Effect of Chronic Administration of Tauro-hyodeoxycholic Acid on Biliary Bile Acid Composition and on Biliary Lipid Secretion in Humans

Abstract

By contrast with acute administration in patients with interrupted enterohepatic circulation, chronic administration of tauro-hyodeoxycholic to man with intact enterohepatic circulation has little effect on biliary lipid composition and secretion.

Relative in Vitro Efficacy of the Phosphate Binders Lanthanum Carbonate and Sevelamer Hydrochloride

“…Chemically, bile acids are carboxylic acids with a cyclopentanoperhydrophenanthrene nucleus and a branched side chain of 3–9 carbon atoms. There are few references to the actual concentration of bile acids in the duodenum, and therefore, reported concentrations in bile were used 27–30…”

“…The bile acid mixture was chosen to be representative of that reported to be present in human bile (total concentration 30 mM), and comprised: glycocholic acid (9 mM), glycochenodeoxycholic acid (9 mM), glycodeoxycholic acid (4.5 mM), taurocholic acid (3 mM), taurochenodeoxycholic acid (3 mM), and taurodeoxycholic acid (1.5 mM) 27–30. Lower bile acid concentrations were prepared by dilution of the stock mixture.…”