Comprehensive Landscape of Prognostic Significance and Immune Characteristics of Myosins in Squamous Cell Carcinoma of the Head and Neck

Zhu, Yuying; Zheng, Shikang; Zhai, Xingyou; Wang, Cheng; Liu, Aijun; Ju, Jun; Xin, Peng; Chen, Liwei; Zhang, Yongxia; Ren, Nan; Xie, Yingli; Fan, Junda; Zhao, Kai; Liu, Mingbo

doi:10.1155/2022/5501476

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…For instance, MYO1B in HNC promoted tumor development by mediating the process of EMT. 42 Hence, the knockdown of MYO1B attenuated the migration and invasion abilities of HNC cells, and thus significantly inhibited LNM. 43 In colon cancer, upregulation of MYO1B promoted tumor metastasis by mediating the RhoA/ ROCK/FAK signaling pathway, resulting in poor prognosis in patients.…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies have shown that MYO1B is aberrantly expressed in a variety of tumors and is closely associated with tumorigenesis, progression, and prognosis determination. For instance, MYO1B in HNC promoted tumor development by mediating the process of EMT 42 . Hence, the knockdown of MYO1B attenuated the migration and invasion abilities of HNC cells, and thus significantly inhibited LNM 43 .…”

Section: Discussionmentioning

confidence: 98%

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MYO1B as a prognostic biomarker and a therapeutic target in Arecoline‐associated oral carcinoma

Sun

Guo

Chen

et al. 2023

Molecular Carcinogenesis

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Background Arecoline, the main component of betel nut, induces malignant transformation of oral cells through complicated unclear mechanisms. Thus, we aimed to screen the key genes involved in Arecoline‐induced oral cancer and further verify their expressions and roles. Methods This study included a data‐mining part, a bioinformatics verification part, and an experimental verification one. First, the key gene related to oral cancer induced by Arecoline was screened. Then, the expression and clinical significance of the key gene in head and neck/oral cancer tissues were verified, and its downstream mechanisms of action were explored. Afterwards, the expression and roles of the key gene were verified by experiments at the histological and cytological levels. Results MYO1B was identified as the key gene. Overexpression of MYO1B was associated with lymph node metastasis and unfavorable outcomes in oral cancer. MYO1B may be mainly related to metastasis, angiogenesis, hypoxia, and differentiation. A positive correlation between MYO1B and the infiltration of macrophages, B cells, and dendritic cells was presented. MYO1B might have a close relationship with SMAD3, which may be enriched in the Wnt signaling pathway. MYO1B suppression markedly inhibited the proliferation, invasion, and metastasis abilities of both Arecoline‐transformed oral cells and oral cancer cells. Conclusion This study revealed MYO1B as a key gene in Arecoline‐induced oral tumorigenesis. MYO1B might be a novel prognostic indicator and therapeutic target for oral cancer.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

MYO1B as a prognostic biomarker and a therapeutic target in Arecoline‐associated oral carcinoma

Sun

Guo

Chen

et al. 2023

Molecular Carcinogenesis

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“…It is proposed that MYO1B may facilitated the propagation and metastasis of HNSC through the EMT process. Meanwhile, it has been recently reported that silencing of MYO1B alleviated the EMT potential of HNSC 49 .…”

Section: Discussionmentioning

confidence: 99%

CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma

Li¹,

Qiu²,

He³

et al. 2023

Sci Rep

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Head and neck squamous cell carcinoma (HNSC) is one of the leading causes of cancer death globally, yet there are few useful biomarkers for early identification and prognostic prediction. Previous studies have confirmed that CCND1 amplification is closely associated with head and neck oncogenesis, and the present study explored the ceRNA network associated with CCND1. Gene expression profiling of the Head and Neck Squamous Cell Carcinoma (HNSC) project of The Cancer Genome Atlas (TCGA) program identified the TPRG1-AS1-hsa-miR-363-3P-MYO1B gene regulatory axis associated with CCND1. Further analysis of the database showed that MYOB was regulated by methylation in head and neck tumors, and functional enrichment analysis showed that MYO1B was involved in "actin filament organization" and "cadherin binding ". Immune infiltration analysis suggested that MYO1B may influence tumorigenesis and prognosis by regulating the immune microenvironment of HNSC. MYO1B enhanced tumor spread through the EMT approach, according to epithelial mesenchymal transition (EMT) characterisation. We analyzed both herbal and GSCALite databases and found that CCND1 and MYO1B have the potential as predictive biomarkers for the treatment of HNSC patients. RT-qPCR validated bioinformatic predictions of gene expression in vitro cell lines. In conclusion, we found a CCND1-related ceRNA network and identified the novel TPRG1-AS1-hsa-miR-363-3p-MYO1B pathway as a possible HNSC diagnostic biomarker and therapeutic target.

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m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways

Zhao,

Chen,

Xie

et al. 2024

Cancer Letters

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Comprehensive Landscape of Prognostic Significance and Immune Characteristics of Myosins in Squamous Cell Carcinoma of the Head and Neck

Cited by 3 publications

References 43 publications

MYO1B as a prognostic biomarker and a therapeutic target in Arecoline‐associated oral carcinoma

MYO1B as a prognostic biomarker and a therapeutic target in Arecoline‐associated oral carcinoma

CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma

m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways

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