Controlling the propagation and interaction of light in complex media has sparked major interest in the last few years. Unfortunately, spatial light modulation devices suffer from limited speed that precludes real-time applications such as imaging in live tissue. To address this critical problem we introduce a phase-control technique to characterize complex media based on the use of fast 1D spatial light modulators and a 1D-to-2D transformation performed by the same medium being analyzed. We implement the concept using a micro-electro-mechanical grating light valve (GLV) with 1088 degrees of freedom modulated at 350 KHz, enabling unprecedented high-speed wavefront measurements. We continuously measure the transmission matrix, calculate the optimal wavefront and project a focus through various dynamic scattering samples in real-time, all within 2.4 ms per cycle. These results improve prior wavefront shaping modulation speed by more than an order of magnitude and open new opportunities for optical processing using 1D-to-2D transformations.

We present an ultra-thin hybrid imaging system based on an optical multimode fiber (MMF) and an optical fiber hydrophone that combines optical resolution photoacoustic and fluorescence microscopy. To control the illumination at the distal tip of the MMF, a digital micromirror device modulates the amplitude of the optical wavefront which is coupled into the MMF. A set of pre-calibrated speckle illuminations combined with a reconstruction algorithm enables photoacoustic and fluorescence imaging of samples located at the distal tip of the fiber with optical resolution determined by the numerical aperture.Here we employ an approach that does not require focus-1 arXiv:1812.11206v1 [physics.optics]

Multimode fibers are attractive for imaging, communication, computation, and energy delivery. Unfortunately, intermodal and polarization coupling precludes direct control of the delivered mode composition. We present a technique to tailor the mode composition at the output of a multimode fiber with thousands of modes, which we refer to as myriad-mode fiber, using its experimentally measured transmission matrix. While precise mode control has been demonstrated in typical multimode fibers with up to 210 modes, the method proposed here is particularly useful for high mode number fibers, such as when the number of modes is comparable to the number of modes of the wavefront shaping spatial light modulator. To illustrate the technique, we select different subsets of modes to create focal spots at the output of a fiber with 7140 modes. Importantly, we define efficiency and fidelity metrics to evaluate the mode control and demonstrate the relationship between efficiency, fidelity, and the spatial location of the spots across the distal fiber cross-section.

Confocal and multiphoton microscopy are effective techniques to obtain high-contrast images of 2-D sections within bulk tissue. However, scattering limits their application to depths only up to ~1 millimeter. Multimode fibers make excellent ultrathin endoscopes that can penetrate deep inside the tissue with minimal damage. Here, we present Multiview Scattering Scanning Imaging Confocal (MUSSIC) Microscopy that enables high signalto-noise ratio (SNR) imaging through a multimode fiber, hence combining the optical sectioning and resolution gain of confocal microscopy with the minimally invasive penetration capability of multimode fibers. The key advance presented here is the high SNR image reconstruction enabled by employing multiple coplanar virtual pinholes to capture multiple perspectives of the object, reshifting them appropriately and combining them to obtain a highcontrast and high-resolution confocal image. We present the theory for the gain in contrast and resolution in MUSSIC microscopy and validate the concept through experimental results.

Confocal and multiphoton microscopy are effective techniques to obtain highcontrast images of 2-D sections within bulk tissue. However, scattering limits their application to depths only up to ~1 millimeter. Multimode fibers make excellent ultrathin endoscopes that can penetrate deep inside the tissue with minimal damage. Here, we present Multiview Scattering Scanning Imaging Confocal (MUSSIC) Microscopy that enables high signal-tonoise ratio (SNR) imaging through a multimode fiber, hence combining the optical sectioning and resolution gain of confocal microscopy with the minimally invasive penetration capability of multimode fibers. The key advance presented here is the high SNR image reconstruction enabled by employing multiple coplanar virtual pinholes to capture multiple perspectives of the object, re-shifting them appropriately and combining them to obtain a high-contrast and highresolution confocal image. We present the theory for the gain in contrast and resolution in MUSSIC microscopy and validate the concept through experimental results.