Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L.

Khlifi, Daycem; Sghaier, Rabiaa M.; Amouri, Sameh; Laouini, Dhafer; Hamdi, Moktar; Bouajila, Jalloul

doi:10.1016/j.fct.2013.01.004

Cited by 161 publications

(88 citation statements)

References 42 publications

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“…The discrepancies between our results and those of Khlifi et al (2013) may be due to the differences in the concentration of the used plant extracts. In our study, we used extracts with higher concentrations than those used by Khlifi et al (2013).…”

Section: Discussioncontrasting

confidence: 95%

“…Our findings are consistent with those of Singh et al (2011) who showed that the ethanolic extracts of A. annua from Chinese and Brazilian origins were cytotoxic to human leukocyte cultures. On the other hand, Khlifi et al (2013) found that the methanolic extract of A. herba-alba showed no toxicity against human blood mononuclear cell cultures. The discrepancies between our results and those of Khlifi et al (2013) may be due to the differences in the concentration of the used plant extracts.…”

Section: Discussionmentioning

confidence: 98%

“…On the other hand, Khlifi et al (2013) found that the methanolic extract of A. herba-alba showed no toxicity against human blood mononuclear cell cultures. The discrepancies between our results and those of Khlifi et al (2013) may be due to the differences in the concentration of the used plant extracts. In our study, we used extracts with higher concentrations than those used by Khlifi et al (2013).…”

Section: Discussionmentioning

confidence: 98%

“…Finally, the ethanolic extract of A. herba-alba reduced the viability of HCT116 colon cancer cells in a dose and time dependent manner (Lupidi et al 2011), and the methanolic extract of this plant showed growth inhibitory effect on RT112 (bladder), Hep2 (larynx), and K562 (leukemia) cell lines in a dose dependent manner (Khlifi et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In the first study, Lupidi et al (2011) showed that the exposure of a cell line of human colon cancer to the ethanolic extract of the plant decreased cell viability, caused DNA damage, and induced apoptosis. In the other study, Khlifi et al (2013) demonstrated that the methanolic extracts of A. herba-alba had cytotoxic effect against three human cancer cell lines: bladder carcinoma, laryngeal carcinoma, and myelogenous leukemia. In contrast, the plant extract did not show any cytotoxicity against the normal peripheral blood mononuclear cells.…”

Section: Introductionmentioning

confidence: 94%

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Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Abderrahman

Shbailat

2014

Caryologia

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Artemisia herba-alba is a medicinal plant that is commonly used in folk remedies in the Middle East. Despite its wide use, little is known about whether or not it is genotoxic and/or cytotoxic to mammalian cells. Here we investigated the genotoxic and cytotoxic effects of the ethanolic plant extract on mice cells at different dose concentrations (125, 250, 375, and 500 μg ml ) and for different exposure times (12, 24, 48, and 72 h). We found that at all exposure times, treatment with high dose concentrations (375 and 500 μg ml ) of A. herba-alba extract significantly reduced cell division in mice bone marrow cells compared to that in the control cells. Also, it induced sister chromatid exchanges and micronuclei formation in bone marrow and peripheral blood cells, respectively. Moreover, high dose concentrations significantly reduced cell viability in bone marrow cell cultures compared to that in the controls. The IC 50 values were 484.38, 513.33, and 490.39 μg ml −1 after 24, 48, and 72 h of exposure, respectively. Our findings reveal that A. herba-alba extract has both genotoxic and cytotoxic effects on mammalian cells, particularly at high concentrations. Therefore, we suggest that the plant extract should not be used at high concentrations in folk medicine.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Abderrahman

Shbailat

2014

Caryologia

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Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Tshikhudo,

Mabhaudhi,

Koorbanally

et al. 2024

Chemistry & Biodiversity

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This comprehensive review is designed to evaluate the anticancer properties of β‐carbolines derived from medicinal plants, with the ultimate goal of assessing their suitability and potential in cancer treatment, management, and prevention. An exhaustive literature survey was conducted on a wide array of β‐carbolines including, but not limited to, harmaline, harmine, harmicine, harman, harmol, harmalol, pinoline, tetrahydroharmine, tryptoline, cordysinin C, cordysinin D, norharmane, and perlolyrine. Various analytical techniques were employed to identify and screen these compounds, followed by a detailed analysis of their anticancer mechanisms. Natural β‐carbolines such as harmaline and harmine have shown promising inhibitory effects on the growth of cancer cells, as evidenced by multiple in vitro and in vivo studies. Synthetically derived β‐carbolines also displayed noteworthy anticancer, neuroprotective, and cognitive‐enhancing effects. The current body of research emphasizes the potential of β‐carbolines as a unique source of bioactive compounds for cancer treatment. The diverse range of β‐carbolines derived from medicinal plants can offer valuable insights into the development of new therapeutic strategies for cancer management and prevention.

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Incorporation of fresh leaves of wormwood (Artemisia herba alba) and/or rosemary (Rosmarinus officinalis) in the diet of rams: Effect on testicular function, sexual behavior, and blood parameters

Khnissi

Bomboi

Khémiri

et al. 2023

Food Science & Nutrition

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This study aimed to investigate the effect of wormwood and rosemary supplementation on some reproductive traits of Barbarine rams. The experiment lasted 2 months. Twenty‐four adult rams were divided into four groups (n = 6) balanced for the weight (53.3 ± 1.2 kg body weight [BW] ± SD). All rams received 1200 g of straw and 600 g of barley. Control rams (C) without aromatic medicinal plant (AMP), while experimental rams received 20 g of fresh rosemary leaves (R), 20 g of fresh wormwood leaves (A), and 10 g of fresh rosemary leaves plus 10 g of fresh wormwood leaves (RA). The results revealed that the live weight of all rams increased (p < .05) in the RA group compared to the C, A, and R groups. Scrotal circumference increased in the R rams when compared to the controls rams (p < .05). For sperm parameters we showed that the A rams had higher sperm concentrations (p < .05). But, the sperm volume decreased in the R rams (p > .05). However, when the rams received rosemary plus wormwood, their sperm volume increased (p > .05). The sperm mass motility was higher for the A, R and AR rams in comparison to the C rams (p = .05). On the other hand, biochemical analysis of the seminal fluid showed no effect of diets on calcium and total proteins concentration. But the measurement of glucose and seminal insulin showed a decrease (p < .05) in these two biochemical markers in group A rams and a decrease (p < .05) in insulin without modification of the glucose concentration in R rams. Blood glucose and insulin decreased in the animals on AMP diet compared to the other groups (p < .05) while aspartate aminotransferase (AST) increased (p < .05). Rosemary leaves (R and RA groups) increased (p < .05) plasma cortisol compared to the other groups. It can be concluded that the addition of Rosmarinus officinalis and/or Artemisia herba alba in ram diet can have a positive effect on the reproductive function by increasing the concentration and motility of sperm, plasma testosterone, and sexual behavior.

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Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L.

Cited by 161 publications

References 42 publications

Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Anticancer Potential of β‐Carboline Alkaloids: An Updated Mechanistic Overview

Incorporation of fresh leaves of wormwood (Artemisia herba alba) and/or rosemary (Rosmarinus officinalis) in the diet of rams: Effect on testicular function, sexual behavior, and blood parameters

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