Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Rotrekl, Dominik; Šalamúnová, Petra; Paráková, Lenka; Baďo, Ondrej; Saloň, Ivan; Štěpánek, František; Hanuš, Jaroslav; Hošek, Jan

doi:10.1016/j.carbpol.2020.117142

Cited by 24 publications

(14 citation statements)

References 43 publications

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“…The occurrence and development of UC are mostly related to the imbalance of inflammatory factors secreted by immune cells. TNF-α, IL-1β, and IL-6 were proinflammatory factors, IL-10 was an anti-inflammatory factor, and the regulatory effect of drugs on them reflects their anti-inflammatory effect to a certain extent . We compared the regulatory effects of two kinds of NPs on proinflammatory (TNF-α, IL-1β, and IL-6) and anti-inflammatory (IL-10) factors in LPS-activated NCM 460 and raw 264.7 cells.…”

Section: Resultsmentioning

confidence: 99%

“…TNF-α, IL-1β, and IL-6 were proinflammatory factors, IL-10 was an anti-inflammatory factor, and the regulatory effect of drugs on them reflects their anti-inflammatory effect to a certain extent. 43 We compared the regulatory effects of two kinds of NPs on proinflammatory (TNF-α, IL-1β, and IL-6) and anti-inflammatory (IL-10) factors in LPS-activated NCM 460 and raw 264.7 cells. As shown in Figure 3C,D, Mag@CS-Zein NPs and Mag@CUL-Zein NPs both significantly reduced the levels of TNF-a, IL-6, and IL-1β and increased the level of IL-10 in NCM 460 and raw 264.7 cells.…”

Section: Effects Of Mag@cs-zein Nps On Inflammatorymentioning

confidence: 99%

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Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Wang

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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Although magnolol (Mag), an anti-inflammatory natural compound, has been demonstrated to play protective effects on ulcerative colitis (UC), its application as an alternative therapeutic reagent for UC treatment is still greatly impeded due to its poor stability in the gastrointestinal tract and insufficient accumulation in the inflamed colon lesion. Nano-/microsized drug delivery systems can potentially overcome some challenges regarding the oral administration of phytochemicals, which still confront premature early drug release, degradation of NPs, or the sustained drug release of MPs. In this study, we primarily loaded Mag into the core–shell zein-based nanoparticles with chondroitin sulfate coating (Mag@CS-Zein NPs) with an average size of 142.27 ± 5.11 nm, showing significant macrophage-targeting and enhanced colon epithelial cellular uptake capacity. Then, we embedded Mag@CS-Zein NPs into hydrogel microspheres via an electrospraying technology. The Mag@CS-Zein NPsinMPs presented a uniform-sized sphere with an average size of 164.36 ± 6.29 μm and sustained drug-release profiles. Compared to CS-Zein NPs, the developed CS-Zein NPsinMPs exhibited prolonged colon retention on the inflammatory surface, as seen from ex vivo and in vivo imaging fluorescence adhesion experiments. Based on the advantage of the combination of hybrid nanoparticles-in-microparticles, oral administration of Mag@CS-Zein NPsinMPs significantly alleviated colitis symptoms in DSS-treated mice by regulating the expression levels of proinflammatory cytokines (TNF-α, IL-6, and IL-1β) and anti-inflammatory cytokines (IL-10) and factor accelerated colonic mucosal barrier repair via upregulating the expression of ZO-1 and occludin. This study provides great insights into the oral drug delivery of natural compounds for UC therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Effects Of Mag@cs-zein Nps On Inflammatorymentioning

confidence: 99%

Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Wang

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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“…Curcumin with glucan particles efficiently reduced the TNFα, IL-1β, and IL-6 activity as compared to the physical mixture of native curcumin and glucan particles in DSS-induced colitis in rats. It can also be able to decrease the activity of MMP-9 [122]. See the details of in vitro and animal studies of curcumin combinations with other therapeutic molecules and administration of modified curcumin formulations for IBD treatment in Table 4.…”

Section: Curcumin Combinations With Other Therapeutic Molecules and Modified Curcumin Formulations In Inflammatory Bowel Diseasementioning

confidence: 99%

Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

et al. 2021

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Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disorder of the small intestine and colon. IBD includes ulcerative colitis (UC) and Crohn’s disease (CD), and it is a major factor for the development of colon cancer, referred to as colitis-associated cancer (CAC). The current treatment of IBD mainly includes the use of synthetic drugs and monoclonal antibodies. However, these drugs have side effects over long-term use, and the high relapse rate restricts their application. In the recent past, many studies had witnessed a surge in applying plant-derived products to manage various diseases, including IBD. Curcumin is a bioactive component derived from a rhizome of turmeric (Curcuma longa). Numerous in vitro and in vivo studies show that curcumin may interact with many cellular targets (NF-κB, JAKs/STATs, MAPKs, TNF-γ, IL-6, PPARγ, and TRPV1) and effectively reduce the progression of IBD with promising results. Thus, curcumin is a potential therapeutic agent for patients with IBD once it significantly decreases clinical relapse in patients with quiescent IBD. This review aims to summarize recent advances and provide a comprehensive picture of curcumin’s effectiveness in IBD and offer our view on future research on curcumin in IBD treatment.

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“…Compared with other YPs-based oral administration drug delivery systems, ,, there are four key advantages, which include, first, all materials used in this study are natural and nontoxic, such as OVA, HA, and YPs. Though PEI was introduced to reverse the surface charge and surprisingly improved EE of NPs, the dosage was too low to cause toxicity .…”

Section: Discussionmentioning

confidence: 99%

Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment

et al. 2021

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In this study, we developed an advanced colitis-targeted nanoparticles (NPs)-into-yeast cell wall microparticles (YPs) drug delivery system for ulcerative colitis (UC) therapy. In brief, YPs entrap hyaluronic acid (HA), and polyethylenimine (PEI) modified rhein (RH)-loaded ovalbumin NPs (HA/PEI-RH NPs) to form HA/PEI-RH NYPs. YPs can make HA/PEI-RH NPs pass through gastric environment stably and be degraded by β-glucanase to promote drug release from HA/PEI-RH NYPs in the colon. Cellular uptake evaluation confirmed that HA/PEI-RH NPs could specifically target and enhance the uptake rate via HA ligands. In biodistribution studies, HA/PEI-RH NYPs were able to efficiently accumulate in the inflammed colon in mice. In vivo experiments revealed that the HA/PEI-RH NYPs could significantly alleviate inflammation by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Therefore, HA/PEI-RH NYPs have advantages of good gastric stability, β-glucanase-sensitive release ability, macrophagetargeted ability, and anti-UC effects. These advantages indicate YPs-entrapped multifunctional NPs are a promising oral drug delivery system for UC therapy.

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Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Cited by 24 publications

References 43 publications

Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment

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