Comprehensive two‐dimensional gas chromatography (GC×GC) and GC×GC‐quadrupole MS analysis of Asian and American ginseng

Shellie, Robert A.; Marriott, Philip J.; Huie, Carmen W.

doi:10.1002/jssc.200301404

Cited by 83 publications

(56 citation statements)

References 23 publications

(19 reference statements)

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“…In 2003, the use of qMS systems, operated under relatively fast-scanning conditions, was reported in a series of GC Â GC experiments (Shellie & Marriott, 2003a;Shellie, Marriott, & Huie, 2003b;Kallio et al, 2003). The main advantage of such systems over ToF-MS instrumentation appeared to be the much lower costs.…”

Section: The Turning-point Year: 2003mentioning

confidence: 99%

“…The main advantage of such systems over ToF-MS instrumentation appeared to be the much lower costs. In particular, Shellie, Marriott, and Huie (2003b) applied GC Â GC-qMS to the analysis of ginseng volatiles. The use of a rapid scanning system (5973 mass selective detector, Agilent) enabled the application of common GC Â GC operating conditions.…”

Section: The Turning-point Year: 2003mentioning

confidence: 99%

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Comprehensive two‐dimensional gas chromatography‐mass spectrometry: A review

Mondello

Tranchida

Dugo

et al. 2008

Mass Spectrometry Reviews

379

224

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Although comprehensive two-dimensional gas chromatography (GC Â GC) has been on the scene for more than 15 years, it is still generally considered a relatively novel technique and is yet far from being fully established. The revolutionary aspect of GC Â GC, with respect to classical multidimensional chromatography, is that the entire sample is subjected to two distinct analytical separations. The resulting enhanced separating capacity makes this approach a prime choice when GC analysts are challenged with highly complex mixtures. The combination of a third mass spectrometric dimension to a GC Â GC system generates the most powerful analytical tool today for volatile and semi-volatile analytes. The present review is focused on the rather brief, but not scant, history of comprehensive two-dimensional GC-MS: the first experiments were carried out at the end of the 1990s and, since then, the methodology has been increasingly studied and applied. Almost all GC Â GC-MS applications have been carried out by using either a time-of-flight or quadrupole mass analyzer; significant experiments relative to a variety of research fields, as well as advantages and disadvantages of the MS systems employed, are discussed. The principles, practical and theoretical aspects, and the most significant developments of GC Â GC are also described. #

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Section: The Turning-point Year: 2003mentioning

confidence: 99%

Section: The Turning-point Year: 2003mentioning

confidence: 99%

Comprehensive two‐dimensional gas chromatography‐mass spectrometry: A review

Mondello

Tranchida

Dugo

et al. 2008

Mass Spectrometry Reviews

379

224

View full text Add to dashboard Cite

show abstract

“…This still gives peaks broader than those in the FID, but also compromises sensitivity due to a dilution effect. Scan speed limitations are also recognised for GC6GC-qMS, resulting in a reduced number of data points than normally required for peak quantitation; however, identification provided by qMS has proved valuable [4]. Thus, it is apparent that each detector used for GC6GC must be critically evaluated with respect to operational considerations that may limit or affect performance.…”

Section: Introductionmentioning

confidence: 99%

Studies on thermionic ionisation detection in comprehensive two‐dimensional gas chromatography

Ryan

Marriott²

2006

J of Separation Science

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Original Paper Studies on thermionic ionisation detection in comprehensive two-dimensional gas chromatographyThis study explores the application of specific thermionic ionisation detection in comprehensive 2-D GC (GC6GC) and represents the first report of GC6GC with nitrogen phosphorus detection (GC6GC-NPD). Of particular interest is the performance of the NPD with respect to peak parameters of asymmetry and sensitivity. Since GC6GC produces much narrower peaks than obtained with fast GC (e. g. 100 ms vs. a 1 s) the effect of detector response time and any lack of symmetry arising from the detection step is important if peak separation (resolution) is to be maintained. It was observed that detector gas flows had a significant impact on peak asymmetry and peak magnitude, and that optimisation of the detector was critical, particularly for complex sample analysis by GC6GC-NPD. Peak asymmetries ranging from A s = 1.8 to 8.0 were observed under different conditions of detector gas flows. Comparison of GC6GC-NPD with GC6GC-flame ionisation detection (FID) showed the former to be approximately 20 times more sensitive for the detection of nitrogen-containing methoxypyrazines analytes, and GC6GC-NPD had a larger linear detection range compared to GC6GC-FID. Furthermore, comparison of GC6GC-NPD and GC6GC-TOFMS chromatograms for the analysis of coffee headspace demonstrated the benefits of selective detection, ultimately realised in a comparatively simplified contour plot.

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“…Several authors tried to push the performance of qMS devices by playing with the mass range; for example, Shellie et al (2003) attained 20 scan/s using a 4000 m/z per second qMS scan speed and by reducing the mass range, in ginseng applications. Cordero et al (2007) used a qMS system with a high scan speed (11,111 m/z per second) in allergen analysis; however, it was found necessary to reduce the mass range (40e240 m/z) to achieve 18.52 scan/s because of the rather high interscan delay (30 ms).…”

Section: Instrumentation and Fundamental Operational Parameters 417mentioning

confidence: 99%