation statements)

References 69 publications

(141 reference statements)

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“…A further generalization of the technique can be made by choosing distal illuminations that are not focal spots, but arbitrary speckle patterns. The mathematical model for this case is described in Appendix F. Speckle illumination is ideal for compressive sampling and can enable imaging with fewer illumination patterns and shorter data acquisition times [31,78]. Furthermore, it can also eliminate the need for wavefront shaping [34].…”

Section: Discussionmentioning

confidence: 99%

“…We can optimize the inversion of the backward TM using a Tikhonov regularization technique [32,60]. This involves computing the singular value decomposition of the backward TM, 𝑇 5"6 " = 𝑈𝑆𝑉 ( and finding its inverse as follows 𝑇 5"6 " 78 = 𝑉𝑆 78 𝑈 ( (6) 𝑆 78 is the regularized inverse of the diagonal matrix of singular values, 𝑆, calculated by replacing the singular values 𝜎 # in the diagonal of S with 9 % 9 % & 0: & , where 𝛽 is the regularization parameter. In experiments, we find that by calculating the backpropagated distal fields using Tikhonov regularized inverse of the 𝑇 5"6 " , instead of F𝑇 5"6 " G ( in equation 6, yields image reconstructions with improved SNR and contrast.…”

Section: Optimal Inversion Of Backward Tmmentioning

confidence: 99%

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Multiview Scattering Scanning Imaging Confocal Microscopy Through a Multimode Fiber

Singh

Labouesse

Piestun

2023

IEEE Trans. Comput. Imaging

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Confocal and multiphoton microscopy are effective techniques to obtain high-contrast images of 2-D sections within bulk tissue. However, scattering limits their application to depths only up to ~1 millimeter. Multimode fibers make excellent ultrathin endoscopes that can penetrate deep inside the tissue with minimal damage. Here, we present Multiview Scattering Scanning Imaging Confocal (MUSSIC) Microscopy that enables high signalto-noise ratio (SNR) imaging through a multimode fiber, hence combining the optical sectioning and resolution gain of confocal microscopy with the minimally invasive penetration capability of multimode fibers. The key advance presented here is the high SNR image reconstruction enabled by employing multiple coplanar virtual pinholes to capture multiple perspectives of the object, reshifting them appropriately and combining them to obtain a highcontrast and high-resolution confocal image. We present the theory for the gain in contrast and resolution in MUSSIC microscopy and validate the concept through experimental results.

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Section: Discussionmentioning

confidence: 99%

Section: Optimal Inversion Of Backward Tmmentioning

confidence: 99%

Multiview Scattering Scanning Imaging Confocal Microscopy Through a Multimode Fiber

Singh

Labouesse

Piestun

2023

IEEE Trans. Comput. Imaging

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“… 54 Compressive sensing improves imaging through multicore fibers by reducing acquisition time, preventing photo-bleaching, and increasing space-bandwidth product. 55 , 56 Compression is also beneficial for conventional raster-scan imaging modalities helping to improve quality by harnessing “muddy” modes 57 and to speed up pre-calibration measurements. 58 …”

Section: Compressive Fiber Imaging: State-of-the-art and Outlookmentioning

confidence: 99%

Multimode fiber endoscopes for computational brain imaging

Amitonova

2024

Neurophoton.

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. Advances in imaging tools have always been a pivotal driver for new discoveries in neuroscience. An ability to visualize neurons and subcellular structures deep within the brain of a freely behaving animal is integral to our understanding of the relationship between neural activity and higher cognitive functions. However, fast high-resolution imaging is limited to sub-surface brain regions and generally requires head fixation of the animal under the microscope. Developing new approaches to address these challenges is critical. The last decades have seen rapid progress in minimally invasive endo-microscopy techniques based on bare optical fibers. A single multimode fiber can be used to penetrate deep into the brain without causing significant damage to the overlying structures and provide high-resolution imaging. Here, we discuss how the full potential of high-speed super-resolution fiber endoscopy can be realized by a holistic approach that combines fiber optics, light shaping, and advanced computational algorithms. The recent progress opens up new avenues for minimally invasive deep brain studies in freely behaving mice.

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Swept-source multimode fiber imaging

Lochocki,

Ivanina,

Bandhoe

et al. 2023

Sci Rep

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High-resolution compressive imaging via a flexible multimode fiber is demonstrated using a swept-laser source and wavelength dependent speckle illumination. An in-house built swept-source allowing for independent control of bandwidth and scanning range is used to explore and demonstrate a mechanically scan-free approach for high-resolution imaging through an ultrathin and flexible fiber probe. The computational image reconstruction is shown by utilizing a narrow sweeping bandwidth of $$< 10$$ < 10 nm while acquisition time is decreased by 95% compared to conventional raster scanning endoscopy. Demonstrated narrow-band illumination in the visible spectrum is vital for the detection of fluorescence biomarkers in neuroimaging applications. The proposed approach yields device simplicity and flexibility for minimally invasive endoscopy.

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Compressive Imaging Through Optical Fiber with Partial Speckle Scanning

Cited by 7 publications

References 69 publications

Multiview Scattering Scanning Imaging Confocal Microscopy Through a Multimode Fiber

Multiview Scattering Scanning Imaging Confocal Microscopy Through a Multimode Fiber

Multimode fiber endoscopes for computational brain imaging

Swept-source multimode fiber imaging

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