Composition of a Chemopreventive Proanthocyanidin-Rich Fraction from Cranberry Fruits Responsible for the Inhibition of 12-<i>O</i>-Tetradecanoyl Phorbol-13-acetate (TPA)-Induced Ornithine Decarboxylase (ODC) Activity

Kandil, F. E.; Smith, M. A.; Rogers, Randy B.; Pépin, Marie-France; Song, Lynda L.; Pezzuto, John M.; Seigler, David S.

doi:10.1021/jf011136z

Cited by 78 publications

(67 citation statements)

References 31 publications

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“…Cranberry extracts containing PACs and other flavonoids reportedly inhibited ODC activity linked to cell proliferation in mouse epithelial (ME-308) cells [33]. Characterization of an active subfraction revealed the presence of dimers and oligomers of catechin/epicatechin, monomeric catechins, and quercetin glycosides.…”

Section: Antiproliferative Activity Of Polyphenolic Extractsmentioning

confidence: 97%

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Anticancer activities of cranberry phytochemicals: An update

Neto¹,

Amoroso²,

Liberty³

2008

Mol. Nutr. Food Res.

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Studies employing mainly in vitro tumor models show that extracts and compounds isolated from cranberry fruit (Vaccinium macrocarpon) inhibit the growth and proliferation of several types of tumor including breast, colon, prostate, and lung. Proanthocyanidin oligomers, flavonol and anthocyanin glycosides and triterpenoids are all likely contributors to the observed anticancer properties and may act in a complementary fashion to limit carcinogenesis. Possible chemopreventive mechanisms of action by cranberry phytochemicals include induction of apoptosis in tumor cells, reduced ornithine decarboxylase activity, decreased expression of matrix metalloproteinases associated with prostate tumor metastasis, and anti-inflammatory activities including inhibition of cyclooxygenases. A review of recent studies suggests a potential role for cranberry as a dietary chemopreventive and provides direction for future research.

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Section: Antiproliferative Activity Of Polyphenolic Extractsmentioning

confidence: 97%

“…Several studies of cranberry extracts with anticancer activities implicate the PACs as major contributors [20,33,34].…”

Section: Structure and Activity Of Cranberry Proanthocyanidinsmentioning

confidence: 99%

Anticancer activities of cranberry phytochemicals: An update

Neto¹,

Amoroso²,

Liberty³

2008

Mol. Nutr. Food Res.

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“…In 2002, a University of Illinois study revealed that extracts of whole cranberry containing PACs and other flavonoids inhibited ODC activity in mouse epithelial (ME-308) cells [45]. A subfraction also inhibited ODC in this cell line.…”

Section: Pacs: Structure and Activitymentioning

confidence: 99%

Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases

Neto

2007

Molecular Nutrition Food Res

393

265

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Growing evidence from tissue culture, animal, and clinical models suggests that the flavonoid-rich fruits of the North American cranberry and blueberry (Vaccinium spp.) have the potential ability to limit the development and severity of certain cancers and vascular diseases including atherosclerosis, ischemic stroke, and neurodegenerative diseases of aging. The fruits contain a variety of phytochemicals that could contribute to these protective effects, including flavonoids such as anthocyanins, flavonols, and proanthocyanidins; substituted cinnamic acids and stilbenes; and triterpenoids such as ursolic acid and its esters. Cranberry and blueberry constituents are likely to act by mechanisms that counteract oxidative stress, decrease inflammation, and modulate macromolecular interactions and expression of genes associated with disease processes. The evidence suggests a potential role for dietary cranberry and blueberry in the prevention of cancer and vascular diseases, justifying further research to determine how the bioavailability and metabolism of berry phytonutrients influence their activity in vivo.

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“…The K þ adduct produced a prominent ion attributed to a 2,5 X 0 cleavage unlike the other two adducts that gave an 3,5 A 2 fragment as the only prominent cross-ring cleavage (Kéki, Deák, & Zsuga, 2001). MALDI-TOF and FAB MS was used by Kandil et al (2002) to identify constituents, including several flavonoid glycosides from an extract of the American cranberry (Vaccinium macrocarpon) that were responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate-induced ornithine decarboxylase activity. Cyanidin 3-dimalonyl glucoside, detected in the aquatic plant hydrilla (Hydrilla verticillata L.f. Royle) by MALDI has not been detected in the surrounding water suggesting that this substance, suspected of being excreted, could be degraded by bacteria (Glomski et al, 2002).…”

Section: Glycosides From Plantsmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update covering the period 2001–2002

Harvey¹

2008

Mass Spectrometry Reviews

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This review is the second update of the original review on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates that was published in 1999. It covers fundamental aspects of the technique as applied to carbohydrates, fragmentation of carbohydrates, studies of specific carbohydrate types such as those from plant cell walls and those attached to proteins and lipids, studies of glycosyl-transferases and glycosidases, and studies where MALDI has been used to monitor products of chemical synthesis. Use of the technique shows a steady annual increase at the expense of older techniques such as FAB. There is an increasing emphasis on its use for examination of biological systems rather than on studies of fundamental aspects and method development and this is reflected by much of the work on applications appearing in tabular form.

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Composition of a Chemopreventive Proanthocyanidin-Rich Fraction from Cranberry Fruits Responsible for the Inhibition of 12-O-Tetradecanoyl Phorbol-13-acetate (TPA)-Induced Ornithine Decarboxylase (ODC) Activity

Cited by 78 publications

References 31 publications

Anticancer activities of cranberry phytochemicals: An update

Anticancer activities of cranberry phytochemicals: An update

Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update covering the period 2001–2002

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