COMPOSITION OF EPIPHYSEAL CARTILAGE: I. CHANGES IN HEXOSAMINE AND ACETONE EXTRACTABLE CONTENTS OF EPIPHYSEAL CARTILAGE OF RACHITIC CHICKS FOLLOWING ADMINISTRATION OF VITAMIN D<sub>a</sub>

Cipera, J. D.; Migicovsky, B. B.; Bélanger, Louise

doi:10.1139/o60-098

Cited by 10 publications

(4 citation statements)

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“…Even the ratios of total hexosamine to hydroxyproline and glycosaminoglycans to hydroxyproline were consistently higher in vitamin D deficiency. As mentioned earlier it has been reported that the hexosamine content of the epiphyseal cartilage is decreased or increased (Cipera et al 1960) in healing rickets, while no differences were observed as to the glycosaminoglycans content (Hjertquist 1964 a). There have been no previous reports concerning the glycosaminoglycans content of rachitic diaphyseal cortical bone.…”

Section: Discussionmentioning

confidence: 84%

“…A slight increase in hexosamine content of rachitic chicken cartilage 48 hours after administration of vitamin D has also been reported (Cipera et al 1960). In the latter case no changes in the ash content was found.…”

Section: )mentioning

confidence: 82%

“…Usually no differences from the corresponding values for the control rats. Despite numerous studies of the inorganic component of the skeleton in vitamin D deficiency and some studies of the organic fraction as well, , Cipera et al 1960 there are no reports on the chemical composition of cortical bone, especially its organic fraction in rickets. An investigation was, therefore, carried out with this special objective (Hjertquist et al 1970) the results of which are summarized in Table II.…”

Section: Percentage Of the Total Dry Weightmentioning

confidence: 99%

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Vitamin D and Skeletal Metabolism: Experimental Studies in the Rat

Sevastikoglou¹,

Ray²,

Hjertquist³

et al. 1970

Acta Orthopaedica Scandinavica

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References 73 82 FOREWORDThere are few topics in medicine, that have attracted the interest of so many investigators as the physiological significance(s) of Vitamin D. However, in spite of extensive research and innumerable publications, knowledge concerning the mode of action of the vitamin on the calcium homeostasis of the body is still incomplete.The complexity of the "simple question" how does vitamin D influence skeletal metabolism? defies a simple experimental solution and requires an integrated, multilevel approach. With this in mind the authors have during the last years tried to throw some light on the question by conducting a correlated series of experimental investigations. The study started in Chicago, Illinois, was continued in the Orthopaedic Research Laboratory in Uppsala and later in Umea, Sweden. The results were discussed at each stage by the senior authors (J. A. S. and R. D. R.) and each step was planned in close collaboration.The results of these studies reinforce certain previous findings under standard conditions not prevalent in the multitude of separate studies in separate laboratories by separate people in the past, and add new aspects on the mechanism of action of vitamin D on bone.The publication of the different sections of the work in the form of a supplementum was chosen since it gives a more coherent survey of the results obtained.The investigations were aided by grants from the U. S. Atomic Energy Commission, INTRODUCTIONRickets as a clinical entity was first reported in 1645 in a thesis by Whistler l ) entitled "De morbo puerili Anglorum quem patrio idiomate indigenae vocant, The Rickets". A detailed description of the disease followed 5 years later by Glison (1650). Almost two centuries later Guerin (1838) was probably the first to produce rickets in puppies and suggested that rickets resulted from a faulty diet. The curative effect of cod liver oil in clinical rickets was pointed out by Trousseau (1865). Hopkins in 1912 first suggested that rickets was due to a dietary deficiency and the same year Funk (1912) propounded the "vitamin hypothesis" according to which the existence of separate anti-beriberi, antiscurvy, anti-rachitic and anti-pellagra "vitamins" was postulated. Huldschinsky (1919) showed that rickets could be cured by artificial light no less than by direct sunlight. Steenbock and his co-workers, in 1924, deduced that ultraviolet rays activated some vitamin precursors in the skin of the body or in the food. Hess and Weinstock (1924) confirmed this shortly afterwards. One year later a crude cholesterol fraction was isolated from cod-liver-oil, by the same authors, and it was thought to be the "anti-rachitic provitamin". The vitamin itself was isolated, in a pure state, from the irradiation products of ergosterol by Askew et al. in 1930 and by Windhaus et al. in 1932. The vitamin was first named vitamin D or calciferol. Ergocalciferol was later adopted as its official name. Two calcemic sterols have been prepared in crystalline form, namely vitamin Dz or dihydrota...

