Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

Murphy, Eileen F.; Cotter, Paul D.; Healy, Selena; Marques, Tatiana M.; O'Sullivan, Órla; Fouhy, Fiona; Clarke, Siobhan F.; O’Toole, Paul W.; Quigley, Eamonn M.M.; Stanton, Catherine; Ross, R. Paul; O’Doherty, Robert M.; Shanahan, Fergus

doi:10.1136/gut.2010.215665

Cited by 821 publications

(598 citation statements)

References 49 publications

Supporting

Mentioning

508

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, they also reported an increase in Fiaf levels in the obese mice, contradicting the mechanistic fi ndings described previously ( 5 ). Using an ob / ob mouse model fed low-fat and high-fat diets and compared with wild-type mice, Murphy et al ( 21 ) found an increased Firmicutes / Bacteroidetes ratio as previously described, but determined that the compositional changes were primarily the result of the high-fat diet rather than genetic obesity. Finally, results obtained from a mouse model with a humanized gut microbiome indicate that the gut microbes undergo a rapid shift in only a single day aft er switching from a low-fat, plant polysaccharide -rich diet to a high-fat, high-sugar, " Western " diet ( 22 ).…”

confidence: 52%

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

DiBaise¹,

Frank²,

Mathur³

2012

Am J Gastroenterol Suppl

124

View full text Add to dashboard Cite

confidence: 52%

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

DiBaise¹,

Frank²,

Mathur³

2012

Am J Gastroenterol Suppl

124

View full text Add to dashboard Cite

“…The intake of HFD has been shown to negatively alter the gut microbiota [50]. Gut dysbiosis has been linked with endotoxin-mediated chronic disease in mouse models [51,52].…”

Section: Discussionmentioning

confidence: 99%

Dietary Milk Sphingomyelin Reduces Systemic Inflammation in Diet-Induced Obese Mice and Inhibits LPS Activity in Macrophages

et al. 2017

View full text Add to dashboard Cite

High-fat diets (HFD) increase lipopolysaccharide (LPS) activity in the blood and may contribute to systemic inflammation with obesity. We hypothesized that dietary milk sphingomyelin (SM), which reduces lipid absorption and colitis in mice, would reduce inflammation and be mediated through effects on gut health and LPS activity. C57BL/6J mice were fed high-fat, high-cholesterol diets (HFD, n = 14) or the same diets with milk SM (HFD-MSM, 0.1% by weight, n = 14) for 10 weeks. HFD-MSM significantly reduced serum inflammatory markers and tended to lower serum LPS (p = 0.08) compared to HFD. Gene expression related to gut barrier function and macrophage inflammation were largely unchanged in colon and mesenteric adipose tissues. Cecal gut microbiota composition showed greater abundance of Acetatifactor genus in mice fed milk SM, but minimal changes in other taxa. Milk SM significantly attenuated the effect of LPS on pro-inflammatory gene expression in RAW264.7 macrophages. Milk SM lost its effects when hydrolysis was blocked, while long-chain ceramides and sphingosine, but not dihydroceramides, were anti-inflammatory. Our data suggest that dietary milk SM may be effective in reducing systemic inflammation through inhibition of LPS activity and that hydrolytic products of milk SM are important for these effects.

show abstract

“…Some studies have shown that obese people have an increased abundance of Firmicutes in the gut microbiota compared with lean people (8,9). The mouse gut microbiota is also responsive to increased energy intake, with an increased abundance of Firmicutes and reduced abundance of Bacteroidetes (10)(11)(12). In addition, a number of research groups have reported that the supplementation with prebiotics and/or probiotics tends to increase the abundance of Bifidobacterium in humans and animals (13)(14)(15)(16).…”

mentioning

confidence: 99%

“…Total bacterial cell numbers in 1 g of human feces is estimated at ~10 11 -10 12 , and the dominant bacterial phyla of the human gut microbiota are the Firmicutes, Bacteroidetes, and Actinobacteria with a lower relative abundance of Verrucomicrobia and Proteobacteria (1,2). The composition of gut microbiota has been shown to vary with clinical conditions such as type 2 diabetes, inflammatory bowel disease, nonalcoholic fatty disease, and allergy (3)(4)(5)(6).…”

mentioning

confidence: 99%

The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women

Seura

Yoshino

Fukuwatari

2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

Summary Recent studies have shown that dietary content affects the health of the host by changing the gut microbiota. However, little is known about the association of microbiota composition with habitual diet in Japanese people. Here, we aimed to clarify the relationship between the fecal microbiota and habitual dietary intake of micronutrients, macronutrients and food groups in healthy young Japanese women. Analysis of fecal microbiota was performed by the terminal restriction fragment length polymorphism (T-RFLP) method, and a dietary survey was conducted over three consecutive days using a weighed food record method. T-RFLP pattern analysis divided the subjects into two clusters, where cluster A group had a high relative abundance of Bacteroides and Clostridium cluster IV, and cluster B group had a high relative abundance of Bifidobacterium and Lactobacillales. Cluster A group also had lower intakes of iron and vitamin K and higher intakes of mushrooms and snacks than cluster B group. Analysis of Spearman rank correlations found several significant relationships between fecal microbiota and intake of nutrients and food groups. Bifidobacterium was correlated with iron intake, and Clostridium cluster XI was negatively correlated with intakes of cholesterol and eggs. These results suggest that dietary habits may strongly affect Bifidobacterium, Bacteroides and Clostridium abundance in the gut microbiota of young Japanese women. This is the first study to show relationships between fecal microbiota and habitual dietary intake in Japanese people. Accumulation of results from similar studies will help to elucidate the relationships between dietary intake and diseases in Japanese people.

show abstract

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

Cited by 821 publications

References 49 publications

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

Dietary Milk Sphingomyelin Reduces Systemic Inflammation in Diet-Induced Obese Mice and Inhibits LPS Activity in Macrophages

The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women

Contact Info

Product

Resources

About