Comprehensive profiling of α-glucosidase inhibitors from the leaves of Rubus suavissimus using an off-line hyphenation of HSCCC, ultrafiltration HPLC-UV-MS and prep-HPLC

Liu, Minzhuo; Li, Xujie; Liu, Qi; Xie, Siqi; Chen, Miao; Wang, Lumin; Yan, Feng; Chen, Xiaoqing

doi:10.1016/j.jfca.2019.103336

Cited by 21 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that the concentrations of ellagic acid, rutin, and gallic acid in 14 Chinese sweet tea samples collected in different seasons ranged from 0.46% to 92%, 0.08% to 0.15%, and 0.1% to 0.16%, respectively [ 2 ]. More recently, Liu et al [ 5 ] reported 14 new phenolic compounds in Chinese sweet tea leaves. In our study, seven new phenolic compounds were identified for the first time in Chinese sweet tea namely, p -coumaric acid, benzoic acid, o -coumaric acid, resveratrol, neringein, rosmarinic, and myricetin.…”

Section: Resultsmentioning

confidence: 99%

“…Chinese sweet tea is generally used in folk medicine for a wide range of diseases—i.e., coughs, diabetes, and atherosclerosis (high blood pressure)—as well as to promote kidney function. Moreover, different biological activities of Chinese sweet tea—i.e., antioxidant, anti-allergic, anti-inflammatory, anticancer activity, antiangiogenic, antidiabetic, and anti-obesity activities—have been reported [ 3 , 4 , 5 , 6 ]. These biological activities are linked to the presence of various bioactive components in Chinese sweet tea, including gallic acid, ellagic acid, rutin, kaempferol, caffeic acid, quercetin, rubusoside, and steviol monoside [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…These biological activities are linked to the presence of various bioactive components in Chinese sweet tea, including gallic acid, ellagic acid, rutin, kaempferol, caffeic acid, quercetin, rubusoside, and steviol monoside [ 3 ]. Recently, 14 new phenolic compounds in Rubus suavissimus S. Lee, including protocatechuic acid, myketin, epicatechin, vanillic acid, apigenin, catechin, ferulic acid, luteolin, 3, 3′-di-O-methylellagic acid, chlorogenic acid, 3, 3′-di-O-methylellagic acid-4′-O-β-D-glucoside, cinnamic acid, and syringate, have been identified [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of a Multifunction Set Yogurt Using Rubus suavissimus S. Lee (Chinese Sweet Tea) Extract

Abdel-Hamid

Huang

Suzuki

et al. 2020

Foods

View full text Add to dashboard Cite

Rubus suavissimus S. Lee leaves, also known as Chinese sweet tea or Tiancha, are used in folk medicine in southern China. This study evaluated the impact of the addition of Chinese sweet tea extract (0.25%, 0.5%, and 1%) on the chemical composition, organoleptic properties, yogurt culture viability, and biological activities (i.e., antioxidant, anticancer, and antihypertensive activities) of yogurt. Seven phenolic compounds were reported in Chinese sweet tea for the first time. The numbers of the yogurt culture were similar across all yogurt treatments. The yogurt supernatant with 0.25%, 0.5%, and 1% Chinese sweet tea extract had a total phenolic content that was 3.6-, 6.1-, and 11.2-fold higher, respectively, than that of the control yogurt. The biological activities were significantly increased by the addition of Chinese sweet tea extract: Yogurt with the addition of 1% Chinese sweet tea extract had the highest biological activities in terms of the antioxidant activity (92.43%), antihypertensive activity (82.03%), and inhibition of the Caco-2 cell line (67.46%). Yogurt with the addition of 0.5% Chinese sweet tea extract received the highest aroma and overall acceptability scores. Overall, Chinese sweet tea extract is a promising food ingredient for producing functional yogurt products that may substantially contribute to reducing the risk of developing chronic diseases such as cancer and cardiovascular disease.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of a Multifunction Set Yogurt Using Rubus suavissimus S. Lee (Chinese Sweet Tea) Extract

