Comprehensive analysis of phenolic compounds and abscisic acid profiles of twelve native Canadian berries

Dudonné, Stéphanie; Dubé, Pascal; Anhê, Fernando F.; Pilon, Geneviève; Marette, André; Lemire, Mélanie; Harris, Cory S.; Dewailly, Éric; Desjardins, Yves

doi:10.1016/j.jfca.2015.09.003

Cited by 71 publications

(50 citation statements)

References 44 publications

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“…Phenolic characterization of blueberry extract and polyphenolic fractions. The polyphenol composition analysis was carried out as described previously 58 . Flavonols, flavan-3-ols and phenolic acids were analyzed as published before 58 using reverse-phase UHPLC-MS/MS, where data were acquired in scan mode (m/z 100-1000).…”

Section: Methods Polyphenols Fractionationmentioning

confidence: 99%

Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice

Rodríguez-Daza

Daoust

Boutkrabt

et al. 2020

Sci Rep

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Blueberries are a rich source of polyphenols, widely studied for the prevention or attenuation of metabolic diseases. However, the health contribution and mechanisms of action of polyphenols depend on their type and structure. Here, we evaluated the effects of a wild blueberry polyphenolic extract (WBe) (Vaccinium angustifolium Aiton) on cardiometabolic parameters, gut microbiota composition and gut epithelium histology of high-fat high-sucrose (HfHS) diet-induced obese mice and determined which constitutive polyphenolic fractions (BPF) was responsible for the observed effects. To do so, the whole extract was separated in three fractions, F1) Anthocyanins and phenolic acids, F2) oligomeric proanthocyanidins (PACs), phenolic acids and flavonols (PACs degree of polymerization DP < 4), and F3) PACs polymers (PACs DP > 4) and supplied at their respective concentration in the whole extract. After 8 weeks, WBE reduced OGTT AUC by 18.3% compared to the HFHS treated rodents and the F3 fraction contributed the most to this effect. The anthocyanin rich F1 fraction did not reproduce this response. WBE and the BPF restored the colonic mucus layer. Particularly, the polymeric PACs-rich F3 fraction increased the mucin-secreting goblet cells number. WBE caused a significant 2-fold higher proportion of Adlercreutzia equolifaciens whereas oligomeric PACs-rich F2 fraction increased by 2.5-fold the proportion of Akkermansia muciniphila. This study reveals the key role of WBE PACs in modulating the gut microbiota and restoring colonic epithelial mucus layer, providing a suitable ecological niche for mucosa-associated symbiotic bacteria, which may be crucial in triggering health effects of blueberry polyphenols.Wild blueberries (Vaccinium angustifolium Aiton) are recognized as a rich source of bioactive phenolic compounds, the consumption of which has been associated with the attenuation of metabolic disorders through its beneficial action on glucose homeostasis and the reduction the oxidative stress and intestinal inflammation 1,2 . Until now, these positive effects have predominantly been attributed to flavonoids and in particular to anthocyanins 3,4 . However, wild blueberry has a complex profile of bioactive polyphenols; in addition to anthocyanins, it contains chlorogenic acid, and oligomers and polymers of flavan-3-ols, such as proanthocyanidins (PACs) 5 . Interestingly, there are increased evidences showing that PACs can attenuate the progression of metabolic syndrome, including type 2 diabetes and obesity 6 . Pre-clinical studies have suggested different mechanisms by Figure 3. Wild blueberry polyphenolic fractions restore the mucus thickness and polymeric PACs-rich fraction significantly stimulated mucin-secreting goblet cells number in HFHS-fed mouse colon. The effect of HFHS-diet and the supplementation with WBE and BPF: anthocyanin and phenolic acids (F1), oligomeric PACs, phenolic acids and flavonols (F2) and polymeric PACs (F3) were studied in mouse colon morphology. A combination of Alcian Blue and periodic acid-Schiff...

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Section: Methods Polyphenols Fractionationmentioning

confidence: 99%

Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice

Rodríguez-Daza

Daoust

Boutkrabt

et al. 2020

Sci Rep

Self Cite

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“…2 Total phenolic content (TPC) expressed as mg GA g −1 DW. 3 Total flavonoid content (TFC) expressed as mg RUT g −1 DW. 4 Total anthocyanin content (TAC) expressed as mg Cya-3-Glu g −1 DW.…”

Section: Selection Of the Most Effective Nades For The Extraction Of mentioning

confidence: 99%

“…Consequently, many researchers have focused on the investigation of bioactive compounds (especially those from the polyphenol classes) from various plant materials [1,2]. Recent studies have shown that berries contain the highest number of phenolic compounds and have the highest antioxidant activity among other fruits [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

et al. 2020

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For the isolation of selected phenolic compounds from dried chokeberries, natural deep eutectic solvents (NADESs) were investigated as a green alternative to conventionally used extraction solvents. Four types of NADESs were synthesised, with choline chloride as the hydrogen bond acceptor in combination with different hydrogen bond donors (sugars, organic acid and urea). Ultrasound-assisted extraction was used to improve the extractability of the phenolic compounds and the results were compared to those obtained with 80% methanol as the extraction media. The highest values of total phenols and total flavonoids were found in the extract obtained with choline chloride–fructose NADES (36.15 ± 3.39 mg gallic acid g−1 dry weight (DW) and 4.71 ± 0.33 mg rutin g−1 DW, respectively). The extraction recoveries for the individual phenolic compounds depended strongly on the phenolic compound’s structure, with relative mean values between 70% and 97%.

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“…The characterization of bioactive compounds like carotenoids and phenolics in edible native plants and the effect on them of processing is always a timely research topic …”

Section: Introductionmentioning

confidence: 99%

“…The characterization of bioactive compounds like carotenoids and phenolics in edible native plants and the effect on them of processing is always a timely research topic. 13,14 The interest in natural antioxidants found in plants has also increased due to the worldwide increase in using plant extracts as additives in food. Taking into account this consideration, the main objective of this study was to characterize for the first time the phenolic and carotenoid composition and antioxidant capacity of I. guayusa.…”

Section: Introductionmentioning

confidence: 99%

Guayusa (Ilex guayusa L.) new tea: phenolic and carotenoid composition and antioxidant capacity

et al. 2017

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Comprehensive analysis of phenolic compounds and abscisic acid profiles of twelve native Canadian berries

Cited by 71 publications

References 44 publications

Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice

Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

Guayusa (Ilex guayusa L.) new tea: phenolic and carotenoid composition and antioxidant capacity

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