Comprehensive hydrolytic degradation study of a new poly(ester-amide) used for total meniscus replacement

Miles, Catherine E.; Lima, Mariana R.N.; Buevich, Fatima; Gwin, Christine; Murthy, N. Sanjeeva; Kohn, Joachim

doi:10.1016/j.polymdegradstab.2021.109617

Cited by 10 publications

(8 citation statements)

References 45 publications

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“…The number of pores in a single unit of crystal was insufficient for the scaffold design, according to both porosity findings. However, the pore amount will increase after the ester segments of polyester urethane have easily degraded for a short period of time [41]. Porosity was determined using a similar concept to the Brunauer-Emmett-Teller method that was the relationship between area and volume [39].…”

Section: Determination Of Porositymentioning

confidence: 99%

Structural Characterization Analyses of Low Brass Filler Biomaterial for Hard Tissue Implanted Scaffold Applications

et al. 2022

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A biomaterial was created for hard tissue implanted scaffolds as a translational therapeutic approach. The existing biomaterials containing titanium dioxide filler posed a risk of oxygen gas vacancy. This will block the canaliculars, leading to a limit on the nutrient fluid supply. To overcome this problem, low brass was used as an alternative filler to eliminate the gas vacancy. Low brass with composition percentages of 0%, 2%, 5%, 15%, and 30% was filled into the polyester urethane liquidusing the metallic filler polymer reinforced method. The structural characterizations of the low brass filler biomaterial were investigated by Field Emission Scanning Electron Microscopy. The results showed the surface membrane strength was higher than the side and cross-section. The composition shapes found were hexagon for polyester urethane and peanut for low brass. Low brass stabilised polyester urethane in biomaterials by the formation of two 5-ringed tetrahedral crystal structures. The average pore diameter was 308.9 nm, which is suitable for articular cartilage cells. The pore distribution was quite dispersed, and its curve had a linear relationship between area and diameter, suggestive of the sphere-shaped pores. The average porosities were different between using FESEM results of 6.04% and the calculated result of 3.28%. In conclusion, this biomaterial had a higher surface membrane strength and rather homogeneous dispersed pore structures.

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Section: Determination Of Porositymentioning

confidence: 99%

Structural Characterization Analyses of Low Brass Filler Biomaterial for Hard Tissue Implanted Scaffold Applications

et al. 2022

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“…PLGA-Resomer 506 (50:50 ratio of lactic acid:glycolic acid) and PLLA-Resomer L 206 were purchased from Boehringer Ingelheim. Tyrosol-derived polymers were synthesized as previously described. , Dexamethasone was provided by Lubrizol Life Science. Water soluble poly(vinyl alcohol) (PVA, molecular weight 30,000–70,000 Da) was purchased from Sigma-Aldrich.…”

Section: Methodsmentioning

confidence: 99%

“…Tyrosol-derived polymers were synthesized as previously described. 27,33 Dexamethasone was provided by Lubrizol Life Science. Water soluble poly(vinyl alcohol) (PVA, molecular weight 30,000−70,000 Da) was purchased from Sigma-Aldrich.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Control of Drug Release from Microparticles by Tuning Their Crystalline Textures: A Structure–Activity Study

Miles

Bernstein

Popp

et al. 2021

ACS Appl. Polym. Mater.

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Predicting drug release profiles from polymer microparticles has proven challenging due to the numerous environmental and chemical factors that affect the device and influence the rate of drug release. By measuring the various polymer properties that can influence drug release, a predictive approach can be used to select polymers with specific properties that will lead to the desired release profile for the application. To illustrate this, a library of tyrosol-derived poly(ester-arylate)s, poly(amide)s, and poly(carbonate)s were used to evaluate the effects of physical (crystallinity, water accessibility, thermal, and hydrophobicity) and chemical (polymer−drug interactions) polymer properties on the release of a highly crystalline drug dexamethasone, which was loaded at a high weight percent (wt %) in microparticles. Nuclear magnetic resonance (NMR) experiments showed that the polymer and drug were not chemically interacting and instead exist as a physical mixture even after exposure to physiological conditions. Polymer crystallinity data revealed that crystallite size was strongly correlated with faster drug release, suggesting that larger crystallites reduce the tortuosity for dexamethasone to diffuse out of the particle matrix. This correlation observed in particles with and without the drug was reproduced with bulk polymers, indicating that crystallinity data from bulk polymers can be used to predict release profiles without having to prepare drug-loaded particles. Consistent with the crystallinity data, particle pore sizes of representative formulations showed that particles with larger pores resulted in faster dexamethasone release. Interestingly, thermal properties (glass transition temperature and melting temperature), polymer hydrophobicity, and molecular weight retention at the end of the 119-day release study did not show any correlation with drug release.

