Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe

Sibanda, S.; Chigwada, Grace; Poole, Melvin; Gwebu, Ephraim T.; Noletto, Joseph A.; Schmidt, Jennifer M.; Rea, Angela I.; Setzer, William N.

doi:10.1016/j.jep.2004.02.010

Cited by 104 publications

(46 citation statements)

References 28 publications

(24 reference statements)

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“…Sibanda et al (2004) demonstrated that linalool is a compound with some antimicrobial activity, but not cytotoxic against SK-MEL-28, MDA-MB-231, MCF7, PC-3 and Hs 578T cells. However, Tatman & Mo (2002) verified that both linalool and á-pinene present cytotoxic activity against murine B16 melanoma and human HL-60 leukemia cells.…”

Section: Discussionmentioning

confidence: 99%

“…leaves was determined (Moura et al, 2006). Despite not being preponderant, the oil analyses showed that among its numerous constituents, there are some components described in literature as cytotoxic substances against tumoral cells, such as β-caryophyllene (5.9%), β-elemene (3.1%), δ -elemene (1.6%), α-humulene (2.3%) (Duh et al, 1999;Legault et al, 2003;Sibanda et al, 2004;Sylvestre et al, 2005;Stravi et al, 2005;Tatman and Mo, 2002;Wang et al, 2005;Sylvestre et al, 2006;Hou et al, 2006;Tao et al, 2006;Xiao et al, 2006. Some other components with no or low antitumoral activity were also found in this species, eg sphathulenol (3.8%), á-pinene (6.4%), linalool (0.5%), myrcene (0.6%) (Fullas et al, 1994;Tatman & Mo, 2002;Stavri et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

2007

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Zanthoxylum rhoifolium Lam is a plant popularly used as antimicrobial, for malaria and inflammatory treatment. The essential oil of Z. rhoifolium was extracted and its cytotoxic effects against HeLa (human cervical carcinoma), A-549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), Vero (monkey kidney) cell lines and mice macrophages were evaluated. Some of the terpenes of its essential oil (β-caryophyllene, α-humulene, α-pinene, myrcene and linalool) were also tested to verify their possible influence in the oil cytotoxic activity. The results obtained permitted to confirm that the essential oil is cytotoxic against tumoral cells (CD 50 = 82.3, 90.7 and 113.6 µg/ml for A-549, HeLa e HT-29 cell lines, respectively), while it did not show cytotoxicity against non-tumoral cells (Vero and mice macrophages). Thus, the essential oil from Z. rhoifolium leaves seems to present a possible therapeuthic role due to its selective cytotoxic activity against tumoral cell lines. KEYWORDSZanthoxylum, Essential oil, cytotoxicity, β-caryophyllene, α-humulene Avaliação citotóxica do óleo volátil extraído das folhas do

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

2007

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“…The cytotoxicity of eugenol to human HFF fibroblasts and human HepG2 hepatoma cells was increased somewhat in the presence of a hepatic S-9 microsomal fraction from Aroclor-induced rats or hamsters (35). On the other hand, terpinen-4-ol did not cause any cytotoxic effect on SK-MEL-28, MDA-MB-231, MCF7, 5637, and PC-3 human tumor cells but had detrimental effects on Hs578T cells (36,37). The IC 50 concentration of this component was found to be higher than 100 µmol for A549 and DLD-1 cell lines (38).…”

Section: Cytotoxic and Cytoprotective Effects Of Eugenol Eucalyptolmentioning

confidence: 96%

Membrane and DNA Damaging/Protective Effects of Eugenol, Eucalyptol, Terpinen-4-ol and Camphor at Various Concentrations on Parental and Drug Resistant H1299 Cells

