Conivaptan and Boric Acid Treatments in Acute Kidney Injury: Is This Combination Effective and Safe?

Can, Betül; Kar, Fatih; Kar, Ezgi; Özkoç, Mete; Şentürk, Hakan; Dönmez, Dilek Burukoğlu; Kanbak, Güngör; Alataş, İbrahim

doi:10.1007/s12011-021-02977-8

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…In their experimental renal ischemia and reperfusion (I/R) injury study, Can B et al observe a significant increase in inflammatory cytokine levels such as GSH and MDA compared to the control group. They showed that this situation improved when treated with boric acid in case of renal I/R injury 26 . Similarly, we observed that there was an increase in serum MDA levels in case of ACR toxicity and this situation improved when BA was applied.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Boric Acid in Preventing Acrylamide-Conducted Brain Damage in Rats

YİLDİZHAN

Ülger

Gündüz

et al. 2023

JoCASS

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Aim: Acrylamide (ACR) is a water-soluble neurotoxic substance that has been widely researched in recent years. Boric acid (BA) is a component that does not have a toxic effect when taken at low concentrations and has a cystotoxic activity. Studies have reported that BA has antioxidant effects. In this study, we aimed to examine the protective efficacy of BA against the toxic damage that ACR may cause in the brain tissue. Material: In this study, 28 Wistar Albino male rats with an average weight of 320-400 grams were used. In our study, ACR was administered intraperitoneally (i.p.) at a dose of 50 mg/kg for 14 days, while BA was administered orally (p.o.) with a dose of 200 mg/kg for 14 days. Group 1 (n=7): It is the control group and no medication was administered for 14 days. Group 2 (n=7): ACR group, Group 3 (n=7): BA group and Group 4 (n=7): ACR + BA group. Results: The comparison between the groups in terms of serum Total Oxidant Status (TOS) and Malondialdehyde (MDA) analysis revealed that the highest MDA level was in the ACR group. The MDA and TOS levels of the ACR+BA group were significantly lower than the ACR group (p

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Boric Acid in Preventing Acrylamide-Conducted Brain Damage in Rats

YİLDİZHAN

Ülger

Gündüz

et al. 2023

JoCASS

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“…Numerous studies have found that oxidative stress is an important pathway to alleviate sepsis induced AKI. 6,17,30 Tetrahydrocurcumin reduces oxidative stress by activating SOD and CAT, thereby preventing sepsis induced-AKI. 30 The levels of SOD1, SOD2, and CAT were found to decrease in cis-AKI, where SSF intervention significantly improved antioxidant activity, indicating a successful reduction in the excessive accumulation of ROS, thereby reducing the occurrence of ferroptosis.…”

Section: Discussionmentioning

confidence: 99%

“…5 Therefore, it is very necessary and urgent to find safe and effective drugs to protect kidneys. Studies have shown that boric acid can reduce oxidative stress, apoptosis and inflammatory response in the kidneys of I/R-AKI rats, thereby protecting renal function 6,7 Ferroptosis, a lately reported novel cell death mechanism, is characterized by intracellular lipid hydro-peroxidation and iron accumulation. 8 The cystine/glutamate antiporter (system Xc − ), iron metabolism, lipid peroxidation reaction, and p53 transcription factor have been shown to play essential roles in the occurrence of ferroptosis.…”

Section: Introductionmentioning

confidence: 99%

Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway

Jin,

He,

Lin

et al. 2023

DDDT

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Background: Acute kidney injury (AKI) is a common clinical condition resulting in a rapid decline in renal function, and requires improvement in effective preventive measures. Ferroptosis, a novel form of cell death, is closely related to AKI. Shenshuaifu granule (SSF) has been demonstrated to prevent AKI through suppressing inflammation and apoptosis.Objective: This study aimed to explore whether SSF can inhibit ferroptosis in AKI. Methods: Active ingredients in SSF were detected through HPLC-MS/MS, and their binding abilities with ferroptosis were evaluated by molecular docking. Then, male C57/BL/6J mice were randomly divided into control, cisplatin, and cisplatin+SSF groups. In the latter two groups, mice were intraperitoneally injected with 20 mg/kg of cisplatin. For five consecutive days prior to cisplatin injection, mice in the cisplatin+SSF group were gavaged with 5.2 g/kg of SSF per day. 72 h after cisplatin injection, the mice were sacrificed. Serum creatinine (SCr) and blood urea nitrogen (BUN) were measured to evaluate renal function. H&E and PAS staining were used to observe pathological damage of kidney. Cell death was observed by TUNEL staining, and iron accumulation in kidneys of mice was detected by Prussian blue staining. Western blotting, immunohistochemistry, and immunofluorescence were used to investigate the presence of inflammation, oxidative stress, mitochondrial dysfunction, iron deposition, and lipid peroxidation in mouse kidneys. Results: Active ingredients in SSF had strong affinities with ferroptosis. SSF reduced SCr (p<0.01) and BUN (p<0.0001) levels, pathological damage (p<0.0001), dead cells in the tubular epithelium (p<0.0001) and iron deposition (p<0.01) in mice with cisplatin induced AKI. And SSF downregulated macrophage infiltration (p<0.01), the expressions of high mobility group box 1 (HMGB1, p<0.05) and interleukin (IL)-17 (p<0.05), upregulated superoxide dismutase (SOD) 1 and 2 (p<0.01), and catalase (CAT, p<0.05), and alleviated mitochondrial dysfunction (p<0.05). More importantly, SSF regulated iron transport and intracellular iron overload and reduced the expression of ferritin (p<0.05). Moreover, it downregulated the expressions of cyclo-oxygenase-2 (Cox-2, p<0.001), acid CoA ligase 4 (ACSL4, p<0.05), and solute carrier family 7, member 11 (SLC7A11, p<001), upregulated glutathione peroxidase 4 (GPX4, p<0.01) and p53 (p<0.01), and decreased 4-hydroxynonenal (4-HNE) level (p<0.001). Conclusion: SSF attenuates AKI by inhibiting ferroptosis mediated by p53/SLC7A11/GPX4 pathway.

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Possible Curative Effects of Boric Acid and Bacillus clausii Treatments on TNBS-Induced Ulcerative Colitis in Rats

Özkoç

Can

Şentürk

et al. 2022

Biol Trace Elem Res

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Conivaptan and Boric Acid Treatments in Acute Kidney Injury: Is This Combination Effective and Safe?

Cited by 4 publications

References 47 publications

Effectiveness of Boric Acid in Preventing Acrylamide-Conducted Brain Damage in Rats

Effectiveness of Boric Acid in Preventing Acrylamide-Conducted Brain Damage in Rats

Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway

Possible Curative Effects of Boric Acid and Bacillus clausii Treatments on TNBS-Induced Ulcerative Colitis in Rats

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