Comprehensive Registry of Esophageal Cancer in Japan, 2002

Ozawa, Soji; Tachimori, Yuji; Baba, Hideo; Matsubara, Hisahiro; Muro, Kei; Numasaki, Hodaka; Oyama, Tsuneo; Sekiguchi, Masayuki; Takeuchi, Hiroya; Tanaka, Otsuo; Teshima, Teruki; Udagawa, Harushi; Umemura, Takashi; Barron, J. Patrick

doi:10.1007/s10388-010-0228-6

Cited by 47 publications

(26 citation statements)

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“…Although adenocarcinoma is the most prevalent subtype (>50%) of esophageal cancer in the USA (9), >90% of esophageal cancer cases are ESCC in Japan (10,11). Thus, in the present study we investigated whether Girdin is also involved in the motility of ESCC cells.…”

Section: Introductionmentioning

confidence: 97%

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

et al. 2013

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Abstract. Girdin, an actin-binding Akt substrate, regulates actin reconstruction and Akt-dependent cell motility in fibroblasts and in a human breast cancer cell line. We examined whether Girdin is also involved in the motility of esophageal squamous cell carcinoma (ESCC) cells. Immunofluorescent staining and migration assays were performed, using KYSE cell lines, to examine whether Girdin is involved in the motility of ESCC cells. Upon EGF stimulation, Girdin colocalized with filamentous actin (F-actin) in the lamellipodia as determined by immunofluorescent staining. In migration assays, cell motility was significantly reduced in KYSE cell lines transfected with Girdin siRNA compared with the negative control. In addition, we examined the relationship between Girdin expression and clinical data, using specimens resected from ESCC patients. In immunohistochemical (IHC) analyses using specimens resected from ESCC patients, overall survival was significantly longer in cases showing lower Girdin expression compared to cases with higher Girdin expression. Collectively, Girdin appears to be involved in the motility of ESCC cells. The levels of Girdin expression correlated inversely with the survival of ESCC patients. Therefore, in ESCC, Girdin may be a prognostic marker and may serve as a therapeutic target as well.

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Section: Introductionmentioning

confidence: 97%

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

et al. 2013

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“…A nationwide registry of 5066 Japanese patients with esophageal cancer treated in 2004 showed that second cancers in another organ were present in 981 patients (19.4%). Gastric cancer was the most common form of cancer (353 lesions), followed by H&N cancer, including 162 pharyngeal cancers, 66 laryngeal cancers and 24 cancers in the oral cavity (17). We previously reported that both heavy smoking and heavy drinking are well-established risk factors for HNC and ESCC, and for multiple occurrences of cancer in these areas (2,18,19); the current study revealed the synchronous combination of superficial ESCC and advanced HNC are most frequently recognized.…”

Section: Discussionmentioning

confidence: 93%

Treatment of Squamous Cell Carcinoma of the Esophagus Synchronously Associated with Head and Neck Cancer

Morita

Egashira

Nakaji

et al. 2018

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Abstract. Background/Aim: The aim of this study was to clarify the treatment strategy for synchronous squamous cell carcinoma of the esophagus (ESCC) and head and neck cancer (HNC). Patients and MethodsThe multifocal development of squamous cell carcinoma (SCC) is frequently observed in the upper aerodigestive tract (UADT) including the head and neck region and the esophagus. The association of these cancers is observed both synchronously and metachronously (1). These cancers are highly aggressive and until relatively recently were usually associated with a dismal prognosis. Environmental factors such as cigarette smoking and alcohol drinking are closely related to the development of SCC of the UADT. Furthermore, we have reported that both heavy smoking and heavy drinking have synergistic effects on multi-centric carcinogenesis of the UADT (1, 2).Regarding the treatment strategy, surgical resection has been the gold standard of treatment for localized UADT cancer. However, this surgery is extremely invasive and is also associated with high rates of mortality and morbidity, especially in patients with esophageal cancer and pharyngeal cancer (3, 4). Patients with synchronous squamous cell carcinoma of the esophagus (ESCC) and head and neck cancer (HNC) often require for extremely complex and invasive surgical procedures in order to resect both lesions (5-7). The surgical procedures for synchronous double cancer therefore represent an important clinical problem.On the other hand, squamous cell carcinoma of the UADT is relatively sensitive to radiation and anticancer drugs such as 5-fluorouracil, cisplatin and paclitaxel (8-10). Definitive chemoradiotherapy is frequently indicated for ESCC while invasive esophagectomy is normally avoided (11). For patients with HNC, the preservation of the vocal function can be achieved if HNC is cured after definitive chemoradiotherapy (CRT). Definitive CRT for synchronous ESCC and HNC is controversial due to the larger radiation field and associated toxicity (12). In our institute, simultaneous definitive CRT has been applied in the treatment of synchronous ESCC and HNC (13,14). Another problem is that salvage treatment, which is frequently troublesome, may be indicated in cases with either residual or recurrent cancer after definitive CRT (4,11).In this study, we reviewed the clinical characteristics and treatment outcomes in 91 patients with synchronous ESCC and HNC, and paid special attention to simultaneous surgical resection and simultaneous CRT for both cancers. 909

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“…, Naohiko Koide 1) , Akira Suzuki 1) , Daisuke Takeuchi Department of Clinical Laboratory Medicine, Shinshu University Hospital A 64 year-old woman complained of dysphagia. Esophagogastroduodenoscopy showed an elevated tumor (type-1) in the middle thoracic esophagus, and biopsy specimens taken from the tumor histopathologically revealed neuroendocrine carcinoma and carcinosarcoma.…”

Section: ．本例では，術後の病理組織学的検査所見では病変のmentioning

confidence: 99%

A Case of Neuroendocrine Carcinoma with Sarcomatous, Squamous, and Glandular Components of the Esophagus

康広¹,

直彦²,

彰³

et al. 2013

Jpn J Gastroenterol Surg

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Comprehensive Registry of Esophageal Cancer in Japan, 2002

Cited by 47 publications

References 0 publications

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

Treatment of Squamous Cell Carcinoma of the Esophagus Synchronously Associated with Head and Neck Cancer

A Case of Neuroendocrine Carcinoma with Sarcomatous, Squamous, and Glandular Components of the Esophagus

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