Composition and Antifungal Activity of the Essential Oil of Solidago chilensis

Vila, Roser; Mundina, Marisa; Tomi, Félix; Furlán, Ricardo L. E.; Zacchino, Susana; Casanova, Joseph; Cañigueral, Salvador

doi:10.1055/s-2002-20253

Cited by 41 publications

(31 citation statements)

References 6 publications

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“…A análise por meio de CLAE-UV-PDA permitiu a caracterização de 6 flavonoides: através do seu tempo de retenção na metodologia utilizada, dados da literatura e espectro no UV, todos também já descritos para o gênero (FIGURAS 2 e 3; TABELA 1) (APÁTI et al, 2002;APÁTI, 2003;JIANG, HUANG e QIN, 2006;LORENZI e MATOS, 2002;TORRES, AKISUE e ROQUE 1985;VILA et al, 2002).…”

Section: Resultsunclassified

“…Nessa lista, consta a espécie Solidago chilensis (=Solidago microglossa), uma espécie nativa da América do Sul, encontrada na região sudeste do Brasil, que também cresce em outros países (Argentina). Seus rizomas frescos são utilizados na medicina tradicional como diurético, estimulante do apetite e anti-helmíntico (HIRSCHMANN, 1988;VILA et al, 2002;LORENZI e MATOS, 2002), enquanto suas partes aéreas são empregadas como anti-inflamatório (SANTOS e REIS, 1998;RAZMILIC e SCHMEDA-HIRSCHMAN, 2000).…”

Section: Introdução Em 2008 O Ministério Da Saúde Criou a Relação Naunclassified

“…(JIANG, HUANG e QIN, 2006;TORI et al, 1999;LU et al, 1995). Entre os constituintes químicos da espécie Solidago chilensis encontram-se flavonoides derivados da quercetina (como a quercitrina e a rutina) (TORRES, AKISUE e ROQUE, 1987;SABIR et al, 2012;GASTALDO, 2013) e do kaempferol (GRIZA, 2007), terpenos, principalmente diterpenos labdânicos e clerodânicos (GOSWAMI et al, 1984), como a solidagenona e, além de mono, sesqui e diterpenos presentes no óleo essencial de S. chilensis, como: β-cubebeno, germacreno-B e pumilóxido (GRESSLER et al, 2003;DIAS, 2001;VILA et al, 2002) e substâncias acetiladas (ANTHONSEN et al, 1969;ANTHONSEN e BERGLAND, 1973;RAZMILIC e SCHMEDA-HIRSCHMAN, 2000;KASALI et al, 2002;VALVERDE, OLIVEIRA e SOUZA, 2012 Flavonoides derivados da quercetina são relatados como componentes principais dos extratos alcoólicos e hidroalcoólicos de espécies do gênero Solidago, corroborando para o emprego tradicional da espécie e de seus extratos (APÁTI et al, 2002;APÁTI, 2003).…”

Section: Introdução Em 2008 O Ministério Da Saúde Criou a Relação Naunclassified

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Caracterização de flavonoides por CLAE-UV-PDA em tintura de inflorescências de Solidago chilensis Meyen cultivada em Itaipava (RJ)

et al. 2017

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ResumoSolidago chilensis (=Solidago microglossa) é uma espécie amplamente utilizada pela população e constante da lista RENISUS de espécies medicinais utilizadas nos serviços de saúde. Essa espécie é utilizada em desordens inflamatórias em substituição à Arnica montana. Flavonoides agem como anti-inflamatórios por diferentes mecanismos de ação, inibindo enzimas como a fosfolipase, lipoxigenase ou cicloxigenases.Flavonoides derivados da quercetina são inibidores da COX-2 e da NOS e diminuem a adesão de células inflamatórias ao endotélio vascular, sendo os principais componentes dos extratos alcoólicos e hidroalcoólicos de plantas do gênero Solidago. Este trabalho busca contribuir para o atendimento à saúde pública e viabilizar o desenvolvimento sustentável econômico, através da fitoterapia; para a conservação ambiental, pela utilização de inflorescências e, socialmente, visando a inclusão de novo medicamento fitoterápico no SUS.Portanto, são necessárias a validação, a padronização e a garantia da segurança e eficácia das tinturas, determinando seus marcadores químicos e/ou biológicos. A tintura de inflorescências de S. chilensis foi produzida de acordo com a Farmacopeia Brasileira IV (FB 4) e analisada por CLAE-UV-PDA. As substâncias eluídas foram analisadas quanto ao tempo de retenção, sua absorção em UV à 310nm e dados da literatura.Os flavonoides aqui caracterizados são amplamente descritos para o gênero Solidago e Solidago chilensis e, possivelmente, estão relacionados às ações farmacológicas observadas para essa espécie.Palavras-chave: Solidago chilensis. Tintura. Desenvolvimento sustentável. Flavonoides. CLAE. SUS. AbstractIn 2008, the RENISUS list created was considering the used medicinal species in the health services.Solidago chilensis (=Solidago microglossa) species was in this list and it is used instead of an exogenous