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Section: Discussionmentioning

confidence: 84%

Section: )mentioning

confidence: 82%

Section: Percentage Of the Total Dry Weightmentioning

confidence: 99%

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Vitamin D and Skeletal Metabolism: Experimental Studies in the Rat

Sevastikoglou¹,

Ray²,

Hjertquist³

et al. 1970

Acta Orthopaedica Scandinavica

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“…When desired, hypertrophy of the parathyroids was achieved by placing the chicks on a diet deficient in calcium (AOAC low calcium rachitogenic diet, Cipera et al, 1960) for five days. One-day-old White Plymouth Rock chicks were procured and kept in temperature controlled laboratory cages.…”

Section: Methodsmentioning

confidence: 99%

Effects of Parathyroidectomy and of Administration of Parathormone on Serum Calcium in Immature Chicks ,

Cherian¹,

Cipera²

1968

Poultry Science

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Histologic observations and biochemical composition of rachitic cartilage with special reference to mucopolysaccharides

Howell

1965

Arthritis & Rheumatism

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Costal tissues were analyzed biochemically in respect to a profile of sulfated mucopolysaccharides from normal and rachitic calves which provided large samples of anatomically identifiable regions for biochemical analysis. Histologic distribution of these compounds was obtained through the use of x‐ray elemental analysis for sulfur. Distinctive differences between polysaccharide content of normal and rachitic tissues were found and calcification in vitro of the rachitic cartilage was demonstrated.

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COMPOSITION OF EPIPHYSEAL CARTILAGE: I. CHANGES IN HEXOSAMINE AND ACETONE EXTRACTABLE CONTENTS OF EPIPHYSEAL CARTILAGE OF RACHITIC CHICKS FOLLOWING ADMINISTRATION OF VITAMIN D_a

Cited by 10 publications

References 10 publications

Vitamin D and Skeletal Metabolism: Experimental Studies in the Rat

Vitamin D and Skeletal Metabolism: Experimental Studies in the Rat

Effects of Parathyroidectomy and of Administration of Parathormone on Serum Calcium in Immature Chicks ,

Histologic observations and biochemical composition of rachitic cartilage with special reference to mucopolysaccharides

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COMPOSITION OF EPIPHYSEAL CARTILAGE: I. CHANGES IN HEXOSAMINE AND ACETONE EXTRACTABLE CONTENTS OF EPIPHYSEAL CARTILAGE OF RACHITIC CHICKS FOLLOWING ADMINISTRATION OF VITAMIN Da

Cited by 10 publications

References 10 publications

Vitamin D and Skeletal Metabolism: Experimental Studies in the Rat

Vitamin D and Skeletal Metabolism: Experimental Studies in the Rat

Effects of Parathyroidectomy and of Administration of Parathormone on Serum Calcium in Immature Chicks ,

Histologic observations and biochemical composition of rachitic cartilage with special reference to mucopolysaccharides

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Product

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COMPOSITION OF EPIPHYSEAL CARTILAGE: I. CHANGES IN HEXOSAMINE AND ACETONE EXTRACTABLE CONTENTS OF EPIPHYSEAL CARTILAGE OF RACHITIC CHICKS FOLLOWING ADMINISTRATION OF VITAMIN D_a