Comprehensive Annotation of Mature Peptides and Genotypes for Zika Virus

Sun, Guangyu; Larsen, Christopher N.; Baumgarth, Nicole; Klem, Edward B.; Scheuermann, Richard H.

doi:10.1371/journal.pone.0170462

Cited by 23 publications

(16 citation statements)

References 19 publications

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“…Richard Scheuermann, GVN center co-director at the J. Craig Venter Institute (USA), discussed using the Influenza Research Database (IRD, fludb.org) and the Virus Pathogen Resource (ViPR, viprbrc.org) to identify diagnostic peptide regions in Zika virus (ZIKV) and other flaviviruses. These databases identified 76 and 82 diagnostic amino acid sites from the ZIKV NS1 and E proteins, respectively, that distinguish it from other flaviviruses, with sensitivity/specificity above 98% (Sun et al, 2017). Similar numbers of such diagnostic sites were also identified for other flaviviral species.…”

Section: Arbovirusesmentioning

confidence: 69%

2016 International meeting of the Global Virus Network

et al. 2017

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The Global Virus Network (GVN) was established in 2011 in order to strengthen research and responses to current viral causes of human disease and to prepare against new viral pandemic threats. There are now 38 GVN Centers of Excellence and 6 Affiliate laboratories in 24 countries. GVN scientists meet annually to learn about each other's current research, address collaborative priorities and plan future programs. The 2016 meeting was held from October 23-25 in Hokkaido, Japan, in partnership with the Japanese Society for Virology, the National Institute of Infectious Diseases of Japan and the Research Center for Zoonosis Control of Hokkaido University. This report highlights the accomplishments of GVN researchers in many priority areas of medical virology, including the current Zika epidemic, infections by human papillomavirus, influenza, Ebola, Lassa, dengue, HIV, hepatitis C, and chikungunya viruses, and the development of improved diagnostics and new vaccines.

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Section: Arbovirusesmentioning

confidence: 69%

2016 International meeting of the Global Virus Network

et al. 2017

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“…Guangyu Sun analyzed 158 currently available full-length ZIKV genomes (as of Nov 2016) and found no complete recombination events however, same recombination event was identified for 3 genomes KF383117 (in PrM), KF383113 (in PrM), and KF383118 (in Env) [19]. A recent study revealed that ZIKV infection increased total P53 level, and nuclear accumulation of P53 Ser15 phosphorylation correlates with apoptosis induction and genotoxic stress.…”

Section: Molecular Evolutionmentioning

confidence: 90%

Advances in research on Zika virus

Ali

Wahid

Rafique

et al. 2017

Asian Pacific Journal of Tropical Medicine

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Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV started with a first outbreak in the Pacific area in 2007, a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands. Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine. Several vaccine platforms such as DNA vaccine, recombinant subunit vaccine, ZIKV purified inactivated vaccine, and chimeric vaccines have shown potent efficacy in vitro and in vivo trials. Moreover, number of drugs such as Sofosbuvir, BCX4450, NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity. Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women. In this review, we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines, molecular evolution, epidemiology emergence, neurological complications and other teratogenic outcomes as well as pathogenesis.

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“…Sun et al reported such data, to our knowledge for the irst time, using new computational methods for annotation of mature peptide proteins, genotypes, and recombination events for all ZIKV genomes [70]. In an efort to aid in the development of vaccines and therapeutic drugs, an integrative multi-omics platform, ZikaVR (htp:// bioinfo.imtech.res.in/manojk/zikavr/) was created by Gupta el at..…”

Section: Zika Virus Diseasementioning

confidence: 99%

The Impact of Bioinformatics on Vaccine Design and Development

María¹,

Arturo²,

Alicia³

et al. 2017

Vaccines

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Vaccines are the pharmaceutical products that ofer the best cost-beneit ratio in the prevention or treatment of diseases. In that a vaccine is a pharmaceutical product, vaccine development and production are costly and it takes years for this to be accomplished. Several approaches have been applied to reduce the times and costs of vaccine development, mainly focusing on the selection of appropriate antigens or antigenic structures, carriers, and adjuvants. One of these approaches is the incorporation of bioinformatics methods and analyses into vaccine development. This chapter provides an overview of the application of bioinformatics strategies in vaccine design and development, supplying some successful examples of vaccines in which bioinformatics has furnished a cuting edge in their development. Reverse vaccinology, immunoinformatics, and structural vaccinology are described and addressed in the design and development of speciic vaccines against infectious diseases caused by bacteria, viruses, and parasites. These include some emerging or re-emerging infectious diseases, as well as therapeutic vaccines to ight cancer, allergies, and substance abuse, which have been facilitated and improved by using bioinformatics tools or which are under development based on bioinformatics strategies.

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Comprehensive Annotation of Mature Peptides and Genotypes for Zika Virus

Cited by 23 publications

References 19 publications

2016 International meeting of the Global Virus Network

2016 International meeting of the Global Virus Network

Advances in research on Zika virus

The Impact of Bioinformatics on Vaccine Design and Development

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