Composition and Structure of Gut Microbiome in Adolescents with Obesity and Different Breastfeeding Duration

Belkova, Natalia; Nemchenko, U. M.; Погодина, Анна; Feranchuk, Sergey; Romanitsa, A. I.; Новикова, Е. А.; Rychkova, L. V.

doi:10.1007/s10517-019-04617-7

Cited by 19 publications

(10 citation statements)

References 12 publications

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“…Center for Family Health and Human Reproduction Problems (Irkutsk, Russia) implemented a study of intestinal microbiomes of adolescents with normal body weight and obesity [17]. The study was approved by the Ethics Committee of the Scientific Center for Family Health and Human Reproduction Problems (protocol no.…”

Section: Brief Description Of Research Material the Scientificmentioning

confidence: 99%

The Ability of Taxonomic Identification of Bifidobacteria Based on the Variable Regions of 16S rRNA Gene

et al. 2020

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Bifidobacteria are considered key commensals of the human intestinal tract; they dominate the community in the earliest stages of life and are the first to respond to stress factors. The metasequencing of the V3-V4 16S rRNA fragments made it possible to identify 12 phylotypes of bifidobacteria in the gut microbiome of adolescents, which accounted for from 0.0001 to 0.9% of the total microbiome. A phylogenetic analysis of the obtained phylotypes was conducted; such species as B. angulatum, B. bifidum, B. longum, and B. animalis, as well as subspecies B. animalis subsp. lactis, were identified. The species of bifidobacteria excluded from identification by the V3-V4 variable regions were identified. The phylogenetic analysis of different variable regions and their combinations showed that a tree topology based on the V2 fragment is the most similar to a tree topology based on the complete gene.

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Section: Brief Description Of Research Material the Scientificmentioning

confidence: 99%

The Ability of Taxonomic Identification of Bifidobacteria Based on the Variable Regions of 16S rRNA Gene

et al. 2020

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“…The data files (reads in FASTQ format) were deposited at NCBI SRA as BioProject PRJNA604466. The datasets presented in this report are partly shown in the research article named “Composition and Structure of Gut Microbiome in Adolescents with Obesity and Different Breastfeeding Duration” [1] . The Illumina sequencer produced 4 209 582 paired-end reads in total.…”

Section: Data Descriptionmentioning

confidence: 99%

“…In the current datasets, we present 16S rDNA amplicon metasequencing of the gut microbiome of adolescents with normal weight, obesity, and obesity with irritable bowel syndrome (IBS) carried out using the Illumine platform. The datasets presented in this report are partly shown in the research article named “Composition and Structure of Gut Microbiome in Adolescents with Obesity and Different Breastfeeding Duration” [1] . The amplicon metasequencing data were deposited at NCBI SRA as BioProject PRJNA604466.…”

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confidence: 99%

Metagenomic 16S rDNA amplicon datasets from adolescents with normal weight, obesity, and obesity with irritable bowel syndrome from Eastern Siberia, Russia

et al. 2020

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Childhood obesity and its consequences are a significant public health problem worldwide. Gut microbiota has a potential role in the development of. In the current datasets, we present 16S rDNA amplicon metasequencing of the gut microbiome of adolescents with normal weight, obesity, and obesity with irritable bowel syndrome (IBS) carried out using the Illumine platform. The datasets presented in this report are partly shown in the research article named “Composition and Structure of Gut Microbiome in Adolescents with Obesity and Different Breastfeeding Duration” [1] . The amplicon metasequencing data were deposited at NCBI SRA as BioProject PRJNA604466. A total of 22 phyla, 34 classes, and 231 genera were revealed. Three groups of adolescents had 196 core amplicon sequence variant (ASV), whereas 45, 24, and 1 ASV were unique for adolescents with normal body weight, obesity, and obesity with IBS, respectively. The metagenomic data were first obtained for adolescents from Eastern Siberian, Russia. They have the potential for predictive analysis, which is crucial for understanding microbial community dynamics and their role in the development of the intestinal microbiome. Considering the recent focus on gut microbiota, new datasets are needed to determine the association between gut microbes and the weight of adolescents from previously unexplored regions such as Siberia, Russia.

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“…(7) Some studies showed that patients with obesity had an increase in the ratio of Firmicutes/Bacteroidetes, which was associated with an enhanced capacity to derive energy from food due to a more active breakdown of carbohydrate complexes. (61,62) Even though the data on the content of microbiota in patients with IBS is controversial, these patients have a similar type of dysbiosis. (63) Saulnier et al (64) showed that the content of microbiota correlated with the severity and rate of abdominal pain in children with IBS.…”

Section: Obesity and Fbds In Children: Possible Mechanisms Of Associamentioning

confidence: 99%

Functional Bowel Disorders and Obesity in Children: State of the Problem

Погодина¹,

Romanitsa²,

Рычкова³

2020

IJBM

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Obesity and functional bowel disorders (FBDs) are often observed in children and have common risk factors. The present review aimed to summarize the published data on the association between obesity and FBDs in children and a discussion of possible pathophysiological mechanisms that may be involved. Published data indicates that obesity and FBDs could be associated conditions. There is substantial evidence that obesity in children is associated with constipation. However, it should be noted that there were few studies in this direction, and those studies were heterogeneous in both the composition of participants and studied diagnostic criteria, and in the majority of cases, they were not adjusted for potential confounders. The association between obesity and FBDs can be explored through diet, peculiarities of eating behavior, and psychological factors. The most promising direction in the study could be the study of the GM, the changes in which can contribute to the development of immune dysfunctions of the bowel, chronic low-grade inflammation, increased colonic permeability, motility disturbances, and visceral hypersensitivity. The studies in this area can provide important data for developing a strategy of treatment and prevention of both groups of diseases.

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Composition and Structure of Gut Microbiome in Adolescents with Obesity and Different Breastfeeding Duration

Cited by 19 publications

References 12 publications

The Ability of Taxonomic Identification of Bifidobacteria Based on the Variable Regions of 16S rRNA Gene

The Ability of Taxonomic Identification of Bifidobacteria Based on the Variable Regions of 16S rRNA Gene

Metagenomic 16S rDNA amplicon datasets from adolescents with normal weight, obesity, and obesity with irritable bowel syndrome from Eastern Siberia, Russia

Functional Bowel Disorders and Obesity in Children: State of the Problem

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