Compounds isolated from Eriobotrya deflexa leaves protect against ultraviolet radiation B-induced photoaging in human fibroblasts

Huang, Chiou-Jye; Lin, Yi; Kuo, Hsiang Chun; Chiou, Wen Fei; Lee, Mei Hsien

doi:10.1016/j.jphotobiol.2017.08.042

Cited by 16 publications

(9 citation statements)

References 41 publications

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“…fruit by HPLC analysis, which is consistent with a previous report [13]. Hyperin has been identified as an antioxidant with ROS scavenging ability that can enhance skin density and elasticity by mediating MMP-1 and type-I procollagen expression [32]. We speculate that the antioxidant and anti-photoaging effects of E-EA are due to the hyperin.…”

Section: Discussionsupporting

confidence: 92%

Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

She

Yuan

Zhang

et al. 2019

ARCH BIOL SCI BELGRA

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Rubus chingii Hu. is an important traditional Chinese medicine with a beneficial effect on the kidney. Traditional Chinese medicine theory believes that supporting the kidney has a key role in anti-aging. To the best of our knowledge, the anti-photoaging activity of Rubus chingii Hu. has not been investigated. We investigated the anti-photoaging effects and the underlying mechanism of the ethyl acetate fraction of Rubus chingii Hu. fruit ethanol extract (E-EA) in UVB-induced human fibroblasts (HFF-1). Our results show that E-EA (10-40 μg/mL) displayed preventive and therapeutic effects on UVB-induced cytotoxicity in HFF-1 cells. E-EA also presented significant anti-photoaging properties in UVB-induced HFF-1 cells by decreasing the levels of reactive oxygen species (ROS), inhibiting matrix metallopeptidase 1 (MMP-1) production and promoting type-I procollagen production via suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. These results suggested that E-EA might be a promising anti-photoaging agent to protect the skin from UVB damage, with a potential application in cosmetics.

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Section: Discussionsupporting

confidence: 92%

Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

She

Yuan

Zhang

et al. 2019

ARCH BIOL SCI BELGRA

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“…When the MAPK signaling pathway is activated, downstream targets of this signaling cascade such as JNK, p38, and ERK are phosphorylated, and transcription factors such as AP-1 are activated, which together stimulate the expression of matrix metalloproteinases (MMPs) [10]. Both downregulation of the TGF-β signaling pathway and upregulation of MAPK signaling have been observed in dermal fibroblasts exposed to various extrinsic factors including UV irradiation [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts

et al. 2019

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Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced photoaging in human Hs68 dermal fibroblasts and identified the mechanisms involved. We found that in human dermal fibroblasts, α-ionone inhibited UVB-induced loss of collagen. α-Ionone upregulated the molecules participating in the TGF-β–SMAD pathway (TGF-β1, phospho-SMAD2/3, Col1A1, and Col1A2), but downregulated the molecules involved in the MAPK–AP-1 signaling pathway (phospho-p38, phospho-JNK, phospho-ERK, phospho-c-Fos, phospho-c-Jun, MMP1, MMP3, and MMP9), in human dermal fibroblasts. α-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Thus, α-ionone is effective in the prevention of UVB-induced decrease of collagen and hyaluronic acid in human dermal fibroblasts. We propose that α-ionone may prove beneficial for the prevention of UV-induced wrinkle formation and skin damage.

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“…Phenols and flavonoids, the main constituents in flowers, were considered as antioxidants and UV absorbing secondary metabolites [18,19]. It has also been reported that flavonoids help to prevent the skin photoaging by regulating pro-inflammatory cytokines [20,21]. Interestingly, abundant phenols and flavonoids were found in the BEE and FEE, respectively.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages

Dong

Liu

et al. 2019

Antioxidants

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Paeonia suffruticosa is an ornamental, edible, and medicinal plant. The ethanolic extracts of P. suffruticosa bud and flower were examined for their antioxidant, anti-photoaging, and phytochemical properties prior to chemometric analysis. The results showed that the bud ethanolic extract (BEE) and the flower (the early flowering stage) ethanolic extract (FEE) had better antioxidant activities, and significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and reduced the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the skin tissues. In total, 68 compounds, including 20 flavonoids, 15 phenolic derivatives, 12 terpenoids, 9 fatty acids, and 12 others were identified or tentatively identified by ultra-fast liquid chromatography quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF-MS). Gallic acid, 1,2,3,4,6-O-pentagalloyl glucose, paeoniflorin, and oxypaeoniflorin were predominant compounds in the extracts. Taken together, P. suffruticosa flowers are a candidate for functional material in food and health related industries, and their optimal time to harvest is before the early flowering stage.

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Compounds isolated from Eriobotrya deflexa leaves protect against ultraviolet radiation B-induced photoaging in human fibroblasts

Cited by 16 publications

References 41 publications

Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

Protective effect of the Rubus chingii Hu. fruit extract on ultraviolet B-induced photoaging via suppression of mitogen-activated protein kinases (MAPKs) in vitro

α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts

Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages

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