Febrile seizures (FS) occur in 2% to 5% of all children and are most common convulsive event in children younger than 60 month. Recurrence of FS ranges from 21-43% in different studies and are associated with various risk factors like age of onset of 1 st episode of FS less than 1 year, duration and grade of fever, parental consanguinity, family history of FS and epilepsy, male gender and complex FS as initial seizure. AIMS AND OBJECTIVE: The purpose of this study was to evaluate the risk factors and their association for recurrences of febrile seizures in children aged between 6 months to 5 years of age.
MATERIALS & METHODS:The study design was prospective observational study in which 63 children (6 months to 5 years) presenting with the first episode of FS to Dr. Punjabrao Deshmukh Medical College, Amravati between 1 st November 2013 to 31 st October 2014 were enrolled in the study. These subjects were followed up for a period of 1 year from the date of 1 st episode of FS. RESULTS: In present study 46 out of 63 subjects had recurrence of FS. Male: female ratio in the recurrence group was 0.76:1. Family history of FS and epilepsy was present in 34.9% and 12.6% respectively. Total 67.34% subjects with simple FS and 92.85% with complex FS had recurrence. 69.69% subjects had FS within 24 hours of onset of fever. Parental consanguinity was found in 14 (22.2%) subjects with p value of 0.013. No association between the number of risk factors and recurrence was found. 22 (34.9%) out of total 63 subjects were on intermittent FS prophylaxis during the febrile illness and 15 subjects still had recurrence of FS and hence no significant association between recurrence of FS and intermittent prophylaxis for FS was seen. CONCLUSION: Parental consanguinity and age less than one year for 1 st episode of FS were the only significant risk factors indentified for the recurrence of FS. Age of onset of 1 st episode of FS less than 1 year, duration of fever, grade of fever, family history of FS and epilepsy, male gender and complex febrile seizure as initial seizure were not found to be significantly associated with recurrence of FS. No significant association between the numbers of risk factors and recurrence of FS was found. Prescribing prophylaxis for FS statistically did not show any benefit in decreasing the frequency nor completely stop the recurrences of FS.