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“…29−31 Polyesters are favorable polymers for biomaterial applications as they contain a labile bond susceptible to hydrolytic and enzymatic degradation under in vitro conditions. 32,33 Recently, a novel polymer library was developed replacing tyrosine with tyrosol in order to remove the slow degrading amide bond, thereby improving the degradation and resorption of the polymer system while still maintaining its biocompatibility. 34 This research investigates the formulation of select tyrosolderived poly(ester-arylate)s using a continuous flow particle preparation method and shows how polymer properties affect drug loading and release compared to PLGA microparticles (Figure 1).…”

Section: ■ Introductionmentioning

confidence: 99%

“…Incorporating amphiphilic poly( l -amino acids) into the polymer backbone has resulted in polymers useful for drug delivery applications due to their ability to self-assemble into nanostructures, high drug encapsulation, and nontoxic degradation products . In particular, tyrosine containing poly(ester)s, poly(urethane)s, poly(amide)s, and poly(carbonate)s have paved the way for new nontoxic, biodegradable, and mechanically robust polymer libraries and have previously been used for drug delivery applications. − For example, tyrosine-derived poly(ester-amide)s have been used in self-assembling nanospheres for the delivery of hydrophobic cancer drugs. − Polyesters are favorable polymers for biomaterial applications as they contain a labile bond susceptible to hydrolytic and enzymatic degradation under in vitro conditions. , Recently, a novel polymer library was developed replacing tyrosine with tyrosol in order to remove the slow degrading amide bond, thereby improving the degradation and resorption of the polymer system while still maintaining its biocompatibility …”

Section: Introductionmentioning

confidence: 99%

Tyrosol Derived Poly(ester-arylate)s for Sustained Drug Delivery from Microparticles

Miles

Gwin

Zubris

et al. 2021

ACS Biomater. Sci. Eng.

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New biodegradable polymers are needed for use in drug delivery systems to overcome the high burst release, lack of sustained drug release, and acidic degradation products frequently observed in current formulations. Commercially available poly(lactide-co-glycolide) (PLGA) is often used for particle drug release formulations; however, it is often limited by its large burst release and acidic degradation products. Therefore, a biocompatible and biodegradable tyrosol-derived poly(ester-arylate) library has been used to prepare a microparticle drug delivery system which shows sustained delivery of hydrophobic drugs. Studies were performed using polymers with varying hydrophilicity and thermal properties and compared to PLGA. Various drug solubilizing cosolvents were used to load model drugs curcumin, dexamethasone, nicotinamide, and acyclovir. Hydrophobic drugs curcumin and dexamethasone were successfully loaded up to 50 weight percent (wt %), and a linear correlation between drug wt % loaded and the particle glass transition temperature (T g ) was observed. Both curcumin and dexamethasone were visible on the particle surface at 20 wt % loading and higher. By adjusting the polymer concentration during particle formation, release rates were able to be controlled. Release studies of dexamethasone loaded particles with a lower polymer concentration showed a biphasic release profile and complete release after 47 days. Particles prepared using a higher polymer concentration showed sustained release for up to 77 days. Comparably, PLGA showed a traditional triphasic release profile and complete release after 63 days. This novel tyrosol-derived poly(ester-arylate) library can be used to develop injectable, long-term release formulations capable of providing sustained drug delivery.

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Comprehensive hydrolytic degradation study of a new poly(ester-amide) used for total meniscus replacement

Cited by 10 publications

References 45 publications

Structural Characterization Analyses of Low Brass Filler Biomaterial for Hard Tissue Implanted Scaffold Applications

Structural Characterization Analyses of Low Brass Filler Biomaterial for Hard Tissue Implanted Scaffold Applications

Control of Drug Release from Microparticles by Tuning Their Crystalline Textures: A Structure–Activity Study

Tyrosol Derived Poly(ester-arylate)s for Sustained Drug Delivery from Microparticles

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