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Section: Resultsunclassified

Section: Introdução Em 2008 O Ministério Da Saúde Criou a Relação Naunclassified

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Caracterização de flavonoides por CLAE-UV-PDA em tintura de inflorescências de Solidago chilensis Meyen cultivada em Itaipava (RJ)

et al. 2017

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“…However, the chemotaxonomic information indicated that all labdanes from Solidago genus belong to the normal series 5,19,20) and by analogy, compound 1 could be assigned to this series. Therefore, the structure of compound 1 was identified as 9a,16x-dihydroxy-6-oxo-7,13-labdadien-15,16-olide.…”

Section: Resultsmentioning

confidence: 99%

A New Labdane Diterpene from the Flowers of Solidago canadensis

et al. 2008

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Solidago canadensis L. is an Asteraceae widely distributed across North America, occurring in almost every state of the U.S.A. and throughout Canada. Numerous interesting secondary metabolites such as: flavonoids, phenolic acids and glucosides, polysaccharides, diterpenes, triterpenoid saponosides, tannins and essential oils 1) were reported for the genus Solidago. Previous phytochemical studies of S. canadensis have led to the isolation of flavonoids, 2,3) phenolic acids, 4) sesquiterpenes, 5) diterpenes 6,7) and saponins.7) The flowers of S. canadensis were used in traditional Amerindian medicine as an analgesic, 8) burns and ulcers treatment, 9) febrifuge, 10) gastrointestinal 11,12) and liver 11) aids. In spite of the widespread use of S. canadensis, few investigations were carried out on its bioactive secondary metabolites.Fractionation of the flower extracts of Solidago canadensis resulted in the isolation of a new diterpene, 9a,16x-dihydroxy-6-oxo-7,13-labdadien-15,16-olide (solicanolide, 1) and six known compounds identified as quercetin (2), 3-O-caffeoylquinic acid (neochlorogenic acid) (3), 5-O-caffeoylquinic acid (chlorogenic acid) (4), 4,5-di-O-caffeoylquinic acid (5), 3,5-di-O-caffeoylquinic acid (6) and 3,4-di-O-caffeoylquinic acid (7). To our knowledge, compound 7 was isolated for the first time in S. canadensis. This work describes the isolation of compounds 1-7 and the structure elucidation of a new compound identified as compound 1. The cytotoxicity of solicanolide (1) was also investigated in this paper. ExperimentalGeneral Experimental Procedures NMR spectra were recorded in methanol-d 4 on a Bruker Avance 400 spectrometer (5 mm QNP with Z-gradient probe) operating at 400.13 MHz ( 1 H) or 100.61 MHz ( 13 C). Chemical shifts were referenced relative to the corresponding residual solvent signals (d H/C 3.31/49.0 ppm, respectively). The accurate mass determination was carried out with an Applied Biosystems QSTAR XL Hybrid LC/MS/MS system. Optical rotation was obtained on a Jasco DIP-360 digital polarimeter. Analytical HPLC-DAD-MS analysis were performed on an Agilent 1100 series HPLC-DAD-MS system. A Zorbax ODS C18 column (5 mm, 150ϫ4.6 mm) maintained at 25°C was utilised. The flow rate was 1 ml/min. Agilent G1315B diode array detector was used for UV detection. The UV spectra were recorded from 190 to 400 nm. An Agilent mass selective detector (VL model) equipped with an atmospheric chemical ionisation source (APCI) was employed for MS detection. All mass spectra were acquired in the negative ion mode. The full scan mass spectrum was recorded over the range of m/z 100-1000. Temperature of the drying gas (N 2 ) was 350°C with a gas flow rate of 10 l/min and a nebulizing pressure of 40 psi. The ionisation voltage was 4000 V and the corona current was 15 mA. All HPLC separations were performed on a preparative Agilent 1100 series (Agilent Technologies Canada Inc.) with a ZORBAX ODS column C18 (2.1ϫ25 cm; 7 mm) at a flow rate of 16 ml/min. Compounds were detected by UV absorption at 254 nm. For all...