Abdel-Hamid

Huang

Suzuki

et al. 2020

Foods

View full text Add to dashboard Cite

show abstract

“…Separation and purification methods including column chromatography and solvent floatation sublation [14][15][16] have been used, but these methods are long time consumption, wasting large amounts of solvents, and irreversible adsorption. As a liquid-liquid partition chromatography, high-speed countercurrent chromatography (HSCCC) has obvious advantages compared with other chromatographic methods [17][18][19][20][21]. HSCCC can achieve multi-target purification without irreversible adsorption from complex mixtures with high recovery [22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Isolation and purification of flavonoids from Euonymus alatus by high‐speed countercurrent chromatography and neuroprotective effect of rhamnazin‐3‐O‐rutinoside in vitro

Liu

Che

et al. 2021

J of Separation Science

View full text Add to dashboard Cite

The flavonoids from Euonymus alatus exhibit many biological activities including significant antioxidant, anti-inflammatory, anti-cancer. In this work, a highspeed countercurrent chromatography method for the isolation and purification of flavonoids from crude extracts of Euonymus alatus was established. The effects of several solvent systems on the separation efficiency of target compounds in the extract of Euonymus alatus were studied. The solvent system composed of nhexane-ethyl acetate-methanol-water at a volume ratio of (3:5:3:5, v/v) was chosen, in which the lower phase was used as the mobile phase at the rotation speed of 800 rpm and flow rate of 2.0 mL/min. The three flavonoids were obtained and identified as patuletin-3-O-rutinoside, rhamnazin-3-O-rutinoside, and dehydrodicatechin A by mass spectroscopy and nuclear magnetic resonance, and the quantities of patuletin-3-O-rutinoside, rhamnazin-3-O-rutinoside, and dehydrodicatechin A were 2.2, 9.7, and 1.8 mg, respectively. The results indicated that high-speed countercurrent chromatography was a simple and efficient method for the isolation and purification of flavonoids from the crude extracts of Euonymus alatus. The cellular antioxidant activity experimental result indicated that rhamnazin-3-O-rutinoside could alleviate H 2 O 2 -induced oxidative stress.

show abstract

“…Rubusoside is a natural non-caloric sweetener and mainly extracted from Rubus suavissimus S. Lee which only grows in the southern area of China ( Ko et al, 2012 ). It is approximately 114 times sweeter than sucrose ( Darise et al, 1984 ) and displays diverse bioactivities, such as hypoglycemic, antiallergic, anticariogenic, and antiangiogenic functions ( Liu et al, 2006 , 2020 ; Kim et al, 2019 ; Wang et al, 2020 ). Therefore, rubusoside has been widely used as an additive to herbal tea and healthy beverages.…”

Section: Introductionmentioning

confidence: 99%

A Novel β-Glucosidase From Chryseobacterium scophthalmum 1433 for Efficient Rubusoside Production From Stevioside

et al. 2021

View full text Add to dashboard Cite

Graphical AbstractAs a natural sweetening and solubilizing agent, rubusoside has great potential in the application of healthy beverages and pharmaceuticals. A novel β-glucosidase CsBGL obtained here from Chryseobacterium scophthalmum 1433 through screening of the environmental microorganisms could specifically hydrolyze the C-13- or/and C-19-linked sophorese of steviol glycosides, but not the C-13- or/and C-19-linked Glcβ1-2[Glcβ1-3]Glc trisaccharide and Glcβ1-monosaccharide of steviol glycosides, and thus could be a promising biocatalyst for efficient rubusoside production from stevioside.

show abstract

Comprehensive profiling of α-glucosidase inhibitors from the leaves of Rubus suavissimus using an off-line hyphenation of HSCCC, ultrafiltration HPLC-UV-MS and prep-HPLC

Cited by 21 publications

References 29 publications

Development of a Multifunction Set Yogurt Using Rubus suavissimus S. Lee (Chinese Sweet Tea) Extract

Development of a Multifunction Set Yogurt Using Rubus suavissimus S. Lee (Chinese Sweet Tea) Extract

Isolation and purification of flavonoids from Euonymus alatus by high‐speed countercurrent chromatography and neuroprotective effect of rhamnazin‐3‐O‐rutinoside in vitro

A Novel β-Glucosidase From Chryseobacterium scophthalmum 1433 for Efficient Rubusoside Production From Stevioside

Contact Info

Product

Resources

About