Composition of the oily compounds, phytochemical screening and biological activity of different aerial parts of Smirnovia turkestana Bunge

Abstract

In the present study, chemical composition of the oily compounds isolated from different parts of Smirnovia turkestana (Kashan, central Iran) using n-hexane was determined for the first time. GC-MS analysis revealed that dodecanoic acid, trans-β-ionone and methyl palmitate are the major components of leaves extract. Trans-β-ionone and hexadodecanoic acid were also, identified as the major compounds of flowers extract. Heptacosane, trans-β-ionone and vitamin E acetate were the main components of fruits. Phytochemical screening of the methanol extract proved the presence of alkaloids, anthraquinones, flavonoids and anthocyanin in the leaves, flowers and fruits of S. turkestana, while tannins were present only in its fruits. Evaluation of the biological activities showed that different aerial parts of S. turkestana have high antioxidant activities; antimicrobial activities were also considerable against some selected bacteria.

Methyl Palmitate—A suitable adjuvant for Sorafenib therapy to reduce in vivo toxicity and to enhance anti‐cancer effects on hepatocellular carcinoma cells

“…The second focus of this study was to analyse the potency of MP in reducing in vivo toxicity of Sorafenib using a promising zebra fish model 59 . The leaf extracts of different plants having MP as main constituent exhibited cytotoxicity, anti‐angiogenesis, anti‐proliferative and apoptosis induction activities on many human cancer cells 40,60‐63 . An in vivo study has proven the hepato‐protective property of MP without causing toxic effects 45 .…”

“…59 The leaf extracts of different plants having MP as main constituent exhibited cytotoxicity, anti-angiogenesis, anti-proliferative and apoptosis induction activities on many human cancer cells. 40,[60][61][62][63] An in vivo study has proven the hepato-protective property of MP without causing toxic effects. 45 From our study results, we conclude that the 3 mmol/L of MP used in this study is a safer dose as the higher tested concentration (5 nmol/L) did not show toxicity to the embryos.…”

Optimization of microwave assisted extraction of essential oils from Iranian Rosmarinus officinalis L. using RSM

“…The oven temperature was increased from 80 to 320°C at a rate of 3°C/min and kept for 5 min at 320°C. Then heated to 250°C and finally, held for 3 min at 250°C (Akhbari et al 2017).…”