Comprehensive Surgical Strategies for the Management of Pachydermoperiostosis

Abstract

The cosmetic and functional deformities induced by thickened folds and furrows are the main complaints of patients in pachydermoperiostosis (PDP). However, traditional drug therapy only has a limited effect for its unclear genetic pathogenesis. Surgical treatment has now become one of the optimal strategies mainly aiming for its cosmetic improvement. Here we describe a comprehensive management of PDP approached with surgical procedure thereby showing markedly improved cosmetic outcome. Experientially, the surgical treatment of PDP is effective and may be preferentially recommended for PDP patients especially of severe degree.

Chronic Enteropathy Associated with SLCO2A1-Associated Primary Hypertrophic Osteoarthropathy in Female Patients: A Case Report and Literature Review

“…Balloon expansion under colonoscopy is the method used to treat this complication [14]. There is also currently no effective cure for PHO, and drugs are mainly used to relieve symptoms and plastic surgery is applied to improve the facial skin thickening for cosmetic purposes [22,33]. Drug treatments mainly use nonsteroidal anti-in ammatory drugs (NSAIDs) that reduce prostaglandin synthesis.…”

Frontal lifting using a tissue expander in pachydermoperiostosis: A case report

“…Pachydermoperiostosis predominantly occurs in male individuals at a ratio of 9:1, with a familial inheritance pattern, and both autosomal dominant inheritance and autosomal recessive inheritance have been described 4,6 . Various treatments, such as rhytidoplasty, rhytidectomy, and botulinum toxin injections, have been described in the literature 7‐9 . Two cases involving frontal region treatment associated with the use of tissue expanders prior to frontal rhytidoplasty have also been reported 9,10 …”

“…[7][8][9] Two cases involving frontal region treatment associated with the use of tissue expanders prior to frontal rhytidoplasty have also been reported. 9,10 A search was performed of the PubMed and Embase databases using the following terminology: pachydermoperiostosis, "Touraine Solente and Golé Syndrome," treatment, surgical treatment, frontal lifting, subperiosteal lifting, tissue expander, and combinations of these. We aimed to report an unusual surgical treatment, the third case in the literature to the best of our knowledge, involving the frontal region in a patient with pachydermoperiostosis using a tissue expander before rhytidoplasty to thin the skin and decrease the prominent wrinkles and folds that are characteristic of the disease.…”

“…4,6 Various treatments, such as rhytidoplasty, rhytidectomy, and botulinum toxin injections, have been described in the literature. [7][8][9] Two cases involving frontal region treatment associated with the use of tissue expanders prior to frontal rhytidoplasty have also been reported. 9,10 A search was performed of the PubMed and Embase databases using the following terminology: pachydermoperiostosis, "Touraine Solente and Golé Syndrome," treatment, surgical treatment, frontal lifting, subperiosteal lifting, tissue expander, and combinations of these.…”

Pachydermoperiostosis Associated with Myelofibrosis: A Rare Case Report

“…Other surgical techniques have been used such as frontal rhytidoplasty and facelift, which is recommended based on the specific circumstances of different individuals. [10] Botulinum toxin can bring temporary results.…”