Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species

Abstract

This study is the first to demonstrate the MMP, tyrosinase and ROS inhibiting properties of multiple different phytochemical components derived from quinoa seeds. Our work indicates that quinoa phytochemicals may play a role in the treatment and prevention of skin ageing through a multiplicity of effects.

Phytochemicals in quinoa and amaranth grains and their antioxidant, anti‐inflammatory, and potential health beneficial effects: a review

“…Phytoecdysteroids isolated from the seeds of quinoa were demonstrated to be potent protective agents to prevent or delay both collagenase‐related skin damages and oxidative stress . The oil and phytoecdysone, and other phytochemicals of quinoa significantly inhibited MMP‐1 mRNA expression and MMP‐9 and tyrosinase enzymatic activities, and reduced intracellular ROS production in a human dermal fibroblasts cell model, suggesting quinoa phytochemicals may play a role in the treatment and prevention of skin ageing through a multiplicity of effects . Squalene in amaranth seed oil was also found to help reduce oxidative damage to the skin .…”

“…Its content is reported to be 184 ‐ 484 mg/kg in quinoa . A recent study showed that quinoa seed leachate containing 20HE inhibited matrix metalloproteinase (MPP) activity and production of intracellular ROS . No data is available for amaranth seed, however, Gomphrena haageana , a plant that belongs to the same family as quinoa and amaranth contained as high as 2580 mg/kg seed .…”

“…The hydrophilic and lipophilic fractions of quinoa seed significantly inhibited MMP, catalase and glutathione and tyrosinase activities and intracellular ROS production in cultured cells and were suggested to play a role in preventing skin aging, an oxidation process . Diet supplemented with quinoa seeds reduced oxidative stress in plasma, heart, kidney, liver, spleen, lung, testis and pancreas of fructose administered rats and inhibited plasma lipid peroxidation as seen in significantly lowered plasma malondialdehyde (MDA) concentration.…”

Innovations in Health Value and Functional Food Development of Quinoa (Chenopodium quinoa Willd.)

“…Studies in high‐fat‐diet mice have linked 20HE's anti‐obesity and antidiabetic activity to reduced dietary lipid absorption, increased glucose oxidation, increased energy expenditure (Foucault and others ), and enhanced mitochondrial oxidative phosphorylation (Wang and others ). In addition, 20HE has been shown to attenuate oxidative stress in 3 different mammalian cell lines (Hu and others , ; Graf and others ). Meanwhile, 20HE may affect mammalian gene expression, resulting in activation of the anabolic P13K/Akt pathway (Dinan and Lafont ; Gorelick‐Feldman and others ), and downregulation of the hepatic gluconeogenesis pathway (Kizelsztein and others ).…”

Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

“…The phenolic-rich (17.4 % ± 0.67 %) extract of Chenopodium quinoa Willd., Chenopodiaceae or quinoa inhibited mushroom TYR activity at concentrations of 0.5 and 1.0 mg/mL (56.7 % and 77.0 %, respectively; p < 0.001 and p < 0.0001, respectively), although it was less potent than kojic acid (4) (45.7 % at 0.01 mg/ mL) [31].…”