Composition and aggregational forms of biliary lipids in human bile after short-term administration of Taurohyodeoxycholic acid

Effect of Chronic Administration of Tauro-hyodeoxycholic Acid on Biliary Bile Acid Composition and on Biliary Lipid Secretion in Humans

“…Our results obtained during chronic administration do not con rm those obtained during acute administration of T-HDCA to patients with interrupted enterohepatic circulation (19,20) showing 20%-70% enrichment of the pool with T-HDCA and enhanced biliary phospholipid secretion. The reasons for this discrepancy are unclear.…”

“…This explanation is purely speculative, because we did not measure fecal bile acid excretion, but it is supported by the observation that enrichment of the pool with T-HDCA has been reported to be higher (enrichment range between 35% and 70%) in experimental conditions of complete than in conditions of partial depletion of endogenous bile acid pool (enrichment range between 27% and 30%) as achieved by complete (20) or partial (19) interruption of the enterohepatic circulation, respectively. Median enrichment was even lower at 7% in our study under the condition of intact enterohepatic circulation, indirectly suggesting that T-HDCA may be progressively less bioavailable when a physiological load of endogenous bile acids competes for intestinal absorption.…”