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“…The presence of the quercitin glycosylated flavonoid, tannins, saponins, resins, inulin, rutin, quinic acid, caffeic acid, ramnosides, quercetin and glycosides reduce the fragility of blood vessels (Lorenzi & Matos, 2002). Vila et al (2002) mention that the oil extracted from leaves and fruits has antifungal properties.…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants used in Rondônia, Western Amazon, Brazil

Santos

Lima

Oliveira

2014

Rev. bras. plantas med.

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ABSTRACT:This study refers to the use of medicinal plants by populations in the Western Amazon and provides information that can be used in phytochemical studies. It draws upon the traditional knowledge regarding the use of medicinal plants in five regions of the state of Rondônia, in the Brazilian Amazon, focusing on native species. The field research was carried out in five municipalities of the state of Rondônia: Ariquemes, Buritis, Candeias do Jamari, Cujubim and Itapoa do Oeste, characterized by primary economic sectors: agriculture, cattle farming, plant extraction and mineral exploration. Structured interviews were applied to 227 persons chosen because of their prestige in the communities in relation to the knowledge and use of medicinal plants, identifying the therapeutic purpose, parts of the plant used and methods of preparation. The species were taxonomically identified. The ethnobotanic knowledge (inferred by the number of uses of medicinal plants per person) was correlated with the Brazilian region of origin, age, and gender of the interviewees. According to the collected data, 34 botanical families and 53 native species were identified. Of the 53 species, only 7 occur exclusively in the Amazon Forest: Theobroma grandiflorum (Willd. ex Spreng.) K. Schum., Psidium densicomum Mart. ex DC, Piper cavalcantei Yunck., Pilocarpus microphyllus Stapf ex Wardlew., Euterpe oleracea Mart., Croton cajucara Benth., Baccharis altimontana G. Heiden. The most common disorders treated with the plants were kidney problems, influenza, generalized infections and inflammations, malaria and high blood pressure. Leaves were the most used parts in preparations. Barks, fruits, roots, flowers, stems, seeds, oils, buds, tubercles, and rhizomes were also mentioned. Thirteen forms of preparations were recorded, and infusion and decoction were the most used. Syrups, juices, flour, sap, oil and parts of the plant blended with milk, honey and coffee or flamed, macerated and in the form of poultice, were also found. Persons from the Southeast region had more information compared with persons from the other regions; persons in the age groups between 50-59, 60-69 and 70-79 had more information in comparison with the other age groups; and the female interviewees mentioned significantly more uses of medicinal plants than the male ones. The relatively small number of native Amazon species identified can be the result of the loss of knowledge about medicinal plants in the Amazon because of internal migration, extinction of local indigenous groups, increasing urbanization and consequent globalization of the lifestyles. Keywords: Ethnobotany, Phytotherapy, Traditional Medicine.RESUMO: Plantas medicinais usadas em Rondônia, Amazônia Ocidental, Brasil. Este estudo se refere ao uso de plantas medicinais por populações da Amazônia Ocidental, fornece informações passíveis de utilização em estudos fitoquímicos e resgata o conhecimento tradicional a respeito do uso de plantas medicinais em cinco regiões do estado de Rondônia na Amazônia Brasileira...

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Composition and Antifungal Activity of the Essential Oil of Solidago chilensis

Cited by 41 publications

References 6 publications

Caracterização de flavonoides por CLAE-UV-PDA em tintura de inflorescências de Solidago chilensis Meyen cultivada em Itaipava (RJ)

Caracterização de flavonoides por CLAE-UV-PDA em tintura de inflorescências de Solidago chilensis Meyen cultivada em Itaipava (RJ)

A New Labdane Diterpene from the Flowers of Solidago canadensis

Medicinal plants used in Rondônia, Western Amazon, Brazil

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