Compositional analysis of Scottish honeys with antimicrobial activity against antibiotic-resistant bacteria reveals novel antimicrobial components

Fyfe, Lorna; Okoro, Paulina; Paterson, Euan; Coyle, Shirley; McDougall, Gordon J.

doi:10.1016/j.lwt.2017.01.023

Cited by 48 publications

(53 citation statements)

References 32 publications

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“…On the other hand, the lowest phenolic content and FRAP activity were determined in white Portobello Scottish honey, 183 mg GAE/kg and 1.91 mmol Fe 2+ /kg, respectively. A correlation between the TPC and FRAP assay was also found (44). The results of our study revealed that amber honeys possess stronger antioxidant activity than lighter honeys and that there was a significant correlation between honey color and the FRAP antioxidant activity.…”

Section: Resultssupporting

confidence: 74%

Total Phenolic and Flavonoid Contents, Antioxidant and Antibacterial Activities of Selected Honeys Against Human Pathogenic Bacteria

Živković¹,

Sunarić²,

Stanković³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Section: Resultssupporting

confidence: 74%

Total Phenolic and Flavonoid Contents, Antioxidant and Antibacterial Activities of Selected Honeys Against Human Pathogenic Bacteria

Živković¹,

Sunarić²,

Stanković³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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“…One of them, 2-DecDA was also detected in New Zealand manuka, kanuka and white clover unifloral honeys in concentrations from 3.5 to 181.2 μg/g (Tan et al, 1988). Recently, 2-decenedioic acid and its glycoside were investigated in some Scottish honeys, but the exact chemical structures of the components were not determined (Fyfe et al, 2017). The quantity of the aliphatic royal jelly acids in different samples of genuine honey and herbhoney varied from 6 to 209 μg/g (n = 65; Isidorov et al, 2012, and unpublished data).…”

Section: Discussionmentioning

confidence: 99%

Royal Jelly Aliphatic Acids Contribute to Antimicrobial Activity of Honey

Isidorow

Witkowski

Iwaniuk

et al. 2018

Journal of Apicultural Science

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Honey is valued for its therapeutic qualities which are attributed among others to its antibacterial multifactorial properties. However, all the factors that influence these properties have not been identified. The present study is focused on the antibacterial action of fatty acids originating from royal jelly, the larval food of honeybees. Aliphatic C8-C12 acids characteristic of this bee product had previously been identified in more than fifty different samples of honey originating from seven countries and in eleven samples of Polish herbhoney. Experiments were performed to ascertain the influence of acidity on the antimicrobial activity of the acids. In acidic nutrient media all tested aliphatic hydroxyacids and unsaturated dicarboxylic acids demonstrated antibacterial action against different microbes with minimal inhibitory concentrations between 0.048 and 3.125 mM. Our results confirm that part of the antibacterial activity of honey contributes to these compounds of bee origin.

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“…The main bioactive substances of honey are a wide range of phenolic compounds: gallic acid, caffeic acid, p ‐coumaric acid, quercetin, kaempferol, and so on (M Alvarez‐Suarez and others ). With the deepening of research, the varied effects of honey have been reported by plenty of researchers such as antimicrobial (Fyfe and others ), anti‐inflammatory (Kassim and others ), antidiabetes (Whitfield and others ), and hepatoprotective effect (Cheng and others ). However, there is no report regarding the protective effects of honey on bromobenzene‐induced liver damage, even though it is a typical chemical liver injury related to oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of the Honey of Apis cerana Fabricius on Bromobenzene‐Induced Liver Damage in Mice

Zhao

Cheng

et al. 2018

Journal of Food Science

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Apis cerana honey (honey of Apis cerana Fabricius), widely distributed in the mountain areas of East Asia, has not been studied fully. The hepatoprotective activity of A. cerana honey was evaluated against bromobenzene-induced liver damage in mice. In high dose, A. cerana honey can significantly alleviate liver injury, as is indicated by the depressed levels of serum alanine aminotransferase (ALT) (59.13%) and aspartate aminotransferase (AST) (79.71%), the inhibited malondialdehyde (MDA) content (63.30%), the elevated activities of superoxide dismutase (SOD) (73.12%) and glutathione-Px (57.24%), and the decreased expression of Transforming growth factor β1 (51.83%) induced by bromobenzene (P < 0.05). The quantitative analysis of twelve major constituents (1 to 12) of A. cerana honey was executed by high performance liquid chromatography-diode array detector. The results indicate that treatment with A. cerana honey can prevent bromobenzene-induced hepatic damage in mice. Polyphenols might be the bioactive substances attributed to its antioxidant properties and intervention of oxidative stress.

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Compositional analysis of Scottish honeys with antimicrobial activity against antibiotic-resistant bacteria reveals novel antimicrobial components

Cited by 48 publications

References 32 publications

Total Phenolic and Flavonoid Contents, Antioxidant and Antibacterial Activities of Selected Honeys Against Human Pathogenic Bacteria

Total Phenolic and Flavonoid Contents, Antioxidant and Antibacterial Activities of Selected Honeys Against Human Pathogenic Bacteria

Royal Jelly Aliphatic Acids Contribute to Antimicrobial Activity of Honey

Hepatoprotective Effects of the Honey of Apis cerana Fabricius on Bromobenzene‐Induced Liver Damage in Mice

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