Genotoxic and cytotoxic effects of<i>Artemisia herba-alba</i>on mammalian cells

Abderrahman, Salim M.; Shbailat, Seba Jamal

doi:10.1080/0144235x.2014.974355

Cited by 11 publications

(3 citation statements)

References 44 publications

(54 reference statements)

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“…Our results showed that 5 out of 21 plants used by the Moroccan population for treating or preventing COVID-19 were listed to be toxic (Table 5). Concerning the toxicity of Artemisia herba-alba, a study by Abderrahman and Shbailat showed harmful effects on the division of bone marrow cells and the induction of chromatid exchanges at doses of 375 and 500 μg ml − 1 [30], while another study mentioned the potential renal toxicity of this plant [31]. N. oleander is known for its toxicity due to the presence of cardiac glycosides in all plant parts.…”

Section: Toxic Plantsmentioning

confidence: 99%

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Chebaibi

Bousta

Bourhia

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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During the COVID-19 pandemic, the Moroccan population, like the entire population of the world, used medicinal plants to treat or cure symptoms of SARS-CoV-2. The present work was designed to identify the medicinal plants used by the Moroccan population in the prevention or treatment of COVID-19. To achieve this goal, a survey was conducted to collect data on plants along with the sociodemographic parameters of users. The outcome of this work showed that 1,263 people were interviewed with 63.5% male, aged between 18 and 82 years. Most plant users were between 20 and 40 years, which constituted 80.1% of the study population. The level of education of participants was 70.9% university and 27.6% secondary. The most useful plants were eucalyptus, cloves, lemon, and garlic. Notably, 61.9% of interviewed people used plants for preventing or treating COVID-19: 30.6% of them declared one-time use from the beginning of the pandemic, and 47.8% declared frequent daily use until recovery, while 17.4% declared single daily use. Five out of twenty-one plants used in the treatment are known for their potential toxicity, including Artemisia herba-alba and oleander ( Nerium oleander ). The findings of the present work could serve society by providing potential medicinal plants to control COVID-19.

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Section: Toxic Plantsmentioning

confidence: 99%

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Chebaibi

Bousta

Bourhia

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Despite the promising therapeutic potential of the cited species, informants were fully aware of the possible consequences of overuse and drug interactions, particularly in the case P. harmala and A. herba alba . This belief is supported by convincing arguments regarding the safety of both species as they have been reported to cause side effects in animal and human case reports [70,71,72]. Importantly, some of the side effects may also be due to herb–drug interactions, especially, that the concurrent use of both traditional and pharmaceutical medications for treating hypertension or other chronic diseases is a worldwide tendency [73].…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial

et al. 2019

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Hypertension is highly prevalent among the Lebanese adult population and is indeed the major cause of mortality in Lebanon. Traditional use of antihypertensive medicinal plants has long been practiced. The aim of this study is to document this traditional knowledge and clinically test the antihypertensive capacity of three of the most commonly used wild plant species Mentha longifolia, Viola odorata and Urtica dioica. Ethno-pharmacological data was collected by personal interviews with herbalists and traditional healers using a semi structured survey questionnaire and assessing relative frequency of citation (RFC). The clinical study was conducted by a randomized, blind, placebo-controlled trial in 29 subjects with mild hypertension distributed in four groups, three plant extract treatments and one placebo. Systolic (SBP) and diastolic blood pressures (DBP) as well as mean arterial blood pressures (MAP) were monitored at weeks 4, 8, 12 and 16 during the treatment with 300 mL/day of plant extract. Results showed that M. longifolia, U. dioica and V. odorata exhibited the highest values of RCF (0.95) followed by Allium ampeloprasum (0.94), Apium graveolens (0.92) and Crataegus azarolus (0.90). The clinical trial revealed dose- and duration-dependent significant reductions in SBP, DBP and MAP of subjects treated with M. longifolia, U. dioica or V. odorata. Our findings indicate that extracts of these plants present an effective, safe and promising potential as a phyto-therapuetical approach for the treatment of mild hypertension. More research on the phytochemistry, pharmacological effects and the underlying mechanisms is necessary.

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“…BrdU tablets were compressed using pellet press (Parr Instrument Company, Moline, ILLinois, USA) equipped with punch of 0.178” diameter as described by Allen et al[ 17 18 ] Portions of 200 mg mounting powder were mixed with the BrdU dye, and firmly pressed to maintain consistent compaction, hence dissolution rate among tablets. Tablets were kept in a freezer until used.…”

Section: Methodsmentioning

confidence: 99%

In vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L.

et al. 2018

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OBJECTIVE:Silymarin, extracted from the seeds of Silybum marianum L. (Milk thistle), is traditionally used for treating various illnesses such as diabetes, cancer, inflammation, hepatitis, liver cirrhosis, and renal problems. Acute cytotoxicity and genotoxicity studies have been reported with ambiguous outcomes; however, its relevant anticlastogenic potential is not yet evaluated. This study was aimed to evaluate in vivo subacute anticlastogenic properties of silymarin to validate its use as a medicinal agent.MATERIALS AND METHODS:Silymarin was isolated from seeds of milk thistle. Various genotoxicity bioassays of silymarin were performed using mice. First, the bone marrow cell proliferation was estimated by calculating mitotic index. Second, the chromosomal abnormalities in mice bone marrow cells were studied. Third, micronucleated polychromatic erythrocytes (MPE) test and in vivo activation of sister chromatid exchanges (SCEs) were carried out in mice bone marrow cells. Finally, primary spermatocytes were analyzed to estimate genotoxic effect of silymarin on germ cells.RESULTS:We found that silymarin is capable of inducing a significant increase (P ≤ 0.05) in cell proliferation of bone marrow cells. There is no increase in chromosomal aberrations following silymarin treatments. Results clearly showed that it significantly (P ≤ 0.05) decreased the MPE. Likewise, it was found to be a negative inducer of SCEs. It decreased in total abnormal metaphase, SCEs, MPE, and aberrant diakinesis.CONCLUSION:The results demonstrated that silymarin has a strong anticlastogenic activity upon mice genome in somatic and germ cells, indicating its safe use as a medicinal substance. Furthermore, it is not only safe but also has protective effect from clastogens.

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Genotoxic and cytotoxic effects ofArtemisia herba-albaon mammalian cells

Cited by 11 publications

References 44 publications

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial

In vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L.

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