Compression prediction accuracy from small scale compaction studies to production presses

Pitt, Kendal; Webber, Rachael J.; Hill, Kirsty A.; Dey, Dipankar; Gamlen, Michael

doi:10.1016/j.powtec.2013.10.007

Cited by 46 publications

(39 citation statements)

References 10 publications

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“…The tableting process in the present study was performed by a lab-scale low-speed machine. Pitt et al 50 has shown good agreement between this lab-scale tableting machine (Gamlen GTP-1) and the large-scale industrial press (Fette rotary tablet presses) in some tablet measures including tensile strength and solid fraction for the tablets with different size and shape. In addition, the ejection shear stress data measured on the small-scale Gamlen GTP-1 were able to accurately predict tablet failure on commercial rotary presses for the model dry and wet granulated formulations.…”

Section: Tablet Compactionmentioning

confidence: 77%

“…In addition, the ejection shear stress data measured on the small-scale Gamlen GTP-1 were able to accurately predict tablet failure on commercial rotary presses for the model dry and wet granulated formulations. 50 Because tableting speed could have potential impact on the quality of the formed tablets (i.e., lamination or capping 51 ), future studies are warranted to test the feasibility to tablet the developed formulations in a high-speed manufacturing-scale setup.…”

Section: Tablet Compactionmentioning

confidence: 99%

See 1 more Smart Citation

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Stewart

Hapgood

et al. 2017

Journal of Pharmaceutical Sciences

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Section: Tablet Compactionmentioning

confidence: 77%

Section: Tablet Compactionmentioning

confidence: 99%

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Stewart

Hapgood

et al. 2017

Journal of Pharmaceutical Sciences

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“…Tensile strength provides information about the crushing strength of the tablet. Tablets with tensile strengths above 2.0 MPa are typically thought to be strong enough to withstand typical packaging and coating operations [15,17]. However, it has been shown that tablets with a tensile strength as low as 1…”

Section: Esh996294 Phoenix Materials Testingmentioning

confidence: 99%

Co-Processed Excipients for Dispersible Tablets–Part 1: Manufacturability

et al. 2018

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Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterise a range of co-processed excipients that may prove suitable for dispersible tablet formulations prepared by direct compression. Co-processed excipients were lubricated and compressed into 10.5-mm convex tablets using a Phoenix compaction simulator. Compression profiles were generated by varying the compression force applied to the formulation and the prepared tablets were characterised for hardness, friability, disintegration and fineness of dispersion. Our data indicates that CombiLac, F-Melt type C and SmartEx QD100 were the top 3 most suitable out of 16 co-processed excipients under the conditions evaluated. They exhibited good flow properties (Carr's index ˂ 20), excellent tabletability (tensile strength > 3.0 MPa at 0.85 solid fraction), very low friability (< 1% after 15 min), rapid disintegration times (27-49 s) and produced dispersions of ideal fineness (< 250 μm). Other co-processed excipients (including F-Melt type M, Ludiflash, MicroceLac, Pharmaburst 500 and Avicel HFE-102) may be appropriate for dispersible tablets produced by direct compression providing the identified disintegration and dispersion risks were mitigated prior to commercialisation. This indicates that robust dispersible tablets which disintegrate rapidly could be manufactured from a range of co-processed excipients.

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“…Figure 6A and B represents the ejection shear stress and detachment force plots respectively. Ejection shear stress is the stress generated during the tablet ejection process and it is represented by a plot of ejection shear stress against compaction pressure (Gamlen, 2017;Pitt et al, 2015). The plot shows an increase in ejection shear stress as the compaction pressure increases for all three materials.…”

Section: Fig 5 Ctc Plots For Sas-cd Sas-cf and Sas-cg (A) Compresmentioning

confidence: 99%

“…SAS-CD and SAS-CF had lower ejection shear stress and detachment force suggesting a greater degree of selflubricating potential. Ejection shear stress > 5 MPa has been associated with manufacturing problems like capping and lamination (Gamlen, 2017;Pitt et al, 2015). To avoid the occurrence of tableting defects with the use of these materials in tableting, it will be necessary to properly lubricate formulations containing these materials.…”

Section: Fig 6 (A) Ejection and (B) Detachment Plots For Sas-cd Samentioning

confidence: 99%

Comparative analysis of co-processed starches prepared by three different methods

Apeji¹,

Aluga²,

Olayemi³

et al. 2017

British Journal of Pharmacy

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Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that cogranulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of coprocessing influences the powder and tableting properties of the co-processed excipient.

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Compression prediction accuracy from small scale compaction studies to production presses

Cited by 46 publications

References 10 publications

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression

Co-Processed Excipients for Dispersible Tablets–Part 1: Manufacturability

Comparative analysis of co-processed starches prepared by three different methods

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