Comprehensive interpretation of hyperglycemia and hyperosmolality on the clinical outcomes among ischemic stroke patients

Ock, Seunghun; Jo, Sion; Lee, Jae Baek; Jin, Young Ho; Jeong, Tak; Yoon, Jae Chol; Park, Boyoung

doi:10.1016/j.ajem.2016.08.046

Cited by 6 publications

(3 citation statements)

References 55 publications

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“…Most patients with dehydration in this study had blood hyperviscosity (95.2%). This finding corresponds with studies stated that dehydration could increase blood viscosity [34][35][36].…”

Section: Discussionsupporting

confidence: 92%

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Blood Viscosity as a Determining Factor of Ischemic Stroke Outcomes Evaluated With Nihss and MRS on Day 7 and 30 Post-Thrombolysis

Rasyid

Harris

Kurniawan

et al. 2019

Int J Pharm Pharm Sci

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Objective: This study aimed to analyze blood viscosity as a determining factor of ischemic stroke outcomes evaluated with National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) on day 7 and 30 post-thrombolysis. Methods:This study was a 4-months cohort study taking place in Cipto Mangunkusumo General Hospital from January to April 2017. Subjects were collected at the Emergency Department or Neurology Outpatient Department. Eligible patients gave informed consent. Patients underwent numerous examinations, including blood viscosity test using digital microcapillary (DM) instrument. Outcomes of patients were identified on day 7 and day 30 post-thrombolysis using NIHSS and mRS, respectively. Results:Most acute ischemic stroke patients (88.6%) had blood hyperviscosity. 9.1% patients had poorer neurologic deficit on day 7 evaluated with NIHSS and 18.2% patients had poor outcome on day 30 evaluated with mRS. All patients with normal blood viscosity did not have a poorer neurologic deficit on day-7-evaluation.Conclusion: Blood viscosity determines the outcomes of acute ischemic stroke patients on day 7 and day 30 post-thrombolysis.

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“…Most patients with dehydration in this study had blood hyperviscosity (95.2%). This finding corresponds with studies stated that dehydration could increase blood viscosity [34][35][36].…”

Section: Discussionsupporting

confidence: 92%

“…[33]. Dehydration can reduce cerebral blood flow (CBF) and cerebral perfusion pressure (CPP) thus worsen ongoing ischemia and eventually lead to worse outcomes [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Blood Viscosity as a Determining Factor of Ischemic Stroke Outcomes Evaluated With Nihss and MRS on Day 7 and 30 Post-Thrombolysis

Rasyid

Harris

Kurniawan

et al. 2019

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

“…However, the association did not reach significance. As in another study, Ock and his colleagues 34 explored the effects of hyperglycemia and hyperosmolality on clinical outcomes among ischemic stroke patients. They also failed to find an association for hyperosmolality (with or without hyperglycemia) or hyperglycemia alone with death either at discharge or at 6 months after stroke onset.…”

Section: Discussionmentioning

confidence: 93%

Association between Plasma Osmolality and Case Fatality within 1 Year after Severe Acute Ischemic Stroke

et al. 2021

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Purpose Plasma osmolality, a marker of dehydration, is associated with cardiovascular mortality. We aimed to investigate whether elevated plasma osmolality is associated with case fatality within 1 year after severe acute ischemic stroke. Materials and Methods We included severe ischemic stroke patients (defined as National Institutes of Health Stroke Scale ≥15 score) within 24 hours from symptom onset admitted to the Department of Neurology, West China Hospital between January 2017 and June 2019. Admission plasma osmolality was calculated using the equation 1.86*(sodium+potassium)+1.15*glucose+urea+14. Elevated plasma osmolality was defined as plasma osmolality >296 mOsm/kg, indicating a state of dehydration. Study outcomes included 3-month and 1-year case fatalities. Multivariable logistic regression was performed to determine independent associations between plasma osmolality and case fatalities at different time points. Results A total of 265 patients with severe acute ischemic stroke were included. The mean age was 71.2±13.1 years, with 51.3% being males. Among the included patients, case fatalities were recorded for 31.7% (84/265) at 3 months and 39.6% (105/265) at 1 year. Elevated plasma osmolality (dehydration) was associated with 3-month case fatality [odds ratio (OR) 1.98, 95% confidence interval (CI) 1.07–3.66, p =0.029], but not 1-year case fatality (OR 1.51, 95% CI 0.84–2.72, p =0.165), after full adjustment for confounding factors. Conclusion Elevated plasma osmolality was independently associated with 3-month case fatality, but not 1-year case fatality, for severe acute ischemic stroke.

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Conivaptan and Boric Acid Treatments in Acute Kidney Injury: Is This Combination Effective and Safe?

Can

Kar²,

Kar

et al. 2021

Biol Trace Elem Res

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Comprehensive interpretation of hyperglycemia and hyperosmolality on the clinical outcomes among ischemic stroke patients

Cited by 6 publications

References 55 publications

Blood Viscosity as a Determining Factor of Ischemic Stroke Outcomes Evaluated With Nihss and MRS on Day 7 and 30 Post-Thrombolysis

Blood Viscosity as a Determining Factor of Ischemic Stroke Outcomes Evaluated With Nihss and MRS on Day 7 and 30 Post-Thrombolysis

Association between Plasma Osmolality and Case Fatality within 1 Year after Severe Acute Ischemic Stroke

Conivaptan and Boric Acid Treatments in Acute Kidney Injury: Is This Combination Effective and Safe?

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