Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages

Abstract

Paeonia suffruticosa is an ornamental, edible, and medicinal plant. The ethanolic extracts of P. suffruticosa bud and flower were examined for their antioxidant, anti-photoaging, and phytochemical properties prior to chemometric analysis. The results showed that the bud ethanolic extract (BEE) and the flower (the early flowering stage) ethanolic extract (FEE) had better antioxidant activities, and significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and reduced the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the skin tissues. In total, 68 compounds, including 20 flavonoids, 15 phenolic derivatives, 12 terpenoids, 9 fatty acids, and 12 others were identified or tentatively identified by ultra-fast liquid chromatography quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF-MS). Gallic acid, 1,2,3,4,6-O-pentagalloyl glucose, paeoniflorin, and oxypaeoniflorin were predominant compounds in the extracts. Taken together, P. suffruticosa flowers are a candidate for functional material in food and health related industries, and their optimal time to harvest is before the early flowering stage.

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

“…In a recent study, it was found that paeoniflorin can reduce the response injury of astrocytes and microglia by inhibiting the phosphorylation of apoptotic signal‐regulating kinase 1 (ASK1), inhibiting its neuroinflammatory effect and treating chronic neuropathic pain in rats . It is worth noting that paeoniflorin also has pharmacological activities such as hypoglycaemic and lipid‐lowering, antioxidant and antiphotoaging …”

“…[92] It is worth noting that paeoniflorin also has pharmacological activities such as hypoglycaemic and lipid-lowering, antioxidant and antiphotoaging. [93,94] [84] 0.01, 0.1, 0.5, 1.0, 2.0 mg/ml…”

Cleavage rules of mass spectrometry fragments and rapid identification of chemical components of Radix Paeoniae Alba using UHPLC‐Q‐TOF‐MS

“…The product ion at m/z 283.0357 was produced via the loss of the monoterpene (C 10 H 12 O 4 ) core of the precursor ions. Based on the secondary fragmentation data and mass spectral fragmentation behaviour, compound 1 was identified as paeoniflorin 14,15 . The fragmentation pathway of paeoniflorin in the negative ion mode is illustrated in Figures 3 and 4.…”

pH-Sensitive Dairy-Derived Hydrogels with a Prolonged Drug Release Profile for Cancer Treatment

“…As a rule, TAs are considered non-toxic in small doses [ 13 , 14 ] and exhibit antitumor effects [ 15 ]. The presence of TA in natural components can reduce tumor necrosis factor levels [ 16 ] and weaken the inflammatory cytokine expression [ 17 ]. Previously, it was shown that TA crosslinked into a compacting collagen gel predominantly inhibited proliferation of high-melanoma A375 cells with metastatic potential [ 18 ].…”