Özkan¹

2013

Turk J Biol

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Eugenol, eucalyptol, and camphor, used as flavor agents in cosmetic and food products, have both prooxidant and antioxidant activities. To clarify the mechanisms of their cytotoxic effect and the factors affecting their antioxidant/prooxidant activities, we investigated cell membrane and DNA damage/protective effects induced by eugenol, eucalyptol, terpinen-4-ol, and camphor in parental and drug-resistant human lung cancer cell lines. The parental cells were found approximately 3, 6, and 8 times more sensitive to camphor cytotoxicity than drug-resistant cells at 24, 48, and 72 h respectively. The cytotoxic activity for both cell types was found to be in the order of camphor, eugenol, terpinen-4-ol, and eucalyptol, depending on their concentrations. Malondialdehyde and 8-hydroxy deoxyguanosine levels were also increased as a result of membrane and DNA damage in both cell lines exposed to the highest concentration of these test components. On the other hand, eugenol, eucalyptol, terpinen-4-ol, and camphor protected the cells against H 2 O 2 -induced cytotoxicity, membrane damage, and DNA damage when the cells were incubated with these test components at lower concentrations (< IC 50 ) before H 2 O 2 treatment. These findings suggest that eugenol, eucalyptol, terpinen-4-ol, and camphor exhibit membrane and DNA protective/damaging effects changing in a manner dependent upon concentration, cell type, and time.

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“…Further identification confirmations were made referring to RI data generated from a series of known standards of n-alkanes mixture (C 8 to C 26 ) [29] and to those previously reported in the literature [30][31][32].…”

Section: Volatile Compounds Identificationmentioning

confidence: 99%

Essential oil of <i>Thymus vulgaris</i> L. and <i>Rosmarinus officinalis</i> L.: Gas chromatography-mass spectrometry analysis, cytotoxicity and antioxidant properties and antibacterial activities against foodborne pathogens

Miladi¹,

Slama²,

Mili³

et al. 2013

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The essential oil composition of Thymus vulgaris L. and Rosmarinus officinalis L. endemic to France were determined by GC and GC-MS. Oils were assessed for their cytotoxic, antioxidant and antimicrobial activity. 31 and 37 different compounds were identified representing 99.64% and 99.38% of the thyme and rosemary oils respectively, where oxygenated monoterpenes constituted the main chemical class. Thymol (41.33%) and 1.8-cineole (24.10%) were identified as the main constituents of T. vulgaris L. and R. officinalis L., respectively. Essential oils (EOs) of selected plant species were evaluated for their in vitro cytotoxicity against the human lung adenocarcinoma epithelial cell line (A549). Cytotoxicity was measured using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphynyltetrazolium bromide] colorimetric assay. Dose-dependent studies revealed IC 50 of 8.50 ± 0.01 µg/mL and 10.50 ± 0.01 µg/mL after 72 h on the A549 cells for R. officinalis L. and T. vulgaris L., respectively. Antioxidant activity was determined using a quantitative DPPH (1,1-diphenyl-2-picryl hydrazyl) assay. Thymus and rosemary EOs exhibited effective radical scavenging capacity with 50% inhibitory concentration (IC 50 ) of 437 ± 5.46 µg/mL and 189 ± 2.38 µg/mL respectively and therefore acts as a natural antioxidant agent. The antimicrobial activity of these species has also been studied against several foodborne pathogens and food isolated Salmonella spp. including S. enteritidis of significant importance. According to the results, T. vulgaris L. showed higher bactericidal effect than those from R. officinalis L. These results suggest that the essential oil from T. vulgaris L. and R. officinalis L. have potential to be used as a natural cytotoxic, antioxidant and antimicrobial agent in food processing.

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Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe

Cited by 104 publications

References 28 publications

Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

Membrane and DNA Damaging/Protective Effects of Eugenol, Eucalyptol, Terpinen-4-ol and Camphor at Various Concentrations on Parental and Drug Resistant H1299 Cells

Essential oil of <i>Thymus vulgaris</i> L. and <i>Rosmarinus officinalis</i> L.: Gas chromatography-mass spectrometry analysis, cytotoxicity and antioxidant properties and antibacterial activities against foodborne pathogens

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Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe

Cited by 104 publications

References 28 publications

Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

Cytotoxic evaluation of essential oil from Zanthoxylum rhoifolium Lam. leaves

Membrane and DNA Damaging/Protective Effects of Eugenol, Eucalyptol, Terpinen-4-ol and Camphor at Various Concentrations on Parental and Drug Resistant H1299 Cells

Essential oil of &lt;i&gt;Thymus vulgaris&lt;/i&gt; L. and &lt;i&gt;Rosmarinus officinalis&lt;/i&gt; L.: Gas chromatography-mass spectrometry analysis, cytotoxicity and antioxidant properties and antibacterial activities against foodborne pathogens

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Essential oil of <i>Thymus vulgaris</i> L. and <i>Rosmarinus officinalis</i> L.: Gas chromatography-mass spectrometry analysis, cytotoxicity and antioxidant properties and antibacterial activities against foodborne pathogens