Comprehensive analysis of the immune implication of FABP4 in colon adenocarcinoma

Wu, Dabin; Ling, Xiang; Peng, Linglong; Gu, Haitao; Tang, Yun-Hao; Luo, Haoyun; Liu, Huan; Wang, Yaxu

doi:10.1371/journal.pone.0276430

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Recently, it has been suggested that FABP4 is involved in the progression and poor outcomes of several major human cancers. FABP4 expression was found to affect immune cell infiltration in colon cancer [ 47 ]. Exogenous FABP4 significantly increased the proliferation and migration of human hepatocellular cancer cells [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated serum fatty acid-binding protein 4 level predicts all-cause and cardiovascular mortality in peritoneal dialysis patients: a five-year study

Zhou,

Wang,

Han

et al. 2023

Renal Failure

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Background To explore the prospective role of serum fatty acid-binding protein 4 (FABP4) in the outcomes of peritoneal dialysis (PD) patients. Methods A prospective observational study was conducted with 159 patients on PD. Demographic and clinical data at baseline were collected from medical records. Biochemical data were recorded based on blood samples measured in a central laboratory. Serum FABP4 concentrations were determined using enzyme-linked immunosorbent assay. Body composition was measured using a Body Composition Monitor. Abdominal lateral plain radiography was used to evaluate vascular calcification. The primary endpoints were all-cause and cardiovascular death. Results The median of serum FABP4 concentration was 154.6 ng/mL (interquartile range, 132.8–269.7 ng/mL). Increased serum FABP4 was associated with increased vascular calcification proportion, time on dialysis, body mass index, high-sensitivity C-reactive protein (hs-CRP), intact parathyroid hormone (iPTH), triglycerides, body fat mass, and body fat percentage ( p < 0.05). Increased serum FABP4 was associated with decreased residual kidney Kt/V urea ( p < 0.05). Patients with hs-CRP≥ 3 mg/L had significantly higher serum FABP4 than those with hs-CRP< 3 mg/L ( p < 0.05). Patients with vascular calcification had significantly higher serum FABP4 than those without vascular calcification ( p < 0.05). During a median follow-up of 58.0 months, 58 all-cause deaths and 26 cardiovascular deaths occurred. High serum FABP4 levels were independently predictive for all-cause [hazard ratio (HR), 1.003; 95% confidence interval (CI), 1.001–1.005; p = 0.016] and cardiovascular death (HR, 1.005; 95% CI, 1.001–1.008; p = 0.006) in PD patients. Conclusions Increased serum FABP4 levels can independently predict all-cause and cardiovascular death in patients on PD.

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Section: Discussionmentioning

confidence: 99%

Elevated serum fatty acid-binding protein 4 level predicts all-cause and cardiovascular mortality in peritoneal dialysis patients: a five-year study

Zhou,

Wang,

Han

et al. 2023

Renal Failure

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“…The TNFRSF14 membrane-bound receptor binds several ligands mediating both coinhibitory and costimulatory pathways. Therefore, TNFRSF14 regulates immune cell homeostasis ( 62 – 64 ). In accordance, among its ligands, we found that it down-regulated the B- and T-lymphocyte attenuator ( btla ) gene, a member of the CD28 family, and its interaction with TNFRSF14 delivers a coinhibitory signal regulating T-cell activation ( 65 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary Debaryomyces hansenii promotes skin and skin mucus defensive capacities in a marine fish model

Sanahuja,

Fernandez-Alacid,

Torrecillas

et al. 2023

Front. Immunol.

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The present study explores the effects of two supplementation levels of Debaryomyces hansenii (1.1% and 2.2%) as a probiotic in a reference low fish meal-based diet on the skin mucosal tissue in Sparus aurata. This study includes the evaluation of fish performance coupled with a holistic study of the skin mucosa: i) a transcriptomic study of the skin tissue, and ii) the evaluation of its secreted mucus both in terms of skin mucosal-associated biomarkers and its defensive capacity by means of co-culture analysis with two pathogenic bacteria. Results showed that after 70 days of diet administration, fish fed the diet supplemented with D. hansenii at 1.1% presented increased somatic growth and a better feed conversion ratio, compared to fish fed the control diet. In contrast, fish fed the diet including 2.2% of the probiotic presented intermediate values. Regarding gene regulation, the probiotic administration at 1.1% resulted in 712 differentially expressed genes (DEGs), among which 53.4% and 46.6% were up- and down-regulated, respectively. In particular, D. hansenii modulated some skin biological processes related to immunity and metabolism. Specifically, D. hansenii administration induced a strong modulation of some immune biological-related processes (61 DEGs), mainly involved in B- and T-cell regulatory pathways. Furthermore, dietary D. hansenii promoted the skin barrier function by the upregulation of anchoring junction genes (23 DEGs), which reinforces the physical defense against potential skin damage. In contrast, the skin showed modulated genes related to extracellular exosome and membrane organization (50 DEGs). This modulated functioning is of great interest, particularly in relation to the increased skin mucus defensive capacity observed in the bacterial co-culture in vitro trials, which could be related to the increased modulation and exudation of the innate immune components from the skin cells into the mucus. In summary, the modulation of innate immune parameters coupled with increased skin barrier function and cell trafficking potentiates the skin’s physical barrier and mucus defensive capacity, while maintaining the skin mucosa’s homeostatic immune and metabolic status. These findings confirmed the advantages of D. hansenii supplementation in low fish meal-based diets, demonstrating the probiotic benefits on cultured marine species.

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“…In the largest of the two studies (100 CRC cases), it was also shown that FABP-4 expression was statistically significantly higher in tumor tissues than in adjacent tissues [ 20 ]. In research focusing on colon adenocarcinoma, a higher FABP-4 expression has been observed in tumor than in adjacent tissues [ 21 ] and FABP4 was part of an 11-gene risk score that predicts recurrence of colon adenocarcinoma [ 22 ]. Collectively, laboratory and epidemiological research suggests the potential involvement of FABP-4 in CRC development.…”

Section: Introductionmentioning

confidence: 99%

Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer

Nimptsch,

Aleksandrova,

Pham

et al. 2023

BMC Med

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Background Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach. Methods The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Results In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95% confidence interval, CI) per one standard deviation, SD (8.9 ng/mL) higher FABP-4 concentration was 1.01 (0.92, 1.12) overall, 0.95 (0.80, 1.13) in men and 1.09 (0.95, 1.25) in women. Genetically determined higher FABP-4 was not associated with colorectal cancer risk (RR per FABP-4 SD was 1.10 (0.95, 1.27) overall, 1.03 (0.84, 1.26) in men and 1.21 (0.98, 1.48) in women). However, in a cis-MR approach, a statistically significant association was observed in women (RR 1.56, 1.09, 2.23) but not overall (RR 1.23, 0.97, 1.57) or in men (0.99, 0.71, 1.37). Conclusions Taken together, these analyses provide no support for a causal role of circulating FABP-4 in the development of CRC, although the cis-MR provides some evidence for a positive association in women, which may deserve to be investigated further.

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Comprehensive analysis of the immune implication of FABP4 in colon adenocarcinoma

Cited by 3 publications

References 29 publications

Elevated serum fatty acid-binding protein 4 level predicts all-cause and cardiovascular mortality in peritoneal dialysis patients: a five-year study

Elevated serum fatty acid-binding protein 4 level predicts all-cause and cardiovascular mortality in peritoneal dialysis patients: a five-year study

Dietary Debaryomyces hansenii promotes skin and skin mucus defensive capacities in a marine fish model

Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer

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