Composition Fluctuations in Lipid Bilayers

Baoukina, Svetlana; Rozmanov, Dmitri; Tieleman, D. Peter

doi:10.1016/j.bpj.2017.10.009

Cited by 47 publications

(66 citation statements)

References 74 publications

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“…This clearly conrms that the signicant part of the hydrophilic atoms of the peptide conjugates is buried in the core region of the hydrophobic aromatic pyrene rings unlike the arrangements of lipids/surfactants in biological membranes/vesicles. [30][31][32][33] The hydrophilic peptide conjugates are stabilized by the intra-molecular hydrogen bonds between N-H and O as shown in the inset of Fig. 6C.…”

Section: Resultsmentioning

confidence: 99%

Unusual confinement properties of a water insoluble small peptide hydrogel

et al. 2019

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Section: Resultsmentioning

confidence: 99%

Unusual confinement properties of a water insoluble small peptide hydrogel

et al. 2019

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“…To finish with, a potentially important structural difference between domains below the demixing temperature Td and density fluctuations close to the critical point has recently been suggested through coarse-grained molecular dynamics [211]. Well below Td, there is a strong overlap between Lo domains in opposed leaflets (at least in planar geometry), which we have called registered domains above.…”

Section: General Discussion and Conclusionmentioning

confidence: 99%

A Rationale for Mesoscopic Domain Formation in Biomembranes

2018

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Cell plasma membranes display a dramatically rich structural complexity characterized by functional sub-wavelength domains with specific lipid and protein composition. Under favorable experimental conditions, patterned morphologies can also be observed in vitro on model systems such as supported membranes or lipid vesicles. Lipid mixtures separating in liquid-ordered and liquid-disordered phases below a demixing temperature play a pivotal role in this context. Protein-protein and protein-lipid interactions also contribute to membrane shaping by promoting small domains or clusters. Such phase separations displaying characteristic length-scales falling in-between the nanoscopic, molecular scale on the one hand and the macroscopic scale on the other hand, are named mesophases in soft condensed matter physics. In this review, we propose a classification of the diverse mechanisms leading to mesophase separation in biomembranes. We distinguish between mechanisms relying upon equilibrium thermodynamics and those involving out-of-equilibrium mechanisms, notably active membrane recycling. In equilibrium, we especially focus on the many mechanisms that dwell on an up-down symmetry breaking between the upper and lower bilayer leaflets. Symmetry breaking is an ubiquitous mechanism in condensed matter physics at the heart of several important phenomena. In the present case, it can be either spontaneous (domain buckling) or explicit, i.e., due to an external cause (global or local vesicle bending properties). Whenever possible, theoretical predictions and simulation results are confronted to experiments on model systems or living cells, which enables us to identify the most realistic mechanisms from a biological perspective.

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“…These membranes are usually described as lipid bilayers, associated with proteins and other components, e.g., polysaccharides [2]. Currently, many studies are carried out on membrane models, i.e., monolayers [3] or bilayers [4][5][6]. The main goal of developing artificial lipid membranes is to reproduce the natural functions and to understand the interaction between all the membrane components on the molecular level [7].…”

Section: Introductionmentioning

confidence: 99%

Equilibria in DPPC-Diosgenin and DPPC-Diosgenin Acetate Bilayer Lipid Membranes: Interfacial Tension and Microelectrophoretic Studies

et al. 2020

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Interactions between components of model lipid membranes (spherical lipid bilayers and liposomes) are investigated here. Parameters characterizing equilibria in the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-diosgenin (Dio) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-diosgenin acetate (DAc) membrane systems have been determined. The interfacial tension measurement of spherical lipid bilayers was based on the Young-Laplace’s equation using a homemade computer-controlled device. We assume a 1:1 complex in the DPPC-Dio and DPPC-DAc membrane systems. The parameters A 3 − 1 , the surface concentration of lipid membranes formed from these complexes, γ 3 , the interfacial tension of such membranes, and, K, the constant stability of these complexes were calculated. Microelectrophoresis was used for examinations of the surface charge density of lipid membranes. The values were obtained here from electrophoretic mobility data applying Smoluchowsky’s equation. The effect of pH (pH ranged of 2 to 10) on the electrolyte solution and the compositions of the membranes was analyzed. The obtained results indicate that the modification of DPPC membranes with both Dio and DAc causes changes in surface charge density values and shifts of the isoelectric point.

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Composition Fluctuations in Lipid Bilayers

Cited by 47 publications

References 74 publications

Unusual confinement properties of a water insoluble small peptide hydrogel

Unusual confinement properties of a water insoluble small peptide hydrogel

A Rationale for Mesoscopic Domain Formation in Biomembranes

Equilibria in DPPC-Diosgenin and DPPC-Diosgenin Acetate Bilayer Lipid Membranes: Interfacial Tension and Microelectrophoretic Studies

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